Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition • 09-14 May 2026

Digital Poster

Fetal and Neonatal Imaging

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Fetal and Neonatal Imaging
Digital Poster
Pediatrics
Wednesday, 13 May 2026
Digital Posters Row C
16:00 - 16:55
Session Number: 562-05
No CME/CE Credit
The Fetal and Neonatal Neuroimaging session will highlight emerging research in fetal and newborn imaging, including advances in scanner hardware and the development of specialized post-processing tools tailored to these early-life populations. Presentations will feature data acquired across multiple field strengths, including 7T, and will cover a range of imaging modalities.
Skill Level: Advanced

  Figure 562-05-001.  Multi-Organ Volumetric Growth Trajectories in Fetuses with Hydronephrosis
Junwei Huang, Kasidit Anmahapong, Haoxiang Li, Mingxuan Liu, Juncheng Zhu, Hongjia Yang, YIJIN LI, Yingqi Hao, Fenglin Jia, Yi Liao, Haibo Qu, Qiyuan Tian
Tsinghua University, Beijing, China
Impact: In this case-control study, hydronephrotic fetuses exhibited significant renal pelvis dilation and increased brain, liver and placental volumes, suggesting potential impact of hydronephrosis on global fetal development.
  Figure 562-05-002.  Early Music Exposure Enhances Claustrum Microstructural Maturation in Preterm Infants: Evidence from Diffusion MRI
Kinkini Bhadra, Andrew Boehringer, Cecilia Naboni, Milena Apostolova, Manuela Filippa, Joana Sa de Almeida, Petra Hüppi
Gynaecology and Obstetrics, Geneva, Switzerland
Impact: We demonstrate that early structured music exposure may accelerate claustrum maturation in preterm infants, enhancing its microstructural organization. These findings highlight music as a promising, non-invasive intervention to support subcortical development and mitigate neurodevelopmental vulnerabilities associated with premature birth.
  Figure 562-05-003.  RF Safety Evaluation of Infant Neuroimaging at 5.0 T
Zhujun Li, Miaomiao Wang, Pengxuan Bai, SHAOXIN xiang, jian Yang
Xi'an Jiaotong University, Xi'an, China
Impact: This study provides the first quantitative evidence that 5 T infant neuro-MRI can be performed safely, supporting clinical translation of ultra-high-field systems and informing sequence optimization and RF-safety supervision for pediatric imaging.
  Figure 562-05-004.  Quantitative MRI Biomarkers Reveal Spatiotemporal Patterns of Fetal Adipose Tissue Development and Brown-to-White Fat Convers
Shuzhen Ma, Yuchen Liu, Chunran Yang, Hongbo Pu, Yangmei Pu, Zaihang Yin, Min Kang
Sichuan Provincial Maternity and Child Health Care Hospital, Chengdu, China
Impact: This study provides novel insights into the spatiotemporal dynamics of fetal adipose tissue development and the transition from brown adipose tissue to white adipose tissue, which helps early identification and precision management of metabolic health risks during fetal development.
  Figure 562-05-005.  Development of Structure-Function Coupling in the Very Preterm Newborn Brain and Effects of Early Music Exposure
Andrew Boehringer, Joana Sa de Almeida, Arben Miftari, Elda Fischi-Gomez, Manon Durand-Ruel, Dimitri Van De Ville, Petra Hüppi
University of Geneva, Faculty of Medicine, Geneva, Switzerland
Impact: Structure-function relationship matures during preterm development towards adult-like patterns through term-equivalent-age. This maturation exceeds that of full-term infants, and is further enhanced by early music exposure, suggesting early environmental impacts on structure-function maturation.
  Figure 562-05-006.  Towards real-time navigation in diagnostic fetal brain MRI
Ramya Muthukrishnan, Paul wighton, Robert Frost, Andre van der Kouwe, Aryn Lee, Elfar Adalsteinsson, Patricia Grant, Polina Golland, Borjan Gagoski
Massachusetts Institute of Technology, Cambridge, United States of America
Impact: We present a feedback loop system for automated prescription of imaging slices that account for the fetal head motion in real time. This work promises to significantly improve radiological assessments, reduce scan time, and alleviate pregnant patients’ discomfort.
  Figure 562-05-007.  White Matter Development Following Maternal Iron Supplementation: A Diffusion MRI Study of Intravenous versus Oral Iron
Douglas Dean, Virupaxi Hattiholi, Mahesh Kamate, Moriah Thomason, Kiran Talekar, Anmol Patted, Simal Thind, Jesse Bradford-Rogers, Danielle DeSantis, Umesh Charantimath, Manjunath Somannavar, S Yogeshkumar, Rebecca Hartman, Benjamin Leiby, Roopa Bellad, Zubair Aghai, Michael Georgieff, Shivaprasad Goudar, Mrutyunjaya Bellad, Richard Derman
University of Wisconsin - Madison, Madison, United States of America
Impact: This study provides evidence that maternal iron supplementation formulation influences infant white matter microstructural development. Findings suggest intravenous iron supplementation may optimize iron delivery during critical neurodevelopmental periods, informing clinical guidelines for managing iron deficiency in vulnerable populations worldwide.
  Figure 562-05-008.  Clinical Feasibility of NeSVoR 3D Fetal Brain Reconstruction Across Realistic Fetal Motion
Yuchen Liu, Shuzhen Ma, Huilou Liang, Yuhui Xiong, Bing Wu, Min Kang
GE HealthCare MR Research, Beijing, China
Impact: This study validates NeSVoR using real in vivo fetal motion, filling gaps left by synthetic motion tests. It quantifies reconstruction stability across clinical motion intensities, advancing algorithm generalizability, guiding MRI acquisition, and ensuring reliable fetal brain imaging for clinical use.
  Figure 562-05-009.  Lac/NAA Ratio Threshold Using sLASER-144 Single-Voxel MRS and ADC Scores in Neonates with Hypoxic-Ischemic Encephalopathy
Hennie Kuipers, Martine C.M. Lagerweij, Jochen A.C. van Osch, Isabell Steinseifer, Leo Kluijtmans, Laura de Jong, Martijn Boomsma, Susanne Mulder-de Tollenaer
Isala Hospital, Zwolle, Netherlands
Impact: Early follow-up–based Lac/NAA cutoffs from sLASER-144 MRS provide neonatologists with greater certainty, as elevated ratios can confirm metabolic brain injury. When used alongside ADC values, Lac/NAA serves as a complementary parameter to improve prognostic accuracy and guide early interventions.
  Figure 562-05-010.  T2* based Functional Mapping of the neonatal brain using Echo Planar Time-resolved Imaging at 7 Tesla
Courtney Ormrod, David Leitão, Daniel West, Antonia Massmann, Jucha Willers Moore, Inka Granlund, Lucy Billimoria, Pierluigi Di Cio, Philippa Bridgen, Alexandra Bonthrone, Jonathan O'Muircheartaigh, Jo Hajnal, Jian Wu, Zijing Dong, Fuyixue Wang, Tomoki Arichi, Shaihan Malik
King's College London, London, United Kingdom
Impact: We demonstrate task-elicited changes in T2* using EPTI at ultra-high field in infants for the first time. This more quantitative functional measurement enables robust inter-subject analysis and can advance understanding of early neonatal neurovascular development.
  Figure 562-05-011.  Diffusion Tensor MRI Thermometry in Preterm Neonates: Validation of a CSF-Based Model Toward Fetal Temperature Estimation
Nahla Elsaid, Nickie Andescavage, Catherine Limperopoulos
Children's National Hospital, Washington DC, United States of America
Impact: We demonstrated the first phase of validation of fetal diffusion-based thermometry using preterm CSF, a surrogate for fetal CSF. This can facilitate the transition to fetal diffusion-based thermometry and future noninvasive quantitative monitoring of fetal temperature, thereby enhancing fetal-maternal safety.
  Figure 562-05-012.  First in-vivo brain MRI of an awake infant on a compact helium-free 1.5T pediatric scanner
Anne Slawig, Peter Hömmen, Alexander Gussew, Stefan Röll, Roland Haase, Walter Wohlgemuth
Medical Physics Group, University Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Germany
Impact: Bedside MRI of awake infants is feasible using the compact helium-free 1.5T pediatric scanner. Diagnostic image quality without sedation enables safe, flexible neuroimaging directly next to pediatric ICU, reducing transport risks and expanding access to radiation-free imaging in vulnerable patients.
  Figure 562-05-013.  First External Validation of Automated Slice-to-Volume Reconstruction and Automated Lung Volumetry in Fetal MR Imaging
Rabea Klaar, Sara Neves Silva, Gloria Biechele, Sarah Schlaeger, Alina Priller, Alena Uus, Jana Hutter, Sophia Stoecklein
LMU University Hospital, LMU Munich, Munich, Germany
Impact: The clinical validation of automated pipelines for accurate slice-to-volume reconstruction, lung segmentation and volumetry of motion-corrupted fetal MRI-scans, demonstrated here in 37 cases, is a crucial step to identify the potential of the inclusion of these pipelines in clinical workflows.
  Figure 562-05-014.  GABA Measurements with and without Macromolecule Suppression in the Neonatal Brain
Steve Hui, Nickie Andescavage, Kushal Kapse, Muhammad Saleh, Richard AE Edden, Catherine Limperopoulos
Children's National Hospital, Washington DC, United States of America
Impact: To our knowledge, this is the first study to report co-edited macromolecules that contaminate GABA+ measurements using MEGA-PRESS in the neonatal brain. Results offer a better understanding of the severity of co-editing impact and provide insight into developing correction methods.
  Figure 562-05-015.  Multi-echo spiral acquisition for rapid, sub-millimetre neonatal R2* whole brain mapping at 7T
David Leitão, Chiara Casella, Antonia Massmann, Jucha Willers Moore, Alena Uus, Inka Granlund, Lucy Billimoria, Ines Tomazinho, Pierluigi Di Cio, Philippa Bridgen, Alexandra Bonthrone, Jonathon O'Muircheartaigh, Jo Hajnal, Tomoki Arichi, Shaihan Malik
King's College London, London, United Kingdom
Impact: This study demonstrates rapid, sub-millimetre neonatal R2* mapping at 7T using multi-echo spiral imaging. The method enables whole-brain quantitative mapping within minutes, advancing ultra-high field neonatal MRI for studying early brain microstructure and developmental or pathological alterations.

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