Muscle Microstructure and Deformation
Digital Poster
Musculoskeletal
Monday, 11 May 2026
Diffusion Tensor Imaging (DTI), elastography and PC-MRI in muscle
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367-03-001.
Characterisation of skeletal muscle changes in rheumatoid arthritis using novel multi-parametric MRI
Impact: With quantitative MRI, we expect to demonstrate
changes in muscle structure and composition in patients with rheumatoid arthritis
as compared to controls. This will ultimately permit stratification of patients
for future exercise, dietary, and pharmacological intervention trials.
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367-03-002.
Leveraging Diffusion MRI to Detect Heterogeneous Fiber Remodeling in Simulated Skeletal Muscle
Impact: This study investigated the relationships between mean and the distribution of skeletal muscle fiber sizes across diverse injury models, identifying relationships diffusion magnetic resonance imaging metrics and underlying skeletal muscle microstructure using three different diffusion encoding strategies
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367-03-003.
Estimation of Muscle Cell Diameter with the RPBM: Correlation with Subject Characteristics and Isometric Torque
Impact: RPBM enables robust estimation of muscle
microstructure from time-dependent diffusion MRI. In healthy subjects, cell
diameter depends on age, weight, sex, and muscle group but not on muscle
strength, highlighting the importance of sex-adjusted models in quantitative
muscle MRI.
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367-03-004.
Noninvasive assessment of human skeletal muscle fiber type after biopsy using diffusion tensor imaging and Q-space imaging
Impact: Q-space imaging (QSI) provides a noninvasive and accurate method to evaluate skeletal muscle microstructure and fiber-type composition, offering a promising alternative to muscle biopsy and improving the understanding of muscle microstructure beyond conventional diffusion tensor imaging.
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367-03-005.
Anisotropic MR Elastography of Lumbar Spinal Muscle
Impact: Noninvasively assessing lumbar spine mechanics using this novel anisotropic
MR elastography approach will help serve as an early predictor of a patient’s
vulnerability to nonspecific mechanical low back pain, ultimately contributing
toward improved diagnostic measures and more targeted treatment options.
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367-03-006.
Multiparametric MRI for Skeletal Muscle Health Assessment in High-Technology Gait Rehabilitation
Impact: Multiparametric MRI enables objective, non-invasive
assessment of skeletal muscle recovery in robotic-assisted rehabilitation.
Baseline morphological biomarkers may predict functional improvement,
supporting MRI’s role as a quantitative tool for personalized therapy
monitoring and outcome prediction in neuromuscular rehabilitation.
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367-03-007.
Estimation of muscle fiber diameter using time-dependent diffusion MRI in masticatory myofascial pain syndrome
Impact: Time-dependent
diffusion MRI with RPBM modeling offers a non-invasive approach to quantify
muscle fiber diameter and detect microstructural alterations in the masseter
and temporalis muscles associated with masticatory myofascial pain syndrome,
potentially enabling objective biomarkers for this prevalent disorder.
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367-03-008.
Muscle Diffusion Tensor Imaging In Late-Onset Pompe Disease
Impact: Muscle diffusion tensor imaging metrics are evaluated as potential biomarkers of early muscle involvement in late-onset Pompe disease, particularly in muscles that have not yet been affected by significant fat replacement.
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367-03-009.
Qualitative comparison of voluntary and electrically evoked forearm muscle contractions with 3D dynamic phase-contrast MRI
Impact: Voluntary and NMES-evoked contractions differ fundamentally in motor-unit and fibre-type recruitment. Here, we demonstrate that phase-contrast MRI can discriminate their distinct spatiotemporal strain patterns, providing a non-invasive framework to refine NMES protocols and interpret muscle activation.
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367-03-010.
Carnosine content and mitochondrial function in the skeletal muscle: heteronuclear 1H/31P MR spectroscopy in humans
Impact: This study demonstrates that gastrocnemius carnosine concentration predicts ATP cost of contraction and initial H⁺ efflux, providing a functional biomarker for skeletal muscle energetics and performance, independent of oxidative or glycolytic capacity, enabling targeted assessment of muscle function.
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367-03-011.
Multi-b-value MAP-MRI of Skeletal Muscle Microstructure and Exercise Effects
Impact: MAP-MRI metrics may serve as sensitive imaging biomarkers for detecting exercise-induced microstructural and physiological changes in skeletal muscle, providing a more detailed understanding of muscle function beyond conventional diffusion tensor analysis.
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367-03-012.
Studying functional and pathological effects on dynamic phase-contrast MRI measurements in muscles: A simulation framework
Impact: A Bloch-simulation model for phase-contrast MRI of contracting skeletal muscle enables studying factors that influence the measurements separately, such as pathophysiological tissue changes. It supports optimization of imaging protocols for neuromuscular diseases and helps the interpretation of in vivo results.
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367-03-013.
Spatiotemporal relationship between hamstring muscle activation and strain rate during dynamic knee flexion
Impact: This work combines VE-PC MRI and multi-channel EMG to study spatial neuromechanical
coupling in vivo, enabling quantitative assessment of activation–strain rate
relationships. The approach may advance MRI-based muscle physiology and inform
future investigations of spatially heterogeneous contraction dynamics.
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367-03-014.
Longitudinal assessment of skeletal muscle membrane permeability in Becker muscular dystrophy via 31P-MRS and DT-MRI
Impact: We demonstrate metrics of muscle membrane
permeability as early markers of disease in Becker muscular dystrophy. These
will allow the assessment of treatment effects in healthy-appearing muscles, rather
than fat-replaced muscles, helping to preserve muscle tissue in this
progressive disorder.
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367-03-015.
Assessing Muscle Perfusion and Microstructure in Aging with Flow-Compensated IVIM MRI
Impact: Perfusion parameters derived using Intravoxel Incoherent Motion (IVIM) MRI in skeletal muscle may be associated with microstructural alterations and muscle fiber atrophy. Furthermore, these parameters could help differentiate healthy from sarcopenic older adults.
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