Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Spectroscopy and Spectroscopic Imaging: Neuro II

Spectroscopy and Spectroscopic Imaging: Neuro II

Digital Poster

Neuro B

Monday, 11 May 2026

Digital Posters Row C

16:10 - 17:05

Session Number: 362-05

No CME/CE Credit

Similar Sessions

This session focuses on proton and non-proton MR spectroscopy applications in the healthy brain and various neurological disorders

		362-05-001. Acute neurometabolic responses in human brain following a single bout of vigorous exercise: a dynamic 1H-MRS/I study Jedd Pratt, Antonia Kaiser, Libby Henthorn, Oliver Mundell, Elise From, Aneurin Kennerley, Craig Sale Manchester Metropolitan University, Manchester, United Kingdom Impact: This study suggests that vigorous exercise dynamically alters brain energy metabolism and neurotransmission, highlighting increased reliance upon creatine and lactate as energy substrates. Acute neurometabolic shifts may underlie exercise-related benefits to cognitive function and represent a target for neuroprotective interventions.
		362-05-002. Preliminary ¹H-MRS Study of the Glia–Energy Metabolic Axis After Shunting and Prognosis in iNPH Yunjung Bae, Hyeong Hun Lee, So Young Ji Seoul National University Bundang Hospital, Seoul, Korea, Republic of Impact: Despite the limited sample size, convergent patterns—CSF-driven inositol dynamics, ACC–CSO lactate coupling, and small yet consistent prognostic signals—suggest that 1H-MRS may assist biological stratification and prognosis of shunt response in iNPH, encouraging early-phase, standardized, multi-site studies.
		362-05-003. T1 relaxation times of 31P in human calf muscle at 5T: A comparison between endurance-trained and normally active individuals Yiling Liu, Xingfeng Shao, Yanxing Yang, Shuheng Zhang, Jiawen Sun, Naying He, Fuhua Yan Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Impact: Using ³¹P MRS at 5T, this study investigated differences in T1 relaxation times and exercise responses in calf muscle between long-term trained and normally active individuals, and demonstrated a significant decrease (10.5%) in Pi T1 value in long-term trained volunteers.
		362-05-004. Cystathionine-Targeted MRS Study: Cystathionine as an Imaging Biomarker for IDH-Mutant Gliomas With 1p/19q Codeletion Xiaozhu Hao, Siyuan Fang, Yefeng Yao, Zhenwei Yao Huashan Hospital, Fudan University, China Impact: Cystathionine-targeted MRS enables precise preoperative diagnosis and metabolic characterization of IDH-mutant gliomas with 1p/19q codeletion. The brief scan time and user-friendly post-processing software could enhance clinical feasibility and promote widespread adoption.
		362-05-005. Neurochemical and Transcriptomic Bases of Cortical Network Vulnerability in Parkinson’s Disease with Probable RBD Pengfei Zhang, Kuanrong Jian, Xinyue Wan, Qiyong Gong Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China Impact: This study identifies probable REM sleep behavior disorder as a distinct PD phenotype characterized by convergent structural, neurochemical, and molecular vulnerabilities, offering mechanistic insight into disease progression and enabling biomarker-driven patient stratification and targeted therapeutic strategies.
		362-05-006. Metabolite changes in the SOD1 transgenic mouse model of ALS using magnetic resonance spectroscopy Colleen Bailey, Hussein Ghazale, EunJee Park, Carol Schuurmans, Jamie Near Sunnybrook Research Institute, Toronto, Canada Impact: The SOD1 gene is the most common mutation site in familial ALS. The NAA findings in mice differ from human studies, potentially because of low MRS sensitivity, but important changes related to energy metabolism, antioxidants and glutamate pathways are detectable.
		362-05-007. Highly Localised Frontal Lobe Phosphorous MR Spectroscopy at 7 Tesla using a Dual-Tuned 1H/31P Surface Coil Un Hou Chan, Jabrane Karkouri, Antoine Naegel, Marzena Wylezinska-Arridge, David Leitão, Sarah McElroy, Thomas Eykyn, Chris Rodgers, Alice Egerton, Vicky Goh, Ozlem Ipek King's College London, London, United Kingdom Impact: A dual-tuned ¹H/³¹P surface coil delivered high-SNR frontal spectra at 7T while keeping SAR manageable, paving the way for reliable metabolic measurements in prefrontal cortex for studies of mitochondrial function, membrane turnover, and disease progression monitoring.
		362-05-008. Deep Phenotyping reflects multivariate association between sleep metrics and Glutamate - A 7T longitudinal investigation Joshita Majumdar, Lavanya Sankaran, Nguyen Huynh, Adil Bashir, Gopikrishna Deshpande Auburn University Neuroimaging Center, Auburn University, Auburn, United States of America Impact: Leveraging the enhanced spectral precision of ultra-high-field 7T MRS for characterizing glutamate, this study provides insights into the neurochemical basis of sleep in naturalistic settings, potentially advancing the understanding of sleep disorders and guiding improved therapeutic management.
		362-05-009. Metabolic Milestones: Mapping Healthy Aging with ³¹P Spectroscopy Zoona Javed, Guilhem Collier, Thomas Payne, Oliver Bandmann, Rolf Schulte, Nigel Hoggard, Jim Wild The University of Sheffield, Sheffield, United Kingdom Impact: This study demonstrates that ³¹P-spectroscopy metabolites and derived ratios are reliable indicators of brain energy metabolism, showing significant age dependence in both global and regional measures, along with notable differences between male and female ratios across populations.
		362-05-010. Region and Cell-Type Specific Impacts of Subanesthetic Ketamine on Neurometabolic Activity in Mouse Brain Ajay Sarawagi, Sreemantula Arun Kumar, Anant Patel CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India Impact: This study revealed that sub-anesthetic ketamine selectively enhances synaptic activity in the prefrontal cortex in a time-dependent manner, offering new insights into the cell-type and region-specific neurometabolic mechanisms underlying its rapid antidepressant effects and guiding future therapeutic strategies.
		362-05-011. Neurometabolic Trends of Aging in the Mouse Hippocampus Revealed by 1H Magnetic Resonance Spectroscopy Kay Igwe, Adriana King, Zongyu Li, Jia Guo Columbia University, New York, United States of America Impact: Baseline hippocampal metabolite trajectories obtained from 1H MRS in normally aging mice establish essential reference patterns for detecting early, disease-related neurometabolic alterations in models of Alzheimer’s and other neurodegenerative disorders.
		362-05-012. In vivo Detection of α-Glucose and Lactate in Cerebrospinal Fluid Using a Novel J-Edited MRS Sequence Tao Gong, Jiaxiang xin, WEI ZHAO, guangbin wang Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, China Impact: This study demonstrates a flexible ¹H MRS protocol enabling selective in vivo detection of α-Glc and Lac in CSF, providing a potential noninvasive biomarker for early diagnosis and longitudinal monitoring of Metabolic and neurodegenerative diseases.
		362-05-013. Identification of Downfield Resonances in Human Brain Using 3T MRS:Comparison of Metabolite-Cycling and Narrowband Excitation Ajin Joy, Andres Saucedo, Paul Macey, Karin Nielsen-Saines, Rajakumar Nagarajan, uzay emir, Arun Karlamangla, Ebrahim Haroon, Michael Thomas David Geffen School of Medicine at University of California, Los Angeles, United States of America Impact: This study demonstrates that both metabolite-cycling and narrowband excitation techniques successfully detect downfield NAD⁺, tryptophan, and amide resonances, enabling translation of downfield MRS at 3T.
		362-05-014. Tracking Neuro-muscular Metabolism with Magnetisation Transfer-based localised 31P ISIS at 3T Isaac Watson, Elisa Zamboni, Jedd Pratt, Fabio Zambolin, Jamie McPhee, Aneurin Kennerley University of Leeds, Leeds, United Kingdom Impact: This study demonstrates that MT-ISIS ³¹P-MRS enables precise, non-invasive assessment of neuromuscular energy metabolism. Detecting reduced ATP synthesis following exercise-induced muscle damage, advances our understanding of metabolic dysfunction in muscle injury and neuromuscular disorders, informing future diagnostic and therapeutic strategies.
		362-05-015. Characterization of metabolic profiles of low- and high-grade gliomas by 1H FID MRSI at 7T Mahrshi Jani, Kimberly Chan, Andrew Wright, Yeison Rodriguez, Shengyue Su, Anke Henning University of Texas Southwestern Medical Center, Dallas, United States of America Impact: This study examines correlations between proton MRSI-derived metabolite concentrations in glioblastoma using ultra-high-field MRI/MRSI. Such relationships are difficult to assess at clinical field strengths, and their characterization may enhance understanding of tumor metabolism and improve glioblastoma biomarker development.