Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - The Dynamic Brain: Flow, Pressure, and Exchange

The Dynamic Brain: Flow, Pressure, and Exchange

Oral

Neuro A

Tuesday, 12 May 2026

Auditorium 2

13:40 - 15:30

Moderators: Joel Stein & Xingfeng Shao

Session Number: 406-02

CME/CE Credit Available

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This session highlights cutting-edge MRI approaches to probe cerebral fluid, vascular, and tissue dynamics, with a focus on low-frequency oscillations, perivascular spaces, arterial and venous flow, and tissue mechanics. Together, the talks reveal how pressure, flow, and hemodynamic drivers interact across compartments of the human brain, enabled by advanced motion-robust, multimodal, and ultra–high-field imaging techniques.

Skill Level: Basic,Intermediate,Advanced

13:40		406-02-001. Simultaneous assessment of cardiac-driven cerebral arterial, venous, CSF dynamics and coupling with multiband dualVENC PC-MRI Jianing Tang, Tianrui Zhao, Sang Hun Chung, Lirong Yan Northwestern University, Chicago, United States of America Impact: MB-DV PC-MRI enables simultaneous assessment of CSF, arterial, and venous dynamics and coupling. This technique holds promise for advancing our understanding of blood-neurofluid coupling, with potential applications in studying neurovascular and neurodegenerative diseases.
13:51		406-02-002. Diffusion Tensor Imaging Along Perivascular Spaces (DTI-ALPS): a meta-analysis Sanne Schriemer, Anders Wåhlin, Sara Qvarlander, Ingrid Mossige, Anders Eklund, Lydiane Hirschler, Erik van Zwet, Rolf Fronczek, Geir Ringstad, Matthias van Osch Leiden University Medical Center, Leiden, Netherlands Impact: An evaluation of the Diffusion Tensor Imaging ALong Perivascular Spaces (DTI-ALPS) method is crucial to clarify what it truly measures, preventing its premature use as a glymphatic biomarker and avoiding disease misclassification or misjudged treatment effects.
14:02		406-02-003. Rapid Tissue-CSF Exchange in the Perivascular Space Detected by Magnetization Transfer Indirect Spin Labeling Yihan Wu, Kexin Wang, Licheng Ju, Anna Li, Qin Qin, Feng Xu, Doris Lin, Lawrence Kleinberg, Jiadi Xu Johns Hopkins University, Baltimore, United States of America Impact: MISL enables non-invasive mapping of tissue-CSF water exchange with high sensitivity and spatial resolution. By capturing perivascular and age-related dynamics, it enables functional assessment of glymphatic exchange and offers a promising biomarker for detecting early CSF dysfunction and physiological alterations.
14:13		406-02-004. Distinct pressure- and flow-driven propagation pathways of low-frequency oscillations in the human brain Adam Wright, Vidhya Nair, Brianna Kish, Varan Sriram, Qiuting Wen, Yunjie Tong Purdue University, West Lafayette, United States of America Impact: This work identifies two distinct mechanisms by which low-frequency oscillations propagate through the brain: pressure- and flow-driven pathways. Characterizing these transmission modes advances their application in key domains: probing brain fluid dynamics and serving as endogenous markers of cerebrovascular health.
14:24		406-02-005. Brain-wide mapping of perivascular networks with 14 Tesla MRI Xiaoqing Zhou, Xiaochen Liu, Sangcheon Choi, Weitao Man, David Hike, Nivetha Pasupathy, Yuanyuan Jiang, Xin Yu Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America Impact: This study establishes a comprehensive 14 T MRI framework for visualizing perivascular spaces across brain regions, revealing hierarchical pathways from surface arteries to hippocampal vessels and advancing understanding of brain-wide glymphatic circulation and its dysfunction in neurological disorders.
14:35		406-02-006. Distinct Hydrodynamic and Hemodynamic Drivers in the Brain Parenchyma Revealed by Multi-modal Dynamic MRI Jianing Zhang, Adam Wright, Elodie Foster, Qiuting Wen Indiana University School of Medicine, Indianapolis, United States of America Impact: This study reveals respiration-driven hydrodynamics and LFOs-dominant hemodynamics within the brain parenchyma, suggesting a more complex fluid regulation than in the subarachnoid space. These findings underscore the importance of concurrently assessing both fluid compartments to better understand cerebral clearance physiology.
14:46		406-02-007. High-Resolution Intrinsic MRE of the Human Brain on the NexGen7T with an Anisotropic, Viscoelastic Tissue Model Kulam Najmudeen Magdoom, Oleksandr Khegai, Erica Walker, Alexander Beckett, Alexandru Avram, David Feinberg, An Vu, Peter Basser The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, United States of America Impact: We have developed a method to obtain high-resolution elastograms of human brain tissue without a tamper. The results indicate new contrasts compared to DTI and identifies mechanical interfaces which may be vulnerable to injuries, such as in TBI.
14:57		406-02-008. Insulin signaling and aquaporin 4 interactions regulate cerebrospinal fluid dynamics in the optic nerve Muneeb Faiq, Thajunnisa Sajitha, Carlos Parra, Anoop Sainulabdeen, Choong Lee, Jiangyang Zhang, Gadi Wollstein, Joel Schuman, Kevin Chan Stanford Medicine, Stanford, United States of America Impact: Central insulin resistance mimics aquaporin 4 (AQP4) suppression in disrupting optic nerve cerebrospinal fluid dynamics, whereas AQP4 enhancement restores it, supporting an insulin–AQP4–glymphatic axis and identifying a potential target for metabolic neurovascular dysfunction.
15:08		406-02-009. Intrinsic CSF Outflow: MRI evidence for Distinct Flow Mechanisms Vadim Malis, Mitsue MIYAZAKI University of California, San Diego, United States of America Impact: A bi-component model combining Gaussian and Γ-variate terms provides a physiologically interpretable framework for quantifying fast and slow CSF outflow from non-contrast Time-SLIP MRI, enhancing accuracy and enabling future assessment of disease- or age-related alterations in glymphatic clearance.
15:19		406-02-010. Comparing the measures of Glymphatic Index derived using Magnetic Resonance Encephalography (MREG) and DTI-ALPS. Surya Sai Maheswar Budidi, Rodolphe Nenert, Amy Amara, Jerzy Szaflarski, Virendra Mishra University of Alabama at Birmingham, Birmingham, United States of America Impact: The findings indicate that MREG may be a more sensitive means of evaluating glymphatic activity compared to DTI-ALPS, offering new opportunities to understand the role of sleep in the brain clearance mechanism.