MRI Markers of Dementia
Digital Poster
Neuro A
Wednesday, 13 May 2026
Various types of changes occurring in dementia, predominantly not related to AD.
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566-02-001.
Image quality assessment of a comprehensive ultra-fast MRI protocol for dementia diagnosis and monitoring
Impact: While clinically non-inferior for diagnosis, quantitative image quality reductions in ultra-fast protocols necessitate further validation for research applications and development of acceleration-aware post-processing. This characterisation informs protocol selection and identifies specific targets for post-processing optimization in accelerated dementia MRI.
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566-02-002.
Quantitative Susceptibility Mapping Reveals Brainstem Iron Changes in Dementia with Lewy bodies
Impact: This work highlights QSM’s potential as a sensitive in
vivo biomarker for detecting region-specific iron-related neurodegeneration in Dementia
with Lewy bodies, bridging brainstem pathology with clinical manifestations and
paving the way for earlier diagnosis and targeted therapeutic interventions.
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566-02-003.
Quantitative and Visual FDG-PET/MRI Integration for Differentiating Major Dementia Syndromes
Impact: By applying identical regional frameworks to visual and
quantitative analyses, this study reveals their complementary diagnostic
contributions. Visual reading captures clinical patterns, while quantitative
metrics add objectivity and reproducibility, together enhancing multimodal PET
and structural MRI interpretation in dementia.
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566-02-004.
Impact of Cardiovascular-Kidney-Metabolic Syndrome on Dementia Subtypes and Brain Volume Changes
Impact: Brain MRI revealed stage-dependent brain atrophy and increased white matter hyperintensities in cardiovascular-kidney-metabolic syndrome, paralleling dementia risk. These imaging biomarkers provide mechanistic insight and potential early indicators for targeted prevention in individuals with progressive metabolic-vascular disease.
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566-02-005.
Selective Thalamic Atrophy Linked to White Matter Hyperintensities and β-Amyloid in Cerebral Small Vessel Disease
Impact: This study identifies distinct thalamic subregional atrophy driven by strategic white matter hyperintensities and β-amyloid burden in cerebral small vessel disease, highlighting new imaging biomarkers and potential intervention targets for preventing cognitive decline in vascular and mixed dementias.
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566-02-006.
Diffusion-Based Inpainting Enables Reliable Detection of New Cerebral Microbleeds Without Longitudinal MRI Data
Impact: Our diffusion-model based approach enables more reliable detection
of new cerebral microbleeds, supporting clinical decision-making in
neurodegeneration and therapy safety, even when longitudinal imaging data are
limited.
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566-02-007.
Diverse impact of intensity normalization techniques on white matter hyperintensity quantification
Impact: We demonstrate that intensity normalization methods (specifically, WhiteStripe and Z-Score) can significantly alter white matter hyperintensity (WMH) volumes, suggesting alternative techniques will better preserve pathology and support robust conclusions across multi-site, paired multi-field strength, and between-group studies.
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566-02-008.
FLAIR-less white-matter hyperintensity segmentation using YODA
Impact: YODA enables generation of 1.0 and 0.8 mm synthetic FLAIR images from routinely acquired MRI contrasts and thus enables accurate population-based white-matter hyperintensity (WMH) quantification. Yet, we demonstrate that FLAIR is crucial in detecting and differentiating small, individual WMHs.
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566-02-009.
Enhancing Diagnosis of FTD and AD: The Impact of Population-Specific Brain Norms and Automated ACE Score Prediction
Impact: Our study shows that Indian norms
improved diagnostic sensitivity, emphasizing the need for population-specific
references. Automated ACE score prediction demonstrated that regional brain
atrophy strongly correlated with cognitive decline, enabling more accurate
cognitive and structural assessment in diverse cohorts.
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566-02-010.
QQ-based oxygen extraction fraction (OEF) mapping in dementia mouse brain
Impact: This
is the first application of
QQ-based OEF method in a mouse neurological
disorder model. Observed higher OEF in
dementia mice versus controls demonstrates QQ’s potential in preclinical research, enabling investigation
of abnormal cerebral
oxygen metabolism across various
pathological conditions.
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566-02-011.
NODDI, Diffusion Tensor Microstructural Abnormalities and Gray Matter Atrophy Contribute to Cognitive Impairment in RRMS
Impact: A disconnection syndrome caused by the accumulation of microstructural tissue abnormalities in cognitively-related white matter (WM) tracts may contribute to cognitive deficits.
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566-02-012.
Topography of Juxtaventricular WMHs and Cognitive Associations in Alzheimer’s Disease: a Dual-Cohort Study
Impact: JVWMH provides diagnostic and prognostic information beyond conventional WMHs measures in AD. The JVWMH-CSFV correlation is consistent with CSF–parenchyma interface processes.
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566-02-013.
Cognitive Decline in Parkinson's Disease: Correlation with Choroid Plexus Volume
Impact:
In Parkinson's disease cohort, choroid plexus enlargement was associated with reduced cognitive performance, and with progression into dementia and brain atrophy. These findings support the hypothesis that choroid plexus alterations might reflect neuroinflammatory or barrier dysfunction processes impacting cognition. |
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566-02-014.
Oral microbiota dysbiosis related to the cortical thinning and cognition in cerebral small vessel disease
Impact: This study revealed the impacts of oral microbiota dysbiosis on the
progress of cortical thinning in CSVD, and suggested the mediative role of cortical
thickness in linking oral microbes to cognition, providing insights
for the potential mechanisms of oral-brain axis.
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