Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Non-Proton MRI: Methods and Applications

Non-Proton MRI: Methods and Applications

Digital Poster

Contrast Mechanisms

Tuesday, 12 May 2026

Digital Posters Row J

16:00 - 16:55

Session Number: 469-05

No CME/CE Credit

Similar Sessions

This session presents emerging clinical and preclinical applications of non-proton MRI.

		469-05-001. Impact of Skin Barrier Function on Skin Sodium Quantification with 23Na MRI at 7T Aditya Jhajharia, Jie Zhu, Zanib Naeem, Katrina Abuabara, Michael Ohliger, An Vu, Jeremy Gordon University Of California, San Francisco (UCSF), United States of America Impact: This study establishes the repeatability and reliability of sodium (²³Na) MRI for skin sodium quantification and demonstrates its capability to detect changes associated with skin barrier function, providing a foundation for non-invasive assessment of disease-related alterations.
		469-05-002. Open-source implementation and validation of the 3D CRISTINA sodium MQC sequence Valentin Jost, Dominik Zehender, Frank Zoellner Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany Impact: Releasing a Pulseq-based 3D-CRISTINA sodium multi-coherence imaging implementation enables reliable simultaneous single and triple quantum imaging across various scanner platforms, supporting cross-site validation and technological innovation in sodium MRI, thereby accelerating development of quantitative biomarkers of cellular viability.
		469-05-003. Variability in 13C MRS measurement of Leg Glycogen in Children. Abi Spicer, Elizabeth Simpson, Ian Macdonald, Penny Gowland, Stephen Bawden University of Nottingham, Nottingham, United Kingdom Impact: With both intra-subject and inter-subject reproducibility of leg skeletal muscle glycogen (LMGly) measures in children matching literature values for adults, this shows the viability of MRS as a tool to measure LMGly in a diverse populations.
		469-05-004. Sub-Millimolar in vivo 1H/19F MRI Boosted by a Metamaterial Enhancer and Advanced Denoising Teng Gong, Anfeng Li, Shuangchen Li, Lele Ma, Pingsheng Huang, Zhong-Xing Jiang, Xiaolei Song Tsinghua University, Beijing, China Impact: We enabled sub-millimolar in vivo ¹⁹F-MRI of a fluorinated nanoprobe, by integrating metamaterial enhancers, sequence optimization and BM3D denoising. The significant improvement of sensitivity (>5 folds) could facilitate the application of ¹⁹F-MRI cell tracking and cancer therapy monitoring.
		469-05-005. Reproducibility Analysis of brain and calf muscle energy metabolism using 31P MRS at 3.0T Mengyuan Xu, Jin Cai, Baiyan Jiang, Yinghui Ge, Zhiping Guo Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, China Impact: This study demonstrates high test-retest repeatability of ³¹P-MRS for quantifying phosphate metabolism in the brain and calf muscle at 3T, supporting its use in longitudinal clinical studies for monitoring disease progression and treatment response.
		469-05-006. Reference-Free Intensity Correction for 7T ²³Na MRI: A Comparative Study Yuancheng Jiang, Jianxun Qu, Armin NAGEL, Caohui Duan MR Research Collaboration, Siemens Healthineers Ltd., Beijing, China Impact: This work provides a guideline for selecting an optimal reference-free intensity correction method for 7T ²³Na MRI. By enabling accurate quantification without extra scan time, our findings can accelerate the clinical translation of quantitative ²³Na MRI in neurological disorders.
		469-05-007. ¹³C-lactate imaging without hyperpolarization using Selective Polarization Transfer (SPT) / NOE CSI-SSFP experiments Elton Montrazi, Lucio Frydman Weizmann Institute, Rehovot, Israel Impact: Our results demonstrate that ¹³C-lactate can be detected in tumors by tracking injected ¹³C-glucose, without hyperpolarization, using SPT/NOE-CSI-SSFP experiments that enhance the SNR by a factor of 2–3 compared with conventional SSFP.
		469-05-008. 7T 31P MT-ISIS for Quantifying CK and ATPase in Human Skeletal Muscle Ying-Hua Chu, Caixia Fu, Wenwen Yu, He Wang, Yi-Cheng Hsu MR Research Collaboration Team, Shanghai, China Impact: A 7T ³¹P magnetization transfer (MT-ISIS) protocol quantifies PCr↔ATP (CK) and Pi→ATP (ATPase) in ~5 minutes, yielding T₁ and exchange rates consistent with prior literature and robust to flip angle errors.
		469-05-009. Subject-Specific Voxel Model for Assessing the Impact of B1- Correction on aTSC in Quantitative 23Na MRI at 7T Jana Losch, Thomas Fiedler, Anna Scheipers, Armin NAGEL, Mark Ladd, Tanja Platt German Cancer Research Center (DKFZ), Heidelberg, Germany Impact: When simulating B₁^- for inhomogeneity corrections in quantitative ²³Na MRI, generic voxel models may suffice for reliable organ-specific aTSC estimation. This is encouraging, as using readily available models avoids complex personalized modelling, thus supporting wider adoption of quantitative sodium MRI.
		469-05-010. Multicolor 19F MRI using Spectral Hadamard-Encoding Kian Tadjalli Mehr, Felix Spreter, Simon Reiss, Johannes Fischer, Ali Özen, Natalie Hoppe, Gunjan Arya, Alexander Maier, Michael Bock University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany Impact: For Multicolor ¹⁹F MRI Hadamard-encoding is a simple alternative to selective refocusing or deconvolution methods, which can efficiently differentiate an arbitrary number of resonances, making it a powerful tool in combination with spectral fitting.
		469-05-011. A Homogeneous Perfluorocarbon Phantom for Quantitative 19F MRI of Large Animals Kian Tadjalli Mehr, Ali Özen, Felix Spreter, David Boll, Simon Reiss, Lisa Regler, Johannes Fischer, Alexander Maier, Michael Bock University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany Impact: The affordable, homogeneous ¹⁹F phantom enables accurate sensitivity mapping of ¹⁹F coils, supporting coil development and quality assurance of the imaging hardware.
		469-05-012. Open-source Bloch–Siegert and Double Flip Angle B₁ mapping for sodium MRI with optional TV-accelerated reconstruction Valentin Jost, Dominik Zehender, Safa Özdemir, Frank Zoellner Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany Impact: We propose two Pulseq sequences with high undersampling for sodium B₁ mapping. Implemented within an open source framework, they allow for reproducible and compatible results, therefore, facilitating broader access to quantitative sodium MRI.
		469-05-013. Orientation Dependence of the 1H Solid-State NMR Spectrum and T1Ds at the Myelin/Water Interface Cariad Knight, Alex Ensworth, Cornelia Laule, Alex MacKay, Carl Michal University of British Columbia, Vancouver, Canada Impact: Directly probes the myelin membrane-water interface, resolving orientation-specific 1H features that link solid-state NMR approaches to T_1D/ihMT mechanisms. Understanding myelin membrane organization and dynamics can improve design and interpretation of myelin-sensitive MRI and strengthen validation of demyelination biomarkers in vivo.
		469-05-014. In vivo high-resolution phosphorus metabolite mapping using a novel multi-resolution approach for 31P MRSI at 7 Tesla Jan-Philipp Schmitz, Justyna Platek, Bela Seng, Peter Bachert, Mark Ladd, Andreas Korzowski, Vanessa Franke German Cancer Research Center (DKFZ), Heidelberg, Germany Impact: To advance the research and clinical applicability of ³¹P MRSI, we demonstrate the utility of multi-resolution quantification in vivo. We validate its ability to improve quantification robustness for low-SNR metabolites and enable reliable extracellular pH mapping in accelerated acquisitions.
		469-05-015. Modelling Stimulated Echoes in Single Shot Fixed Sodium Reconstruction for TQ/SQ correction Dominik Zehender, Valentin Jost, Lothar Schad, Frank Zoellner Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany Impact: Using a Lorentzian model for the fixed TQTPPI wo180 reconstruction we are able to extract $T^*_{2s/f}$ despite stimulated echoes. This will potentially enable the correction of the sodium TQ-signal to the optimal evolution time when not measured at $t_{evo}=t_{opt}$.
		469-05-016. A Birdcage Any-nucleus Distributed Active Programmable Transmit (ADAPT) Coil Jóan Hofgaard Køtlum, Michiel Esvelt, Ingmar Voogt, Busra Kahraman, Mark Gosselink, Vitaliy Zhurbenko, Dennis Klomp, Jan Ardenkjaer-Larsen, Victor Han Technical University of Denmark, Kgs. Lyngby, Denmark Impact: We present a pathway towards an any-nucleus transmit coil that could replace traditional MRI body coils. This would enable routine X-nuclei imaging and spectroscopy by simply changing receive coils for different nuclei, providing information for early diagnosis and treatment evaluation.