Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition • 09-14 May 2026

Oral

Take a Breath: Chest, Thoracic, and Pulmonary MRI

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Take a Breath: Chest, Thoracic, and Pulmonary MRI
Oral
Body
Monday, 11 May 2026
Hall 1B
08:20 - 10:10
Moderators: Laura Saunders
Session Number: 302-02
No CME/CE Credit
This oral session includes presentations that utilize pulmonary functional MR imaging and thoracic oncologic MR imaging.
Skill Level: Intermediate

08:20 Figure 302-02-001.  Functional lung MRI during tachypnea detects changes in regional ventilation after dual bronchodilator treatment in COPD
Summa Cum Laude AMPC Selected
Robin Müller, Andreas Voskrebenzev, Filip Klimeš, Marius Klein, Frank Wacker, Jens Vogel-Claussen, Jens Hohlfeld
Hannover Medical School, Hannover, Germany
Impact: Metronome-paced tachypnea is a feasible alternative to exercise testing and demonstrates greater sensitivity to single-dose dual bronchodilator effects in COPD patients when assessed using single-slice functional lung MRI.
08:31 Figure 302-02-002.  Phase-resolved functional lung (PREFUL) versus arterial spin labeling (ASL) MRI for noninvasive measurement of lung perfusion
Petros Martirosian, Andreas Voskrebenzev, Filip Klimeš, Rolf Pohmann, Thomas Küstner, Martin Schwartz, Fritz Schick, Jens Vogel-Claussen, Cecilia Liang
University Hospital of Tuebingen, Tuebingen, Germany
Impact: This study compares two noninvasive techniques for quantitative assessment of lung perfusion. The PCASL technique yields higher perfusion values than those measured with PREFUL. Further efforts are needed to better understand the reasons for the differences between the two methods.
08:42 Figure 302-02-003.  Categorical 1H VOLVE Lung MRI Quantifies Ventilation Magnitude and Delay in Cystic Fibrosis and CFTR Modulator Response
Zachary Peggs, Jonathan Brooke, Christabella Ng, Alexander Yule, Andrew Prayle, Helen Barr, Charlotte Bolton, Alan Smyth, Ian Hall, Penny Gowland, Susan Francis
University of Nottingham, Nottingham, United Kingdom
Impact: VOLVE analysis provides quantitative assessment of regional ventilation amplitude and delay in people with CF. Categorical metrics highlight clinically relevant differences and therapy-related changes not reflected by spirometry, supporting the use of MRI in longitudinal evaluation of regional lung function.
08:53 Figure 302-02-004.  Pulmonary ventilation mapping using a non-commercial very-low field MRI system
Nicholas Senn, Gabriel Zihlmann, Lucie Moreau, Alexiane Pasquier, Xavier Maître, Mathieu Sarracanie, Najat Salameh
University of Aberdeen, Aberdeen, United Kingdom
Impact: We demonstrate the feasibility of 3D-lung ventilation mapping across the pulmonary respiratory cycle using an approach tailored to hardware constraints typical of emerging very-low field MRI systems. Once validated, such mapping methods could support future diagnosis in communities and children.
09:04 Figure 302-02-005.  An ALP-MRI Score for Assessing Combined Structural and Functional Lung Performance in Neonatal Bronchopulmonary Dysplasia
Jonathan Dyke, Lauren Blatt, Andreas Voskrebenzev, Filip Klimeš, Jens Vogel-Claussen, Stefan Worgall, Mert Sabuncu, Rachit Saluja, Arindam RoyChoudhury, Alan Wu, Jeffrey Perlman, Arzu Kovanlikaya
Weill Cornell Medicine, New York, United States of America
Impact: The ALP-MRI score combines structural and functional lung metrics into a single score which differentiates between BPD Grades 1 and 2/3. The score identifies abnormalities in each of the three main lung compartments of airways, lung parenchyma and pulmonary vasculature.
09:15 Figure 302-02-006.  RadiolGAN: A Multicenter Study of Synthetic CT from 3D UTE MRI to Enhance Pulmonary Radiologic Sign Visualization
xiaoqing Wu, Xi Zhu, Jie Shi, Chaoyin Tang, Yanbin Cui, Jing Ye, Wennuo Huang, Wei Xia
Dalian Medical University, Dalian, China
Impact: RadiolGAN enables high-fidelity UTE-to-CT image translation, enhancing the depiction of radiologic features and structural details across diverse lung conditions. This approach highlights the potential role of GAN-based synthesis in supporting future clinical applications of lung MRI.
09:26 Figure 302-02-007.  A Novel Independent Component Analysis Method for Non-Contrast-Enhanced Pulmonary Ventilation and Perfusion MRI
Laura Rozo Pardo, Rabea Klaar, Moritz Rabe, Christopher Kurz, Enrico Schulz, Bastian Sabel, Olaf Dietrich
LMU Klinikum Munich, München, Germany
Impact: We introduce a new robust free-breathing technique for non-contrast-enhanced functional lung imaging based on independent component analysis, evaluated on 0.35 T MR-Linac. It improves key limitations of standard methods, like sensitivity to irregular breathing and motion artifacts.
09:37 Figure 302-02-008.  Phase-resolved functional lung and 19F MRI detect early treatment response to mepolizumab in patients with severe asthma
Magna Cum Laude
Julienne Scheller, Hendrik Suhling, Arnd Obert, Marius Klein, Nora Drick, Marcel Gutberlet, Andreas Voskrebenzev, Peter Howarth, Frank Wacker, Jens Vogel-Claussen
German Center for Lung Research (DZL), Munich, Germany
Impact: PREFUL and 19F MRI enable early, non-invasive assessment of anti-interleukin-5 biologic treatment response in severe asthma. These functional imaging techniques outperform global spirometry, offering sensitive regional markers for monitoring biologic therapy effects and guiding personalized asthma management.
09:48 Figure 302-02-009.  Real-Time Tracking of Tumor-Associated Macrophages In Vivo Using Hyperpolarized 129Xe MRI
Yuqi Yang, Sen Yue, Huiling Dong, Ming Zhang, Xiuchao Zhao, Xin Zhou, Chuan Qin
State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China
Impact: This study establishes a novel, non-invasive and radiation-free molecular imaging strategy for early lung cancer detection in living subjects.
09:59 Figure 302-02-010.  Simplifying Hyperpolarized Xenon Pulmonary Gas-Exchange MRI
Seth Lee, Suphachart Leewiwatwong, Anna Costelle, David Mummy, Bastiaan Driehuys, John Mugler
Duke University, Durham, United States of America
Impact: Initial calibrations to determine TE90 for dissolved-phase Dixon decomposition require additional hyperpolarized 129Xe doses that drive up cost and complexity. We developed a method to correct images acquired at arbitrary TE, thus obviating the need for initial calibration scans.

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