Clinical Diffusion Neuro
Digital Poster
Diffusion
Monday, 11 May 2026
This session examines diffusion MRI methods and applications centered on diffusion-weighted imaging and tensor-based techniques (DWI/DTI/DKI), with emphasis on microstructural characterization across neurological and systemic diseases. Presentations address diffusion tensor and kurtosis imaging, tractography-based analyses, and emerging diffusion visualization strategies, alongside longitudinal MRI frameworks supported by robust image registration. Clinical applications span multiple sclerosis, Alzheimer’s disease, traumatic brain injury, severe obstructive sleep apnea syndrome (OSAS), and IDH-mutant brain tumors. Special focus is given to diffusion-derived biomarkers such as the DTI-ALPS index and choroid plexus volume as indicators of microstructural change and fluid-related pathways. By integrating diffusion modeling, tensor imaging, and longitudinal analysis, the session highlights how diffusion MRI can reveal disease-specific trajectories and mechanisms relevant to clinical research and practice.
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362-02-001.
Reversible White Matter Microstructural Changes in Hyperthyroidism: A Diffusion Kurtosis Imaging
Impact: This study highlights reversible white matter microstructural alterations in hyperthyroidism detected using DKI, linking thyroid dysfunction to cognitive deficits and demonstrating thyroxine therapy’s potential to normalize brain microstructure following restoration to the euthyroid state.
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362-02-002.
Probiotics Alters Brain Structure and Function in IBS: A Randomized Controlled Trial
Impact: This study provided novel in-vivo neuroimaging evidence that probiotics modulate central pathways in IBS, bridging the gap between probiotics modulation and brain function, with implications for developing targeted brain-gut axis therapies.
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362-02-003.
Time-Dependent Diffusion MRI–Based Microstructural Mapping for Predicting IDH Mutation Status in Glioma: A Multicenter Study
Impact: This study evaluated the clinical utility of td-dMRI–derived histogram features for predicting IDH mutation status. Key findings revealed significant differences in microstructural features between IDH–mutant and IDH–wildtype gliomas, supporting their potential as noninvasive imaging biomarkers for IDH identification.
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362-02-004.
Histogram analysis of QSM and DKI for identifying molecular subtypes of adult diffuse gliomas
Impact: Noninvasive QSM and DKI histogram analysis enables early molecular profiling of gliomas, supporting individualized therapy decisions and improving prognostic evaluation for patients.
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362-02-005.
Assessment of Voxelwise Longitudinal Changes in Tissue Microstructure Measured with MAP-MRI following mTBI
Impact: Longitudinal monitoring of within-subject MAP-MRI
changes may provide a more comprehensive means to study pathological
alterations that evolve at multiple timepoints following mTBI, where current cross-sectional
studies of image-based biomarkers lack the sensitivity and specificity to
predict outcome.
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362-02-006.
Multimodal MRI Indicators of Mild Cognitive Impairment from the Cleveland Alzheimer’s Disease Research Center (CADRC)
Impact: The large effect sizes suggest that multimodal MRI has potential
to serve as a biomarker for evaluating therapies before symptom onset in AD.
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362-02-007.
Mapping Neuropsychological Correlations to White Matter Organization in Individuals with and without Freezing of Gait in PD
Impact: This study demonstrates that improving sensitivity to crossing-fiber regions through fixel-based diffusion MRI uniquely captures white matter relationships with neuropsychological measures, distinguishing PD freezers from non-freezers.
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362-02-008.
Enhanced Characterization of MS Normal-Appearing White Matter: Evaluating Diffusion Complexity as a Complementary Tool to DTI
Impact: Diffusion Complexity (DC) reveals early microstructural damage in MS normal-appearing white matter, invisible to conventional DTI. This provides a new, non-redundant biomarker to monitor "hidden" disease progression and assess tissue integrity.
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362-02-009.
Glymphatic dysfunction and white-matter disruption: MRI study of chain mediation linking hydrocephalus to cognitive decline
Impact: Our results showed glymphatic dysfunction and white-matter disruption sequentially mediate the association between ventricular dilation and cognitive decline in hydrocephalus. Our study might provide insights for facilitate early intervention and rehabilitation of cognitive decline for hydrocephalus patients.
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362-02-010.
Microstructural imaging of Glioblastoma tumours using ultra-strong gradient and multi-dimensional diffusion MRI
Impact: We show first multidimensional
ultra-high diffusion-weighted MRI data to characterize glioblastoma tumour
microenvironment with unprecedented specificity. This non-invasive approach
offers new opportunities to improve diagnosis, refine surgical margins, and
track tumour response to therapy without the need for repeat biopsies.
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362-02-011.
Moderating Role of Age in the Relationship Between Immunomodulatory Factor and Brain structure in Autism Spectrum Disorder
Impact: This study aimed to investigate the effects
of immunomodulatory factors on brain structure in children with autism spectrum
disorder (ASD) and to explore whether these effects are moderated by age,
thereby providing new insights into the biological mechanisms of ASD.
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362-02-012.
Individualized white matter mapping in pediatric drug-resistant temporal lobe epilepsy using one-vs-many diffusion MRI
Impact: Individual-level diffusion MRI mapping of white matter microstructure in children with drug-resistant temporal lobe epilepsy reveals patient-specific abnormalities hidden by group analyses. With further work, these findings could inform preoperative evaluation and complement other clinical data to support surgical planning.
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362-02-013.
Inter-scanner harmonisation of the PREDICTOM MRI protocol
Impact: The EU-funded PREDICTOM project searches for early
MRI-biomarkers for Alzheimer’s disease. The project will use scanners of
different vendors and types, necessitating harmonisation. Scans on a volunteer
in a single site using two vendors show reproducible quantitative
MRI-parameters after harmonisation.
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