Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

Cardiovascular and Body Imaging

Oral

Preclinical

Tuesday, 12 May 2026

Meeting Room 2.60

16:00 - 17:50

Moderators: Anant Patel & Ulrich Flögel

Session Number: 430-04

CME/CE Credit Available

Similar Sessions

Preclinical MRI of myocardium, cardiac function, hepatic, renal, gastrointestinal, and skin imaging.

16:00		430-04-001. Lipomatous Metaplasia in Hemorrhagic and Nonhemorrhagic Myocardial Infarctions: A PET/MRI Study with Histological Validation Joao Pedro Torres Neiva Rodrigues, Leon Riehakainen, Alan Kwan, Debiao Li, Ivan Cokic Cedars-Sinai Medical Center, Los Angeles, United States of America Impact: Demonstrating the presence of adipose cells in nonhemorrhagic myocardial infarctions challenges the paradigm that iron is the key driver of lipomatous metaplasia in infarcted myocardium.
16:11		430-04-002. Multi-parametric CMR and Multi-scale Histological Evaluation of Myocardial Remodeling in Myocarditis Mice Qinfang Miao, Wenjing Zhao, Ke Yang, Hongzhang Huang, Zhenfeng Lyu, Rui Luo, Yujie Chen, Zhaoying Wen, Haikun Qi ShanghaiTech University, Shanghai, China Impact: By integrating multi-parametric cardiac magnetic resonance (CMR) with multi-scale histological analysis, this study comprehensively validates the sensitivity of CMR biomarkers to dynamic inflammatory and fibrotic changes, providing a solid pathological foundation for noninvasive diagnosis and precise monitoring of myocarditis progression.
16:22		430-04-003. Monitor metabolic changes in High-Altitude Acute Myocardial Injury using hyperpolarized ¹³C MRS Xiyuan Zhong, Changwei He, Minjie Zhu, XiaoFang Yang, Yunxi Lv, Jinxia Guo, Min Wu Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China Impact: Hyperpolarized ¹³C MRS detected metabolic alterations in the rat heart following acute high-altitude exposure. These findings underscore the value of hyperpolarized ¹³C MRS for in vivo characterization of cardiac metabolism and its potential utility in the diagnosis of related disease.
16:33		430-04-004. Targeted 19F MRI Reveals Neutrophil-driven Inflammation in Takotsubo Syndrome Ulrich Flögel, Katharina Kurz, Pascal Bouvain, Patricia Kleimann, Elias Rawish, Thomas Stiermaier Experimental Cardiovascular Imaging, Heinrich Heine University, Düsseldorf, Germany Impact: This study demonstrates that targeted ¹⁹F MRI can sensitively detect early neutrophil infiltration in Takotsubo syndrome (TTS), revealing inflammation as a key driver of cardiac dysfunction. These findings identify neutrophil-driven inflammation as a promising therapeutic and diagnostic target for TTS.
16:44		430-04-005. In vivo evaluation of hepatic glutathione dynamics following pharmacological inhibition using 11.7 T ¹H MRS NITTA NOBUHIRO, Yuji Komaki, Suemizu Hiroshi, Yoneda Nao, Uehara Shotaro, Suematsu Makoto Central Institute for Experimental Medicine and Life Science, Tokyo, Japan Impact: This study establishes ultra-high-field ¹H MRS as a noninvasive tool for monitoring hepatic metabolic dynamics, enabling real-time assessment of drug-induced metabolic alterations and providing a foundation for future studies on liver function and therapeutic response.
16:55		430-04-006. Dynamic mapping of Glc oxidative metabolism in young rats with chronic liver disease using 1H-2H-FID-MRSI at 9.4T Gianna Nossa, Alessio Siviglia, Dario Sessa, Estelle Gerossier, jocelyn Grosse, Cristina Cudalbu, Bernard Lanz CIBM Pre-Clinical Imaging EPFL, Lausanne, Switzerland Impact: Our pilot study demonstrated the first application of an indirect deuterium ¹H-[²H]-FID-MRSI detection methodology on chronic liver disease rats with strong reproducibility, paving the way for extended longitudinal studies on glucose oxidative metabolism in disease models.
17:06		430-04-007. Multiparametric MRI Assessment of Long-Term Hepato-Renal Remodeling in MASLD following Unilateral Renal Ischemia-Reperfusion Chao Wang, Shuangshuang Xie, Xiaoguang Yang, Haina Li, Kang Simeng, Shen Wen Hohhot First Hospital, Hohhot, China Impact: Zone-specific, noninvasive MRI biomarkers quantify hepato-renal remodeling and reveal that MASLD timing modulates renal repair. These metrics enable early stratification and longitudinal monitoring, guide endpoint selection for trials, and motivate studies of metabolic interventions and timing to prevent AKI-to-CKD progression.
17:17		430-04-008. From Imaging to Mechanisms: MRI-Based Insights into Diabetic Gastroparesis in Rats Xiaokai Wang, Fatimah Alkaabi, Ashley Cornett, Xiaoyin Wu, Emma Arnhols, Ulrich Scheven, Zhongming Liu University of Michigan, Ann Arbor, United States of America Impact: Our findings provide the first preclinical evidence of using dynamic MRI to characterize gastric functional deficits and associate them with the underlying cellular-level pathological changes. The study marks a significant step toward MRI-informed personalized diagnosis and management of gastroparesis.
17:28		430-04-009. A modular 19F MRI reporter for Activity-Based Sensing of Analyte-pH Activity Profile Suritra Bandyopadhyay, Jefferson Chan University of Illinois at Urbana-Champaign, Champaign, United States of America Impact: This work introduces ¹⁹F MRI probes that independently report analyte activity and pH, overcoming limitations of optical systems and enabling investigation of disease processes where microenvironmental pH governs biochemical activity, such as inflammation, ischemia–reperfusion injury, and gastrointestinal pathologies.
17:39		430-04-010. Effects of gadolinium deposition on transcriptome levels in skin: a dual model of rats and mice Chuan bing Wang, Shouju Wang the First Affiliated Hospital With Nanjing Medical University (Jiangsu Province Hospital), Nan jing, China Impact: Our study is the first to link dermal gadolinium retention with transcriptomic alterations and behavioral changes, highlighting the potential risks of linear GBCAs. These findings urge further investigation into the molecular mechanisms underlying gadolinium deposition and its clinical implications.