Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Neuroimaging Biomarkers of Aging, Vascular Health, and Dementia

Neuroimaging Biomarkers of Aging, Vascular Health, and Dementia

Digital Poster

Neuro A

Monday, 11 May 2026

Digital Posters Row C

17:05 - 18:00

Session Number: 362-06

No CME/CE Credit

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This session highlights advanced neuroimaging approaches to investigate vascular, metabolic, and microstructural brain changes associated with aging and neurodegenerative disease. Emphasis is placed on linking cerebral perfusion, amyloid burden, connectivity, and tissue integrity to cognitive decline and Alzheimer’s‑related pathophysiology.

		362-06-001. Characterizing the relationship between cerebral perfusion and amyloid PET Centiloids in Alzheimer’s disease Yufei Zhu, Qinyang Shou, Xinhui Wang, Arthur Toga, Vasilis Marmarelis, Meredith Braskie, Helena Chui, Danny Wang USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States of America Impact: Our finding of lower arterial spin labeling (ASL) cerebral blood flow (CBF) in key AD-related regions correlating with higher global amyloid-beta (Aβ) PET in Centiloids suggests that Aβ accumulation is one of the factors contributing to reduced CBF in AD.
		362-06-002. Older Age and Heart Disease are Associated with a Faster Increase in ARTS, an In-Vivo Marker of Cerebral Arteriolosclerosis Ana Tomash, Khalid Saifullah, Md Tahmid Yasar, Maude Wagner, Arnold Evia, David Bennett, Julie Schneider, Konstantinos Arfanakis Impact: This longitudinal study of ARTS enhances our understanding of the factors that are associated with a different rate of change in this marker, and identifies older age and heart disease as factors that may be linked to faster arteriolar deterioration.
		362-06-003. Aging Effects on Nigrostriatal Structure, Hemodynamics, and Connectivity: Implications for Parkinson’s Disease Jiaqi Wen, Chenyang Li, Li Jiang, Huize Pang, Toby Nguyen, Xiaojun Xu, Yulin Ge NYU Grossman School of Medicine, New York, United States of America Impact: These findings reveal early nigrostriatal vulnerability with aging and provide a sensitive framework for detecting preclinical neural changes that may predispose the aging brain to Parkinsonian degeneration.
		362-06-004. Microstructural Characterization of Hippocampal Subfields in Midlife APOE e4-Carriers using Soma and Neurite Density Imaging Robert Davis, Bradley Karat, Louisa Wood, Anne Corbett, Marco Palombo, Derek Jones, Lucy Hiscox Cardiff University, Cardiff, United Kingdom Impact: Healthy midlife APOE ε4-carriers showed reduced cell-body signal fractions in the right anterior CA2/CA3 hippocampus, indicating localised microstructural vulnerability associated with Alzheimer’s disease genetic risk. SANDI has potential to detect subtle cellular alterations linked to early pathophysiology.
		362-06-005. A Connectome Analysis Linking Brain Structure and Pathophysiological Measures Toward Early Alzheimer’s Detection Rain Xie, Syam Gadde, Christopher Petty, Trong-Kha Truong, Andy Liu, Bethany Hsia, Michael Devinney, Kim Johnson, Heather Whitson, Allen Song Duke University, Durham, United States of America Impact: This expanded connectome analysis integrates brain and pathophysiological measures to map intra- and cross-modality relationships relevant in early stages of AD. The resulting maps highlight multimodal connectivity patterns that may enhance our understanding of the relationships between preclinical neurodegenerative processes.
		362-06-006. Quantifying Axonal Microstructural Changes in Aging Using Ultra-High Gradient Diffusion MRI Aneri Bhatt, Hansol Lee, Kwok-Shing Chan, Yixin Ma, Jeremy Ford, Susie Huang Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America Impact: Ultra-high gradient diffusion MRI enables robust estimation of axonal integrity in the aging brain, promising to facilitate earlier detection of age-related changes before macrostructural changes and symptoms of neurodegeneration are evident.
		362-06-007. Impact of childhood adversity on age-related changes of brain metabolites and tissue parameters using 1H MRS and MPM at 3T Ralf Mekle, Martin Bauer, Lara Fleck, Alma Kathmann, Dinesh Deelchand, Claudia Buss, Sonja Entringer, Jochen Fiebach, Matthias Endres, Christine Heim Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Stroke Research Berlin, Berlin, Germany Impact: Gaining insight into mid- to long-term effects of early-life stress (ELS) on the adult human brain at a metabolic and microstructural level can guide personalized treatment approaches to counteract potential pathologies, such as neuroinflammation, neurodegeneration or accelerated cognitive decline.
		362-06-008. Regional cerebral blood flow changes at specific time-point during amyloid-targeted therapy for Alzheimer's disease patients Eva Cheung, Ka Fung Henry Mak, Yat-Fung Shea, Patrick Ka-Chun Chiu, Koon Chan, Kyongtae Ty Bae The University of Hong Kong, Hong Kong, China Impact: It highlights the use of pseudo continuous - arterial spin labelling (pcASL) MRI as an imaging biomarker for amyloid-targeted therapy monitoring
		362-06-009. GABA+, Glx and Glutathione vary by age, sex and brain region in a sample of healthy adults Alison Wilson, Julie Joyce, Leah Mercier, Mehak Stokoe, Parker La, Tiffany Bell, Chantel Debert, Ashley Harris University of Calgary, Calgary, Canada Impact: Without appropriate normative data, imaging research in clinical populations is not meaningful. This study generated MRS data from difficult to resolve metabolites in a cohort of healthy adults. Data from this investigation provides important reference information for clinical comparisons.
		362-06-010. Progressive Disruptions in Glymphatic Function and Dynamic Functional Connectivity Across the Alzheimer's Disease Spectrum yan shi, Chenyang Geng, Renpuchi Ci, Ning Zheng, Yuanyuan Qin Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1095, Wuhan, China Impact: This study reveals that glymphatic dysfunction, evident from the SCD stage, leads to cognitive decline in Alzheimer's disease by disrupting dynamic network function, thus identifying key biomarkers and therapeutic targets for early intervention.
		362-06-011. The TREM2 R62H variant relates to differences in brain structure across the Alzheimer’s disease continuum Katherine Koenig, James Leverenz, Lynn Bekris, Kunio Nakamura, Mark Lowe, Tara DeSilva Cleveland Clinic, Cleveland, United States of America Impact: This is the first investigation of the impact of the TREM2 R62H variant on cognitively normal carriers. Our findings point to early brain changes that may point to mechanistic contributors to Alzheimer's disease.
		362-06-012. Revealing gray and white matter microstructure differences in subjective cognitive decline using NODDI Shuai Lin, jianxiu lian, Wei Wang First Affiliated Hospital of Harbin Medcial University, China Impact: This study uses NODDI to find GM/WM microstructural changes in SCD, for identifying key predictors and further building a high-performance joint model. It may aid early AD detection and offer an objective imaging tool for SCD diagnosis.
		362-06-013. Sub-voxel quantitative susceptibility mapping of hippocampal subfields in Alzheimer’s disease and mild cognitive impairment Nengjin Zhu, Wenyu Zhou, Zihuan Huang, Haishan Qiu, Hao dong Qin, Hongjiang Wei, Jianping Chu The First Affiliated Hospital, Sun Yat-sen University, China Impact: The current findings allow us to distinguish the opposite susceptibility changes of hippocampal subfields and deepen our understanding of the pathology of the hippocampus in Alzheimer's disease (AD) and mild cognitive impairment (MCI).
		362-06-014. Ventricular Enlargement is the Key Driver of Caudate Displacement in Aging and Vascular Pathologies Archita Khatua, Rittika Dutta, ISHIT SAHOO, Neha Yadav, Niraj Gupta, Vivek Tiwari Indian Institute of Science Education and Research (IISER) Berhampur, Odisha, India Impact: Early signs of vascular stress appear in small periventricular areas like the caudate and nearby white matter. Ratios such as FH/IT, FH/CC, and CC/IT reveal these changes, allowing accurate identification of subcortical remodeling and vascular alterations linked to aging.
		362-06-015. CSF flow dynamics throughout the ventricular system in preclinical Alzheimer’s disease using 4D flow MRI Tomas Vikner, Kevin Johnson, Rachael Wilson, Tobey Betthauser, Victoria Williams, Henrik Zetterberg, Sanjay Asthana, Sterling Johnson, Leonardo Rivera-Rivera University of Wisconsin - Madison, Madison, United States of America Impact: 4D flow MRI showed regional differences in CSF flow dynamics between amyloid-beta (Aβ) positive (N=42) and negative (N=89) cognitively unimpaired individuals, suggesting that altered CSF flow dynamics could be implicated in preclinical Alzheimer’s disease, potentially reflecting impaired CSF-mediated waste clearance.
		362-06-016. Quantitative Assessment of CSF-Vascular Coupling in Alzheimer’s Disease Using Phase-Contrast and 4D-Flow MRI Mengying Lu, Jialu Zhang, Yushan Zheng, Dingtai Wei Fujian Medical University, Fuzhou, China Impact: PC-MRI and 4D-Flow reveal altered CSF-vascular coupling in Alzheimer’s disease, reflecting glymphatic impairment and offering a non-invasive, quantitative method for early diagnosis and disease monitoring.