Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Advances in Chemical Exchange MRI: CEST, APT, and NOE I

Advances in Chemical Exchange MRI: CEST, APT, and NOE I

Digital Poster

Contrast Mechanisms

Thursday, 14 May 2026

Digital Posters Row A

13:40 - 14:35

Session Number: 660-03

No CME/CE Credit

Similar Sessions

This session presents emerging applications enabled by advances in CEST, APT, and NOE imaging.

		660-03-001. CEST imaging of natural killer cell-based immunotherapy for brain tumor Tian ZHANG, Hang DENG, Hao ZHANG, Yuan ZONG, Ai LYU, Wai Po CHONG, Kannie W. Y. Chan City University of Hong Kong, Hong Kong, China Impact: Immunotherapy of natural killer cells has shown promises in treating GBM, the most lethal form of brain tumors. We monitored the injectable hydrogel NK cell therapy in brain tumor-bearing mice using MRI and observed enhanced treatment outcome using CEST MRI.
		660-03-002. RF Power Amplifier Drift Compensation for CEST MRI Ali Aghaeifar, Desmond Tse, Dimo Ivanov, Klaus Scheffler, Patrick Liebig MR Collaborations, Siemens Healthineers, Erlangen, Germany Impact: RF power amplifier drift correction can shorten CEST imaging by removing the stabilizer scan and improve reproducibility of acquisitions.
		660-03-003. A Deep Learning Framework for Accelerated NEMR Fitting with Optimal Frequency Offset Selection Yizhe Shi, Yuyan Wang, Jianping Xu, Jibin Tang, Tongling Jiang, Shanshan Lu, Yi-Cheng Hsu, Yi Zhang College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China Impact: This work accelerates NEMR fitting and optimizes the selection of scanning frequency offsets using a deep learning framework, thereby facilitating the clinical translation of the NEMR method.
		660-03-004. B1+ Correction in Chemical Exchange Saturation Transfer at 7T via Bilateral Orthogonality Generative Acquisitions Method Celik Boga, Yuxin Lan, Anke Henning University of Texas Southwestern Medical Center, Dallas, United States of America Impact: Utilization of the Bilateral Orthogonality Generative Acquisitions method for CEST at 7T addresses the transmit field inhomogeneity issues without additional calibration measurements or calculations; hence it can ease the clinical translation of CEST in ultra high field MRI.
		660-03-005. Robust Distortion Self-Correction in CEST-EPI Using Single-Shot Blip-Rewound Acquisition and Multi-TE Joint Reconstruction Xiaorui Xu, Jiawen Wang, Shihui Chen, Huabin Zhang, Ziyan Wang, Jianpan Huang The University of Hong Kong, Hong Kong, China Impact: This study proposed a single-shot blip-rewound CEST-EPI technique that enables robust distortion self-correction especially under sparsely sampled offsets. e.g. 7-point APTw. The proposed method may facilitate broader clinical translation of CEST-EPI and inspire improved correction strategies for other EPI-based techniques.
		660-03-006. Integrated Clinical and Multiparametric MRI Histogram Models for Preoperative Prediction of Tumor Budding in Rectal Cancer Yingying Zhang, Huang Jinghuan Huang, Gang Huang Gansu University of Chinese Medicine, Lanzhou, China Impact: Combining amide proton transfer–weighted (APTw) and apparent diffusion coefficient (ADC) histogram features with clinical biomarkers enables accurate and noninvasive preoperative prediction of tumor budding (TB) grade in rectal cancer, offering potential guidance for risk stratification and individualized treatment planning.
		660-03-007. Dual-Breathing CrCEST: A Novel Imaging Method to Distinguish Oxygen-Delivery and Utilization in Exercised Muscle Blake Benyard, Abeer Mathur, Dipak Roy, Anshuman Swain, Sunil Khokhar, Narayan Datt Soni, neil wilson, Mohammad Haris, Payman Zamani, Ravinder Reddy, Dushyant Kumar University of Pennsylvania, Philadelphia, United States of America Impact: Dual-breathing CrCEST imaging has the potential to isolate oxygen-delivery limits from intrinsic oxidative dysfunction underlying slowed post-exercise creatine recovery, advancing CrCEST from an oxidative phosphorylation (OXPHOS) marker to a mechanistic biomarker of metabolic resilience and early impairment detection.
		660-03-008. Acid-Responsive Fe₃O₄@MnO₂@CMCS Nanoprobes Enable Dual-Parametric and CEST MRI for Tumor Microenvironment Imaging Fei-Xiang Hu, Pu-Yeh Wu, Wei-Jun Peng, Tong Tong Fudan University Shanghai Cancer Center, Shanghai, China Impact: This work reveals the mechanism by which acid-triggered Mn²⁺ release modulates CEST and dual MRI contrast simultaneously, offering a quantitative strategy for imaging tumor microenvironments using responsive nanoprobes.
		660-03-009. Molecular MRI Biomarker Development for the Early Diagnosis of Alzheimer’s Disease Zongpai Zhang, Jingpu Wu, Isabel Rios Pulgar, Keyi Chai, Puyang Wang, Shanshan Jiang, Arnold Bakker, Jinyuan Zhou Johns Hopkins University School of Medicine, Baltimore, United States of America Impact: APT imaging can serve as a sensitive molecular MRI biomarker for detecting soluble oligomers that are a key feature of AD. It holds promise for improving early diagnosis, monitoring disease progression, and evaluating therapeutic response in AD.
		660-03-010. Preoperative prediction of macrotrabecular-massive hepatocellular carcinoma using amide proton transfer-weighted MRI Zhaorong Wang, Jiale Hang, Furong Wan, Yingying Peng, Jie Shi, Jing Ye, Xianfu Luo Dalian Medical University, Dalian, China Impact: APTw MRI provides complementary biochemical information to conventional MRI, significantly improving the accuracy of diagnosing MTM-HCC. It may serve as a promising noninvasive biomarker for risk stratification and individualized treatment planning in hepatocellular carcinoma.
		660-03-011. Removal of direct water saturation in CEST MRI using spectral editing Qing Zeng, Peter van Zijl, Nirbhay Yadav Johns Hopkins University School of Medicine, Baltimore, United States of America Impact: DS-removal based on multi-offset multi-B₁ signal scale matching can facilitate CEST signal extraction and quantification from Z-spectral data, removing the need for MTR_asym analysis or lineshape fitting methods.
		660-03-012. Motion-Robust and Geometrically-Accurate CEST MR Fingerprinting in the Brain using Golden-Angle Radial Sampling Ouri Cohen, Ricardo Otazo Memorial Sloan Kettering Cancer Center, New York, United States of America Impact: The proposed radial CEST-MRF technique enables accurate and reproducible motion-robust whole-brain quantitative CEST imaging with reduced geometric distortions in clinically relevant scan times that can be used for improved diagnosis and treatment response monitoring of brain tumors.
		660-03-013. Characterizing human brain glycogen concentration in Lafora Disease by 2-step Lorentzian fitting of 7T GlycoNOE measurement Yuxin Lan, Mayank Verma, Berge Minassian, Nirbhay Yadav, Anke Henning University of Texas Southwestern Medical Center, Dallas, United States of America Impact: Quantification of GlycoNOE effect through 2-step Lorentzian fitting from 7T CEST data is clinically beneficial to characterize glycogen concentration in the brain for Lafora patients enrolled in a clinical trial of ION283 therapy.