Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

Probes and Targets

Digital Poster

Preclinical

Monday, 11 May 2026

Digital Posters Row G

14:45 - 15:40

Session Number: 366-04

No CME/CE Credit

Similar Sessions

Probes and targets for preclinical molecular imaging, MR contrast mechanisms, and advanced biomarker detection.

		366-04-001. Hyperpolarized ¹³C‑Pyruvate MRI Detects Early Metabolic Transition from Healthy Liver to MASH and to HCC Mohammad Ghaderian, Vera Jörke, Theresa Hune, Oliver Hihn, Anais Choffart, Laimdota Zizmare, Sergey Korchak, Max Zimmermann, Lisa Fries, Gyuantae Bae, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Nicolas Kempf, Kai Buckenmaier, Stefan Glöggler, Johannes Schwenck, Andre Martins Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Germany Impact: This work highlights the potential of non-invasive ¹³C hyperpolarized metabolic imaging for early diagnosis and monitoring of MASH progression to HCC. ¹³C hyperpolarized metabolic imaging provides a sensitive, quantitative tool for monitoring liver disease progression and therapeutic outcomes.
		366-04-002. Hyperpolarized dimethyl [1,4-13C2]fumarate as a probe of gluconeogenesis in the liver and kidney Mai Huynh, Sung-Han Lin, Xiaodong Wen, Zohreh Erfani, Jae Hong Park, Zoltan Kovacs, Craig Malloy University of Texas Southwestern Medical Center, Dallas, United States of America Impact: Dimethyl [1,4-¹³C₂]fumarate is a promising tracer for identifying the primary sources of new glucose production especially in humans, as the significantly lower esterase activity in human blood would allow the esterified form to remain intact longer in circulation.
		366-04-003. A Gadolinium-Based Nanoparticle Targeting Neutrophil Extracellular Traps (NETs) for MRI-Specific Diagnosis of Liver Fibrosis Zonglin Liu, Zhenwei Yao, Pu-Yeh Wu, Shiman Wu Huashan Hospital, Fudan University, China Impact: This NETs-targeted nanoprobe enables noninvasive stratification of liver diseases via MRI, potentially transforming early detection and guiding personalized therapies for patients with fibrosis and HCC.
		366-04-004. High-resolution brain‑wide and single-vessel fMRI mapping using the NOSTIC hemogenetic reporter in mice Yuanyuan Jiang, Yuting Ke, Xiaoqing Zhou, Ying Jiang, David Hike, Nivetha Pasupathy, Xiaochen Liu, Xin Yu, Alan Jasanoff Massachusetts General Hospital and Harvard Medical School, Boston, United States of America Impact: These studies reveal that high-resolution signals and evidence for control of single vessels can be obtained using the NOSTIC reporter in fMRI.
		366-04-005. Cu-MNP-PEGs Enable MRI-Guided Hyperthermia-Enhanced Chemodynamic Therapy against Glioblastoma through Cuproptosis Ying Shi, Wenshuang Wang, Pengfei Liu, jianxiu lian The First Affiliated Hospital of Harbin Medical University, Harbin, China Impact: This study presents biocompatible nanoplatforms capable of enabling MR imaging, high anti-tumor cuproptosis efficacy, and negligible side effects in the treatment of GBM.
		366-04-006. Treatment with NAMPT Activator Enhances Cerebral Glucose Metabolism in AD Mice Sunil Khokhar, Narayan Datt Soni, Anshuman Swain, Abeer Mathur, Paul Jacobs, Dipak Roy, Halvor Juul, Blake Benyard, Dushyant Kumar, RAVI PRAKASH REDDY NANGA, Ravinder Reddy, Mohammad Haris University of Pennsylvania, Philadelphia, United States of America Impact: NAMPT activator treatment rescued glucose metabolism deficits in an Alzheimer's disease mouse model, increasing cerebral glucose metabolism and NAMPT levels. This suggests NAMPT activation as a potential therapeutic strategy for addressing metabolic dysfunction in Alzheimer's disease.
		366-04-007. Evaluation of Manganese Chloride as a Radiation Countermeasure Using an Automated Preclinical MRI Deep Learning Pipeline Nikolai Rakhilin, Alexandru Korotcov, Emma Wallace, Gregory Homes-Hampton, Anwar Ahmed, Barbara Knollmann-Ritschel, Maureen Hood Uniformed Services University of the Health Sciences, Bethesda, United States of America Impact: Development of a rapid, automated AI method to segment 3D organs from preclinical MRI and quantify radiation injury, demonstrating the prophylactic efficacy of MnCl₂ in an Acute Radiation Syndrome mouse model.
		366-04-008. Monitoring of the gastrointestinal tract passage using fluorinated polymer tracers and 19F MRI Vít Herynek, Ondřej Groborz, Margarita Tkachenko, Mária Hovořáková, Filip Koucký, Kristýna Kolouchová, Luděk Šefc First Faculty of Medicine, Charles University, Prague, Czech Republic Impact: We developed a fluorinated polymer tracer for gastrointestinal tract imaging using ¹⁹F MRI, which was successfully tested in animals. The project outlines both possible applications in clinical practice, and direction for synthesis of unconventional tracers for MRI.
		366-04-009. Fluorinated Lipid Nanoparticles Enable Real-Time 19F MRI Tracking and Lymph-Node-Targeted Delivery of mRNA Vaccine Kairu Xie, Lijun Zhu, Yu Li, Yu Fu, Haiqiang Wang, Zhong-Xing Jiang, Daiqin Chen, Xin Zhou Innovation Academy for Precision Measurement Science and Technology,CAS, Wuhan, China Impact: This study introduces an FLNP system integrating nucleic acid delivery with ¹⁹F NMR/MRI monitoring, providing mechanistic insight into how nanocarrier kinetics regulate immune activation and vaccine performance.
		366-04-010. ADAMTS4-Targeted Molecular MR Imaging in a Porcine Model of Abdominal Aortic Aneurysm Marie-Luise H. Ranner-Hafferl, Dilyana Mangarova, Jennifer Heyl, Jennifer Mein, Jana Moeckel, Dirk Schnappauf, Timo Auer, Federico Collettini, Lisa Adams, David Ahlers, Marcus Makowski, Uwe Karst, Bernd Hamm, Julia Brangsch, Avan Kader Charité – Universitätsmedizin Berlin, Berlin, Germany Impact: ADAMTS4-targeted molecular MRI enables early detection of active ECM degradation in AAA, providing biological insight beyond anatomicalmeasurements. This approach could improve understanding of aneurysm pathophysiology, guide therapeutic monitoring of ECM-stabilizing treatments, andcomplement size-based surveillance strategies.
		366-04-011. Therapeutic Study of Liver Cirrhosis Using NaGdF4@ZIF-8-Labeled BMSCs with MR Monitoring Yuxin Huang, Shiman Wu, Pu-Yeh Wu, Ying Chen, Zonglin Liu Huashan Hospital, Fudan University, China Impact: NaGdF₄@ZIF-8 exhibits high T1 relaxivity, excellent ROS scavenging ability, and good biocompatibility, making it a valuable tool for assisting stem cell therapy in liver cirrhosis and monitoring the short-term colonization of stem cells after injection.
		366-04-012. Dynamic Nitroxide-enhanced MRI with Independent Measurement of REDOX and ROS Ralph Hurd, Abbas Khojasteh, Meng Gu, Laura Pisani, Niven Narain, Lawrence Recht, Daniel Spielman Stanford Medicine, Stanford, United States of America Impact: Independently extracting reductive capacity and ROS from dynamic nitroxide-enhanced MRI adds specificity in the study of tumor progression and response to therapy. The method introduced provides an additional metric for dose adjustment and new tool for studying mechanism of action.
		366-04-013. Advancing CEST Imaging: Enhanced Spectral and Spatial Resolution with ESRGAN Transfer Learning YASHWANT KURMI, Malvika Viswanathan, Zhongliang Zu Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, United States of America Impact: CEST imaging, hindered by low resolution and lengthy scan times, is improved with ESRGAN-CEST, a deep learning framework that enables CEST imaging with enhanced spectral and spatial resolution.
		366-04-014. MRI-Visible Biomimetic Macrophage Membrane Nanoplatform for Theranostic Modulation of Doxorubicin-Induced Myocardial Injury ZhiNan Wang, Xi Liu, Yingshi Sun Peking University Cancer Hospital & Institute, Beijing, China Impact: This study establishes a biomimetic MRI-visible nanoplatform that enables precise diagnosis and targeted therapy of cardiotoxicity, inspiring new strategies for inflammation- and oxidative stress-related cardiac diseases.
		366-04-015. Acute MEMRI Associates With Chronic Scar Burden and Left Ventricular Remodeling After Myocardial Ischemia-Reperfusion Matic Pusovnik, Ellen Calluwe, Swannie Pedron, Thomas Bonnard, Willy GSELL, Stefan Janssens, Uwe Himmelreich KU Leuven, Leuven, Belgium Impact: Clinically translatable manganese-enhanced MRI showed strong correlation between acute injury and established chronic remodeling. Early MEMRI readouts of myocardium viability could serve as a reliable imaging biomarker for anticipating long-term scar burden and left ventricular dilation.