MRI and MRS in Muscle in Health and Disease
Digital Poster
Musculoskeletal
Tuesday, 12 May 2026
Muscle MRI and MRS in both healthy and diseased populations
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469-04-001.
Condition-Specific Patterns of Muscle Health in Chronic Pain: A UK Biobank Normative Modeling Study
Impact: Leveraging UKBiobank, automated muscle mapping, and normative modeling, we demonstrate localized changes in muscle health for different chronic pain conditions. By enabling inference at the individual level, this approach may be used to guide clinical decision-making and advance precision medicine.
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469-04-002.
Study on the fat infiltration and inflammation changes of paraspinal muscle in patients with CLBP based on Multimodal MRI
Impact: Our study establishes a robust MRI-histopathology correlation in CLBP paraspinal muscles and identifies key molecular alterations, supporting MRI as a non-invasive tool for monitoring muscle degeneration and guiding targeted rehabilitation.
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469-04-003.
Paraspinal muscle degeneration measured by IDEAL-IQ MRI correlates with sagittal imbalance in lumbar disc herniation
Impact: Quantitative IDEAL-IQ links paraspinal muscle degeneration to sagittal imbalance, enabling objective patient stratification for targeted multifidus-focused rehabilitation and sagittal correction. This approach may improve symptoms, reduce progression, and inform prospective trials of biomechanics-guided therapy in diverse clinical populations and implementation.
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469-04-004.
A clinical-radiomics nomogram based on multiparametric MRI to identify muscular dystrophies and non-muscular dystrophies
Impact: For muscle weakness, various myopathy causes (e.g., muscular dystrophies, inflammatory myopathies) should be considered. The treatment of muscular dystrophies differs from that of other myopathies, so differentiating them from other suspected myopathies is clinically important.
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469-04-005.
Associations between MRI and CT measures of skeletal muscle composition and muscle strength in a healthy ageing cohort
Impact: We demonstrate that MRI and CT measures of skeletal
muscle quality have utility for characterising age-related changes in muscle
strength, with MRI measures of muscle contractile volume and fat
deposition showing the most promise for interventional trials in ageing.
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469-04-006.
Strength Assessment of the Vastus Lateralis in Aging Healthy Population Using Statistical Shape Modeling
Impact: Shape modeling enhanced the prediction of muscle strength compared to conventional MRI metrics. This accessible approach, which is externally validated, provides opportunities for the development of image-based biomarkers for early detection of muscular disorders like sarcopenia.
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469-04-007.
Longitudinal Changes in Myosteatosis and Cross-Sectional Muscle Area Following Bariatric Surgery
Impact: Bariatric surgery induces muscle quality changes through reductions in muscle fat content and area, with greater structural changes in patients achieving substantial weight loss. These findings emphasize monitoring muscle quality to improve understanding and implications of myosteatosis in bariatric surgery.
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469-04-008.
A Novel Dynamic 31P MRS Method for Assessment of pH-Resolved ATP Synthesis in Exercising Skeletal Muscle at 7T
Impact:
This Pi-based dynamic 31P MRS technique enables efficient, pH-resolved quantification of ATP synthesis from a single dynamic ³¹P MRS acquisition, providing fiber-type–related physiological insight and advancing evaluation of mitochondrial function in disorders characterized by acidosis or impaired energy metabolism. |
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469-04-009.
Assessing feasibility of mapping skeletal muscle mitochondrial oxidative phosphorylation in upper limbs
Impact: OXCEST MRI enables noninvasive, muscle-specific evaluation of mitochondrial
oxidative phosphorylation in the upper limb. This approach expands metabolic
imaging to mobility-restricted populations, offering a clinically practical
framework to monitor mitochondrial function and therapeutic response in
neuromuscular and metabolic disorders.
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469-04-010.
Test-retest reliability of 13C-MRS with an adiabatic excitation pulse to quantify glycogen in human muscle and liver at 7T
Impact:
13C-MRS at 7T with an adiabatic excitation pulse provides a reliable and reproducible measure of muscle and liver glycogen concentrations, which is promising for its applications to monitor tissue glycogen changes due to intervention/disease progression within the same individuals. |
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469-04-011.
CEST-MRI (3.0T, 9.4T) Evaluation of the Role of Creatine Metabolism in Skeletal Muscle Dysfunction in Knee Osteoarthritis.
Impact: Thigh muscles FF correlates significantly with KOA severity, potentially as an imaging biomarker for progression. Abnormal creatine metabolism may associate with advanced KOA, but 3.0T CEST-MRI sensitivity for early changes is limited, necessitating higher-field validation (9.4T CEST-MRI) .
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469-04-012.
T2 Mapping of Masseter and Temporalis Muscles in Myofascial Pain Syndrome
Impact: Quantitative T₂ mapping of masseter and temporalis muscles
may serve as a non-invasive biomarker for MMPS. Observed T₂ shortening, rather
than the expected prolongation due to inflammation, points to other
microstructural changes in symptomatic muscles that could underlie pain.
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469-04-013.
MR Elastography-Based Slip Interface Imaging of Myofascial Mobility in Chronic Low Back Pain With/Without Fibromyalgia
Impact: This study highlights the potential of Slip Interface
Imaging as an objective biomarker for identifying chronic low back pain (CLBP) patients
with possible myofascial restriction, particularly those with fibromyalgia,
supporting efficient diagnosis, mechanistic classification, and targeted
interventions for CLBP management.
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