Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

MR in Organoid/Phantom/Plant/Serum

Digital Poster

Preclinical

Thursday, 14 May 2026

Digital Posters Row F

14:35 - 15:30

Session Number: 665-04

No CME/CE Credit

Similar Sessions

To effectively estimate MR biomarkers for measuring phantoms, organoids, serum, and plants in vitro/in vivo.

		665-04-001. Development of a Dual-Tuned ¹H/²³Na Organoid MRI Platform at 14 Tesla for Hemodynamics-Independent Functional Mapping Grace YU, Martin Thunemann, Ella Zeldich, Shira Klorfeld-Auslender, Xiaochen Liu, David Hike, Chunqi Qian, Anna Devor, Xin Yu, Xiaoqing Zhou Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America Impact: This work establishes the first dual-tuned ¹H/²³Na MRI platform for imaging human cerebral organoids at 14 T, enabling high-resolution structural and ionic mapping. It provides a vascular-free system to directly validate sodium-based neural activity imaging, transforming interpretation of fMRI signals.
		665-04-002. Feasibility of Dynamic 13C-NMR measurements in Patient-Derived Midbrain Organoids to Probe Metabolism in Parkinson’s Disease Marta Pokotylo, Josh Philipp Peters, Farhad Haj Mohamad, Franziska Rudolph, Philip Seibler, Jan-Bernd Hövener, Andrey Pravdivtsev, Jannik Prasuhn University of Luebeck, Luebeck, Germany Impact: This study established the feasibility of combining patient with Parkinson’s disease-derived human midbrain-like organoids with dynamic ¹³C nuclear magnetic resonance spectroscopy for real-time investigation of metabolic fluxes, laying the foundation for biomarker discovery, precision medicine approaches, and disease monitoring methods.
		665-04-003. Integrated MRS-NMR Profiling Reveals Brain-Body Metabolic Disruptions in Buprenorphine-Maintained Opioid Dependent Patients Nisha Chauhan, Anju Dhawan, Biswadip Chatterjee, Siddharth Sarkar, Mani Kalaivani, S Senthil Kumaran All India Institute of Medical Sciences, New Delhi, India Impact: Neurochemical and metabolic alterations persist during buprenorphine maintenance treatment (BMT) in opioid dependence. Brain-serum metabolic imbalance links elevated peripheral muscle catabolism with reduced cortical membrane turnover, highlighting the need for metabolic and nutritional monitoring in neurochemical recovery during addiction care.
		665-04-004. Neurochemistry of SOD1 ALS neurocortical organoids using high-resolution magic angle spinning NMR spectroscopy Alejandra Castilla Bolaños, Colleen Bailey, Vincent Moxley-Paquette, Navroop Dhaliwal, Elena Osipyan, Fermisk Saleh, Andre Simpson, Carol Schuurmans, Jamie Near University of Toronto, Toronto, Canada Impact: We present non-destructive, high-resolution metabolic assessment in ALS-derived neurocortical organoids using HR-MAS NMR spectroscopy. By enabling sensitive detection of neurodegeneration-linked metabolic alterations, this approach provides a potential platform to identify ALS-related metabolic pathways and explore preventive strategies against neurodegeneration.
		665-04-005. Multiscale imaging of human PINK1-mutant brain organoids: linking quantitative MRI and holotomography Nina Luethi, Francisco Fritz, Linn Streubel-Gallasch, Jordi Carstens, Tim Salditt, Thorsten Feiweier, Jannik Prasuhn, Peter Schramm, Norbert Brüggemann, Christine Klein, Philip Seibler, Siawoosh Mohammadi University of Luebeck, Luebeck, Germany Impact: To improve biological interpretation of neurodegeneration MRI markers, we explored organoid-based qMRI for controlled, genotype-specific calibration of diffusion and multiparametric markers, including comparisons against 3D cellular X-ray holotomography.
		665-04-006. Development and Evaluation of a Microcapsule-based Phantom Simulating Intra- and Extracellular Water Diffusion Kazuya Sakoda, Takashi Iwanaga, Hirokazu Otsuka, Masahiko Toyota, Kiyohisa Kamimura, Koji Takumi, Hiroshi Imai, Thorsten Feiweier, Takashi Yoshiura Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima-shi, Japan Impact: We successfully developed a microcapsule-based diffusion phantom that distinctly simulates intra- and extracellular compartments by exhibiting different diffusion coefficients inside and outside the microcapsules, thereby enabling more physiologically relevant modeling of restricted diffusion.
		665-04-007. MRI-Readable Radiation Dosimetry at Low Magnetic Field (64 mT) Kaitlyn Betz, Samuel Oberdick, Stephen Russek, Kathryn Keenan, Eric Johnson, Kalina Jordanova, David Dunkerley, Gregory Penoncello National Institute of Standards and Technology, Boulder, United States of America Impact: Portable low-field magnetic resonance imaging (LF-MRI) at 64 mT can be used for applications in MRI-readable radiation dosimetry, which enables rapid assessment of dose plans using a lower cost MRI system.
		665-04-008. Longitudinal Stability of ASL: A Five-Week Comparison of Human CBF and a Calibrated Perfusion Phantom. Luis Sanmiguel, Soetkin Beun, Liza Vanhauwaert, Pim Pullens, Patricia Clement Ghent University Hospital, Gent, Belgium Impact: This investigation confirms ASL's longitudinal stability in healthy human brain tissue (CoV < 6%). These results validate ASL's reliability for multi-session clinical studies and establish phantom protocols for scanner quality assurance.
		665-04-009. Dynamic Lung MRI of Forced Expiration Using a 3D FLORET Trajectory Sebastian Scheidel, Viktor Hartung, Herbert Köstler, Thorsten Bley, Simon Veldhoen, Tobias Wech University Hospital Würzburg, Würzburg, Germany Impact: This technique enables high-temporal-resolution 3D imaging of forced expiration, to non-invasively asses regional lung deflation dynamics. Unlike spirometry, it provides spatially resolved insight into ventilation and motion patterns, supporting development of novel biomarkers and improving pulmonary function evaluation.
		665-04-010. Design and Validation of 3D-Printed Microstructure Phantoms to Assess Diffusion-Mediated Susceptibility Effects on R2 and R2* Martina Savic, Sebastian Weingärtner TU Delft, Delft, Netherlands Impact: The developed 3D-printed phantoms can provide a controlled platform for investigating how microstructures influence transverse relaxation, supporting the development and validation of microstructure-sensitive MRI methods.
		665-04-011. Is the ISMRM/NIST Phantom Truly Sequence-Independent? Validation and Vulnerability in High-Resolution T2 Mapping. Maryam Abarashi, Thomas Peterson, Clara Fallone, Ali Golestani University of Calgary, Calgary, Canada Impact: Our findings challenge the assumption that NIST/ISMRM phantom values are sequence-independent. Recognizing how fitting choices influence “ground truth” improves transparency in quantitative MRI, motivating the development of open, standardized pipelines for reproducible calibration across scanners, sequences, and research centers.
		665-04-012. Normal and transient Anomalous diffusion to monitor phase transition in polymer solutions Silvia Capuani, Martina Negozio, Alessandra Maiuro, Silvia Franco, Roberta Angelini, Alessandro Taloni, Giulio Costantini National Research Council (CNR), Rome, Italy Impact: Dense liquid to SOL phase transition in polymer solutions that can occurs in extracellular space is detailed monitored by Normal D(t) and transient anomalous diffusion quantified by subdiffusion alpha parameter of OH group
		665-04-013. Functional plant MRI: Propagator-based velocity mapping of flow in vascular bundles in a 9.4-T microimaging system. Sébastien Bär, Noah Knorr, Dominik von Elverfeldt, Jochen Leupold, Linnea Hesse University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany Impact: In-vivo validation of the accelerated flow velocity measurements allows to confidently apply the Pulsed Field Gradient RARE technique to detect flow changes in vascular bundles of plants under mechanical stress, enabling functional plant MRI.
		665-04-014. Evaluation of Fat Profiling Across MRS, Benchtop NMR, and High-field NMR in Oils and Adipose Tissue Using CRAFT Revanth Guntumadugu, Nicole Williamson, Krish Krishnamurthy, Dan Iverson, Aaryani Tipirneni-Sajja University of Houston, Houston, United States of America Impact: This study establishes a unified framework for lipid profiling that bridges analytical NMR and clinical MRS. The approach enhances the fidelity of fat quantification, hence facilitating clinical translation of lipid biomarkers for assessment of metabolic diseases.
		665-04-015. NMR Based Metabolomics Analysis of Metabolic Dysregulation in Pancreatitis – Induced ARDS: A Step Towards Precision Medicine Neeraj Sinha, Deeksha Marwari, Anamika Singh, Shreya Pandey, Afzal Azim Centre of Biomedical Research, Lucknow, India Impact: Integration of the metabolites and metabolic pathways identified in this study into ICU protocols may assist clinicians in recognizing patients at high risk for acute pancreatitis, thereby facilitating earlier and more personalized therapeutic interventions to enhance clinical outcomes.
		665-04-016. Hilbert Metasurfaces for Enhanced Preclinical MRI via Second Harmonic Generation Sergio Solis-Najera, Edith Tellez, Saul Rivera de la Luz, Jelena Lazovic Zinnanti, Alfredo Rodriguez Universidad Nacional Autonoma de Mexico, Queretaro, Mexico Impact: Demonstrates second-harmonic metasurfaces as an effective strategy for developing simpler, high-performance MRI coils.Introduction