Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

MRI in Infectious Diseases

Traditional Poster

Neuro B

Tuesday, 12 May 2026

Traditional Posters | Exhibition Hall

16:00 - 16:55

Session Number: 470-09

No CME/CE Credit

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This session presents quantitative MRI studies examining brain alterations associated with HIV, cannabis use, antiretroviral exposure, and COVID-19. Using spectroscopy, diffusion imaging, and microstructural metrics, the talks highlight metabolic, inflammatory, and white matter changes, advancing neuroimaging biomarkers for infection-related, substance-associated, and post-viral neurological effects.

		470-09-139. Effect of Cannabis Use on Brain Metabolites in People with HIV Using Whole-Brain Magnetic Resonance Spectroscopic Imaging Teddy Salan, Fernando Moradel Cano, Denise Vidot, Bria-Necole Diggs, Dario Ayala, Sulaiman Sheriff, Hanzhi Gao, Lisa Reidy, Eva Widerstrom-Noga, Suresh Pallikkuth, Allan Rodriguez, Robert Cook, Varan Govind University of Miami, Miami, United States of America Impact: Cannabis consumption in people with HIV has been shown to significantly alter neurometabolite levels across the whole brain, as revealed by our advanced whole-brain MR Spectroscopic Imaging technique, uncovering complex effects on neuronal function, neurotransmitter systems, and neuroinflammation.
		470-09-140. Combined and Differential effects of Cannabis Consumption and HIV on Brain White Matter using DTI-DKI and Free-Water Imaging Teddy Salan, Fernando Moradel Cano, Denise Vidot, Bria-Necole Diggs, Dario Ayala, Hanzhi Gao, Lisa Reidy, Eva Widerstrom-Noga, Suresh Pallikkuth, Allan Rodriguez, Robert Cook, Varan Govind University of Miami, Miami, United States of America Impact: Results from DTI and DKI, with Free-water-elimination, show that cannabis consumption and HIV are significantly associated with injury to brain white-matter and neuroinflammation. However, cannabis may play a differential role in people with HIV compared to people without HIV.
		470-09-141. Characterization of regional variations in brain temperature and metabolite concentrations in people with HIV Kathryn Malone, Kaundinya Gopinath, Howard Pope Jr., Alicarmen Alvarez, Minh Ly Nguyen, Taylor Harrison, Christina Gavegnano, Vincent Marconi, William Tyor, Candace Fleischer Georgia Institute of Technology and Emory University, Atlanta, United States of America Impact: Regional differences in both brain temperature and metabolites were observed in people with well-controlled HIV, supporting further development of imaging biomarkers to understand the effects of HIV in the central nervous system.
		470-09-142. Quantitative MRI detects antiretroviral drug-induced maturation delays in cerebral organoids Manjeet Kumar, Christine Adalikwu, Jhyama Gurung, Yutong Liu, Aditya Bade, Balasrinivasa Sajja University of Nebraska Medical Center, Omaha, United States of America Impact: Quantitative MRI of cerebral organoids showed that dolutegravir exposure significantly increased ADC values, indicating impaired neuronal maturation. These results establish ADC mapping as a sensitive imaging biomarker for evaluating antiretroviral drug–induced neurotoxicity during fetal brain development.
		470-09-143. Mild COVID-19 Is Associated with Microstructural Brain Changes from Pre-Pandemic Baseline in Healthy Young Adults. Luca Bremner, Roman Fleysher, Kenny Ye, Katherine Ho, Molly Zimmerman, Mimi Kim, Shalika Fnu, Ariana Olivares, Richard Lipton, Johanna Daily, Michael Lipton Columbia University Irving Medical Center, New York, United States of America Impact: This study identified localized COVID-19-associated decline in diffusion measures of white matter microstructure that persisted after the acute stages of infection. These could serve as diagnostic biomarkers for long-COVID cognitive symptoms in young adults.
		470-09-144. White Matter Microstructural Alterations in Neurological Post-Acute Sequelae of COVID-19 Indicate Neuroinflammation Chuan Huang, Xinlan Zhang, Jia Ying, Zennur Sekendiz, Ashley Fontana, Xiaohua Yang, Steven West, Paul Vaska, Sean Clouston, Benjamin Luft Emory University, Atlanta, United States of America Impact: Diffusion MRI revealed tract-specific WM disruption consistent with chronic neuroinflammation in N-PASC. These imaging markers track behavioral and executive deficits and may aid patient stratification and longitudinal monitoring in post-COVID neuroimaging studies.
		470-09-145. Widespread cortical diffusion MRI changes correlate with systemic inflammation in Long COVID Ana Silva, Hamza Farooq, Christophe Lenglet, James Joers, Katherine Gundry, Alfredo Lorente, Jeromy Thotland, Dinesh Deelchand, Young Park, Xiufeng Li, Georgios Manousakis, Abby Metzler, Lynn Eberly, June Kendall-Thomas, Orhun Kantarci, Arvin Arani, Merve Atik, Matthew Senjem, Burcu Zeydan, Keenan Byrne, Lauren Pollak, Meher Juttukonda, David Salat, Janet Sherman, Shibani Mukerji, G. Kyle Harrold, Sevil Yasar, Mehreen Nabi, Sana Rehman, Christof Karmonik, Syed A. Gillani10 Gillani, Valerie Flores, Rachel Davis, Tetsuo Ashizawa, Peter Barker, Eva-Maria Ratai, Kejal Kantarci, Gulin Oz Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, United States of America Impact: Our findings support persistent, chemokine-driven inflammation nearly 2 years after infection. The observed association between peripheral immune activation and cortical microstructural changes underscores the value of integrating plasma proteomics with advanced diffusion MRI to elucidate the pathobiology of long COVID.
		470-09-146. MRI in Clinical Practice: Diagnosis of Cerebral Tuberculous Abscess Milkias Balcha MCM hospital, Addis Ababa, Ethiopia Impact: The MRI findings in this case had a high level of diagnostic certainty which significantly impacted the clinical decision making and immediate initiation of treatment. It also helped to avoid doing an invasive procedure (craniotomy) to get a tissue biopsy.
		470-09-147. MRI in Clinical Practice: MRI in Clinical Practice: Paralysis Reversed in TB Spondylitis of multiple site involvement. Adaobi Emegoakor, Obinna Obiegbu, Eric Umeh, Chinasa Kalaiwo, Kanayo Obieje, Amal Saleh Nour Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria Impact: This case highlights MRI’s unmatched value in diagnosing and treating spinal tuberculosis seen at two sites and complicated by epidural abscess. Its ability to define the full disease extent enables timely intervention and improved outcomes, particularly in resource-limited clinical environments.