Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

Predicting Neurologic Outcomes

Digital Poster

Pediatrics

Wednesday, 13 May 2026

Digital Posters Row G

14:35 - 15:30

Session Number: 566-04

No CME/CE Credit

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Imaging tools can be key contributors to prognostication and the prediction of neurological outcomes, particularly in newborns and children. This session will present data on a range of imaging modalities and explore their potential to predict outcomes across different neurological domains.

Skill Level: Intermediate

		566-04-001. Stratifying Cognitive Delay Risk in Preterm Infants with PWML by Structural Disconnection and Tract-Based Lesion Analysis Miaomiao Wang, zhichen wei, Congcong Liu, Pengxuan Bai, Xianjun Li, Zhujun Li, Shuai Wang, jian Yang The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China Impact: This work provides a clinically translatable decision rule for the early identification of preterm infants with punctate white matter lesions (PWML) who are at high risk for cognitive delay, to facilitate timely intervention and optimize resource allocation.
		566-04-002. Brain Microstructural Maturation in Preterm Infants Follows Distinct Trajectories Based on Brain Injury Severity Nahla Elsaid, Kyra Twohy, Krithika Surapaneni, Julius Ngwa, Kushal Kapse, Nickie Andescavage, Catherine Limperopoulos Children's National Hospital, Washington DC, United States of America Impact: This GAMM analysis of baseline microstructure and age-dependent maturation can convert diffusion MRI into a trajectory-based biomarker. This can help identify high-risk premature babies early, making it an effective intervention method.
		566-04-003. Intravenous Iron Supplementation During Pregnancy: Effects on Fetal Brain Development Assessed by Structural MRI Douglas Dean, Virupaxi Hattiholi, Mahesh Kamate, Moriah Thomason, Kiran Talekar, Anmol Patted, Simal Thind, Jesse Bradford-Rogers, Danielle DeSantis, Umesh Charantimath, Manjunath Somannavar, S Yogeshkumar, Rebecca Hartman, Benjamin Leiby, Roopa Bellad, Zubair Aghai, Michael Georgieff, Shivaprasad Goudar, Mrutyunjaya Bellad, Richard Derman University of Wisconsin - Madison, Madison, United States of America Impact: Fetal MRI revealed maternal iron supplementation formulation significantly impacts fetal thalamic volumes. Understanding iron supplementation strategies to support fetal brain development has important prenatal care implications in populations with high rates of iron deficiency.
		566-04-004. Postoperative Brain Changes in Newborns with Congenital Heart Disease Assessed by Source-Separated Magnetic Susceptibility MinJung Jang, Alexey Dimov, Jonathan Murnick, Tarif Choudhury, Qinghao Liang, Kushal Kapse, Anushree Kapse, Arindam RoyChoudhury, Vivien Yap, Mary Donofrio, Ranjini Srinivasan, Gloria Chiang, Yi Wang, Catherine Limperopoulos, Zungho Zun Weill Cornell Medicine, New York, United States of America Impact: This study demonstrated postoperative alterations in brain magnetic susceptibility in newborns with congenital heart disease and their associations with inflammation burden and neurodevelopmental outcomes, suggesting source-separated magnetic susceptibility as a potential biomarker of neuroinflammation and neurodevelopmental risk in this population.
		566-04-005. Multi-Center Lesion Distribution Mapping of Periventricular White Matter Injury in Infants With and Without Cerebral Palsy Tianjiao Chen, Zhen Jia, Xiaoyu Wang, Miaomiao Wang, Shuai Wang, Zhujun Li, Feng Shi, Xianjun Li, jian Yang The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China Impact: This study establishes the first multi-center, age-specific lesion probability atlas for infants with cerebral palsy. It provides reproducible biomarkers for early MRI-based risk prediction, enabling cross-site harmonization and advancing mechanistic understanding of corticospinal and sensorimotor network injury in early development.
		566-04-006. Alterations of network volume, topology and dynamics distinguish congenital from slowly progressive cerebellar ataxias Marta Gaviraghi, Anita Monteverdi, Sara Bulgheroni, Marta Mercati, Anna Nigri, Marina Grisoli, Stefano D’Arrigo, Claudia Gandini Wheeler-Kingshott, Claudia Casellato, Fulvia Palesi, Egidio D’Angelo University of Pavia, Pavia, Italy Impact: This study reveals distinct network alterations in Joubert syndrome and slowly progressive ataxias. MRI-derived parameters (volume, graph theory and brain dynamic simulations) predict clinical scores and differentiate patient groups, offering new insights into mechanisms of cerebellar dysfunction and compensatory reorganisation.
		566-04-007. Normative pediatric brain maturation analyses with MPnRAGE qR1 measurements in typical development and perinatal brain injury Jose Guerrero-Gonzalez, John Podczerwinski, Anna Lowe, Maren Schimek, Cameron Casey, Kellie Collins, Arun Karumattu Manattu, Veronika Mak, Steven Kecskemeti, Douglas Dean, Bernadette Gillick, Andrew Alexander University of Wisconsin - Madison, Madison, United States of America Impact: This pediatric-feasible, motion-robust normative qR1 relaxometry framework supports early detection and monitoring of atypical myelination. This work advances relaxometry toward clinically-feasible implementations, offering potentially useful biomarkers for improving early diagnoses and interventions in children at risk for developing cerebral palsy.
		566-04-008. Longitudinal trajectories of structural neurodevelopmental outcomes in young children who are HIV-exposed uninfected Simone Williams, Hayli Geffen, Zayaan Goolam Nabi, Michal Zieff, Jessica Ringshaw, Lauren Davel, Candice Knipe, Bokang Methola, Rabelani Negota, Khanyisa Nkubungu, Layla Bradford, Anele Khumalo, Thandeka Mazubane, Nwabisa Mlandu, Zamazimba Madi, Tembeka Mhlakwaphalwa, Reese Samuels, Donna Herr, Marlie Miles, Niall Bourke, Daniel Alexander, Derek Jones, Steven Williams, Catherine Wedderburn, Kirsten Donald University of Cape Town, South Africa, South Africa Impact: This study shows persistent structural brain alterations with perinatal HIV exposure and that CHEU with maternal viral suppression resemble brain volume trajectories in CHU, highlighting the importance of maternal ART and the need to optimize suppression timing and regimens.
		566-04-009. Altered IVIM-FWI Metrics in Pediatric Hematologic Cancer Survivors and Their Relationship with Cognitive Deficits Faye McKenna, Shounak Nandi, SIDDHARTH NAYAK, Sonya Henry, Roman Fleysher, Tim Duong Albert Einstein College of Medicine, Bronx, United States of America Impact: This study applied a novel three-compartment intravoxel incoherent motion free water imaging technique to study microvascular and microstructural changes in gray and white matter regions in pediatric cancer survivors and their association with cognitive tests.
		566-04-010. Leveraging Adult Brain Tumour AI Models to Predict Paediatric Neuro-Oncology Outcomes and Survival Tolou Shadbahr, James Ruffle, Liam Burrows, Ivano Palladino, Jenny Gains, Michael Roberts, Harpreet Hyare University of Helsinki, Helsinki, Finland Impact: Adult-trained deep learning models generalise effectively to paediatric brain tumour segmentation and survival prediction, despite age-related domain disparities. This approach could accelerate AI adoption in paediatric neuro-oncology by leveraging existing adult models through transfer learning.
		566-04-011. MRI in Clinical Practice: Non-contrast Rapid STAGE Imaging for Evaluation of Brain Abnormalities in Sturge-Weber Syndrome Scotty McKay, Yongsheng Chen, E. Mark Haacke, Yang Xuan, Aimee Luat, Csaba Juhasz Detroit Medical Center/Wayne State, Detroit, United States of America Impact: Rapid, non-contrast STAGE imaging accurately identifies vascular and parenchymal abnormalities in Sturge-Weber syndrome, correlates with epilepsy severity, and eliminates the need for sedation and gadolinium. This enables safer serial monitoring and standardized imaging critical for clinical management and collaborative research.
		566-04-012. Synthetic fractional anisotropy maps from conventional MRI for discriminating autism and global developmental delay Miaoyan Wang, Dandan Xu, Hongxuan Qiu, Xinmeng Yu, Zihang Cheng, Cailei Zhao, Wenbin Ji, Bo Peng, Yakang Dai, Haoxiang Jiang Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, China Impact: Synthetic fractional anisotropy maps allow early detection of microstructural changes and serve as a feasible alternative to diffusion tensor imaging for distinguishing autism spectrum disorder from global developmental delay, offering a supplementary tool for clinical decision making.
		566-04-013. Using Linked Independent Component Analysis to Identify Multimodal Biomarkers of Perinatal HIV and Early ART at age 11 years Siobhán Stevenson, Joanah Madzime, Peter Torre, Barbara Laughton, Andre van der Kouwe, Ernesta Meintjes, Frances Robertson, Isaac Khobo University of Cape Town, Cape Town, South Africa Impact: This study identifies regions of the brain where neurodevelopment is impacted by perinatally acquired HIV and early ART in 11-year-old children. This could allow for better understanding of the neurological effects of perinatally acquired HIV in children.
		566-04-014. Altered DTI-ALPS Index after surgical treatment for pediatric obstructive sleep apnea Weihao Yan, Yuchuan Fu, Lu Han Impact: The findings in this study suggest that OSA can lead to both sleep architecture disruption and glymphatic system impairment in children, and that early surgical intervention may facilitate the recovery of glymphatic function.