Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition • 09-14 May 2026
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470-11-157.
Bile acids detection by 1H-MRS in patients with various cholesterol levels
Impact: This study demonstrates
the feasibility of STEAM ¹H‑MRS for noninvasive bile composition
assessment, revealing spectral differences in subjects with various levels of hypercholesterolemia.
The findings support its potential clinical utility for monitoring cholesterol‑related
alterations in bile metabolism.
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470-11-158.
Non-Invasive Prediction of IDH Mutation in Gliomas Using MEGA-PRESS and an Attention Deep Shallow Network (ADSN)
Impact: An Attention Deep Shallow Network (ADSN) accurately identified IDH mutational status from MEGA-PRESS data (F1-scores of 0.884 (validation) and 0.835 (test)). IDH-mutant gliomas had significantly lower Glu/tCr, Gln/tCr, and Glx/tCr ratios when compared with IDH-wildtype gliomas.
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470-11-159.
Time-Resolved Glutamate Dynamics During Working Memory
Impact: We
report distinct glutamate time courses during a working memory task, with
significant increases in memory versus control conditions. This approach may
enable more detailed examination of stimulus-evoked glutamate responses and differences
in glutamate dynamics across patient populations.
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470-11-160.
7T MRSI Biomarkers in Gliomas: Quantitative comparison through Multimodal Correlation with Mass Spectrometry
Impact: MRSI/MS ratio comparisons showed close correspondence for Gln and Cho, moderate variability for Ins, and higher deviations for Gly and NAA. All IDH-mutant gliomas showed 2HG in MS spectra, confirming biochemical specificity and sampling precision with a scope for improvement.
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470-11-161.
Identifying out-of-voxel echoes in edited MRS with phase cycle inversion
Impact: Out-of-voxel artifacts remain a persistent obstacle to accurate metabolite quantification. Identifying their coherence transfer pathway origins is key to developing targeted suppression methods that enhance data quality and confidence in MRS studies.
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470-11-162.
Metabolic Profiling with BrainSpec MRS Reveals Changes after Hematopoietic Stem Cell Transplantation in Pediatric ALD
Impact: BrainSpec provides an efficient and effective framework for quantifying and visualizing metabolic abnormalities in ALD. By converting complex spectral information into interpretable metabolic maps, BrainSpec enhances clinical assessment of treatment response and facilitates longitudinal monitoring of disease progression.
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470-11-163.
Cystathionine T2 Relaxation in Glioma at 3T
Impact: Probing
the T2 of cystathionine to
better understand the intracellular environment of glioma cells.
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470-11-164.
A Dedicated Head RF Coil Array with a Novel Decoupling Method for ²H Metabolic MRS Imaging at Ultrahigh Fields
Impact: The proposed ²H head RF coil with a hybrid
overlap–capacitive decoupling strategy improves imaging coverage and uniformity
at 5 T, offering an efficient tool for ultrahigh-field ²H metabolic MR imaging
and advancing in vivo metabolic studies.
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© 2026 International Society for Magnetic Resonance in Medicine