Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Innovations in Contrast Mechanisms for MRI

Innovations in Contrast Mechanisms for MRI

Oral

Contrast Mechanisms

Monday, 11 May 2026

Hall 1A

16:10 - 18:00

Moderators: Sudhir Pathak & Gareth Barker

Session Number: 301-04

CME/CE Credit Available

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This session highlights recent advances in novel MRI contrast mechanisms including physical principles, technical development, and emerging applications.

16:10		301-04-001. Joint Spatiotemporal Phase Unwrapping and Background Field Removal for QSM via Physics-Constrained Optimization Asli Alpman, Giulia Debiasi, Chunlei Liu University of California, Berkeley, United States of America Impact: The proposed method enables temporally consistent, spatially harmonic background phase estimation without explicit unwrapping, improving QSM in regions with strong field distortions, and providing a foundation for more accurate tissue susceptibility and microstructural characterization.
16:21		301-04-002. Simultaneous reconstruction of longitudinal QSM data (Longitudinal-QSM) Jiye Kim, Hwihun Jeong, Taechang Kim, Yangsean Choi, Jongho Lee Seoul National University, Seoul, Korea, Republic of Impact: This study presents a novel simultaneous reconstruction framework for longitudinal QSM by jointly estimating susceptibility maps from two time points. The proposed method improves reproducibility and sensitivity across scans, enabling more reliable monitoring of susceptibility alterations in the brain.
16:32		301-04-003. Multimodal MRI Framework for Cross-Species Cerebellar Mapping and Atlas Construction in Marmoset, Macaque, and Human. Kadharbatcha Saleem, Alexandru Avram, Daniel Glen, Peter Basser Eunice Kennedy Shriver - National Institute of Child Health and Human Development (NICHD), Bethesda, United States of America Impact: This work develops a standardized multimodal MRI framework that combines structural, diffusion, and fiber orientation modalities for high-resolution cerebellar mapping and atlas construction across marmoset, macaque, and human brains. This enables cross-species registration, segmentation, and comparative analysis of cerebellar microstructure.
16:43		301-04-004. Investigation of Dipolar Order Relaxation Times (T1D) and ihMT in Lipid Model Membranes Niklas Wallstein, Axelle Grélard, Olivier Girard, Erick Dufourc, Antoine Loquet, Guillaume Duhamel Aix Marseille Univ, Marseille, France Impact: Both of the investigated lipid model systems reveal a high degree of complexity underlying the observed (ih)MT effects, and indicate the presence of several distinct dipolar reservoirs. Adding cerebrosides to lipid membranes considerably influences T_1D, and consequently non-aqueous ihMT.
16:54		301-04-005. Time and orientation-dependent transverse relaxation from magnetic susceptibility of realistic white matter microstructure Anders Sandgaard, Rafael Neto Henriques, Noam Shemesh, Sune Jespersen Aarhus University, Aarhus, Denmark Impact: This study demonstrates how realistic white-matter geometry shapes time- and orientation-dependent transverse relaxation. These insights refine susceptibility-based relaxation modeling and may enable development of more specific and biologically grounded neuroimaging biomarkers for white-matter disease.
17:05		301-04-006. Myelin Water Fraction mapping from T1 relaxometry for multisite datasets harmonization Marta Lancione, Matteo Cencini, Domenico Aquino, Cristina Baldoli, Graziella Donatelli, Maurizio Elia, Francesco Ghielmetti, Domenico Montanaro, Ilaria Neri, Anna Nigri, Rosa Pasquariello, Salvatore Pettinato, Salvatore Romano, Alessandro Sbrizzi, Paola Scifo, Oscar van der Heide, Edwin Versteeg, Laura Biagi, Michela Tosetti IRCCS Fondazione Stella Maris, Pisa, Italy Impact: The proposed framework enables the aggregation of non-harmonized T1 maps across vendors, acquisition methods, and magnetic field strengths, producing quantitative and biologically meaningful synthetic myelin water fraction maps. This approach increases reproducibility and preserves diagnostic sensitivity, supporting retrospective multicenter studies.
17:16		301-04-007. Study of water permeability across cellular membranes through an MRI-CEST method Chiara Papi, Daria Giulia Platania, Chiara Borghesi, Alessia Corrado, Antonino Di Lorenzo, Laura Conti, Silvio Aime, Giuseppe Ferrauto, Enza Di Gregorio University of Turin, Turin, Italy Impact: This method enables quantification of tumor cell membrane water permeability using clinically approved MRI agents, providing an early biomarker of aggressiveness and therapeutic response. It offers researchers and clinicians a novel tool for functional tumor characterization and treatment monitoring.
17:27		301-04-008. Fat-corrected CEST Imaging of the Human Liver at 7T Petr Menshchikov, Petr Bulanov, Neele Kempa, Philip Boyd, Mark Ladd, Peter Bachert, Max Lutz, Sebastian Schmitter, Andreas Korzowski German Cancer Research Center (DKFZ), Heidelberg, Germany Impact: The FATLESS fat correction method combined with B₁⁺ shimming enables robust in vivo quantification of CEST contrasts in the liver at 7 T, paving the way for non-invasive assessment of metabolic alterations, inflammation, fibrosis, and oncologic applications.
17:38		301-04-009. Metabolic Assessment of Fatty Liver Disease in Humans Using Hyperpolarized [1-¹³C]Pyruvate MRI Yaewon Kim, Hsin-Yu Chen, Jeremy Gordon, Aras Mattis, Jacquelyn Maher, Bilal Hameed, Robert Bok, Dan Vigneron, Cornelius von Morze, Michael Ohliger University Of California, San Francisco (UCSF), United States of America Impact: This study demonstrates noninvasive assessment of hepatic metabolism using hyperpolarized [1-¹³C]pyruvate MRI, enabling direct measurement of metabolic flux in MASLD and MASH. The approach may provide a sensitive biomarker for early disease activity and treatment response in fatty liver disease.
17:49		301-04-010. Etiology-Specific Optimal Timing for MR Lymphangiography in Lower Extremity Lymphedema zhenyu shu, Zihan Zhang, Dewang Mao, Qiaowei Song, Youmao Zheng, Qingqing Wen Center for Rehabilitation Medicine, Department of Radiology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, China Impact: Etiology-tailored MRL timing can improve image quality, reducing scan time while ensuring optimal visualization for precise surgical planning.