Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Advanced Neuroimaging with MRI: CEST and APT Techniques

Advanced Neuroimaging with MRI: CEST and APT Techniques

Digital Poster

Neuro B

Monday, 11 May 2026

Digital Posters Row B

14:45 - 15:40

Session Number: 361-04

No CME/CE Credit

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This session provides an overview of advanced MRI neuroimaging with a focus on Chemical Exchange Saturation Transfer (CEST) and Amide Proton Transfer (APT) imaging in brain disorders across different magnetic field strengths. The biophysical principles underlying CEST and APT contrast will be introduced, followed by discussion of their implementation at clinical (3T, 5T) and ultra-high-field (7T) MRI. Emphasis will be placed on how field strength influences sensitivity, spectral separation, signal-to-noise ratio, and quantitative accuracy, as well as associated technical challenges such as B₀/B₁ inhomogeneity and SAR. The session will highlight applications of APT and CEST MRI in neurological conditions including brain tumours and stroke. Comparative studies across field strengths will illustrate trade-offs between clinical feasibility and molecular sensitivity. The session will conclude with perspectives on quantification, reproducibility, and translation of CEST and APT techniques into routine neuroimaging.

		361-04-001. 31P-MRSI and APT-CEST at 7T in the follow-up of pediatric brain tumors Evita Wiegers, Sabine Plasschaert, Iris Obdeijn, Hilde Roording, Dennis Klomp, Karleen Oonk, Maarten Lequin, Jannie Wijnen UMC Utrecht, Utrecht, Netherlands Impact: Longitudinal 7T ³¹P-MRSI and APT-CEST enable non-invasive monitoring of pediatric brain tumor metabolism. APT-CEST provides tumor-specific contrast even in pediatric low-grade tumors, offering complementary information to conventional MRI and potential guidance for personalized follow-up and treatment strategies.
		361-04-002. COMPARISON OF AMINO-ACID IMAGING METHODS - AN MR PET STUDY USING APT AND FET-PET IN TREATED GLIOMAS Sandhya M, Vihar Mallapu, Venkatesh Murthy, Imam Shaik NIMHANS, Bengaluru, India Impact: This study is an exploratory study comparing two imaging methods, Amide Proton Transfer (APT) imaging and FET-PET using simultaneous MR PET. If validated, APT may provide a radiation-free, widely accessible alternative for evaluating post-treatment gliomas in centres lacking PET facilities.
		361-04-003. Quantitative MRI in Radiotherapy: First observations on T1/T2/conductivity/ADC/APT variations in two brain cancer patients Stefano Mandija, Martin Schilder, Thierry Meerbothe, Edwin Versteeg, Oscar van der Heide, Alessandro Sbrizzi, Evita Wiegers, Tom Snijders, Thomas Willigenburg, Karin Kleynen, Ernst Smid, An Claes, Cornelis van den Berg University Medical Center Utrecht, Utrecht, Netherlands Impact: This is the first observational study showing distinct changes across multiple quantitative MRI parameters (T1/T2/conductivity/diffusion/amide-proton-transfer) during radiotherapy in two glioblastoma patients within the irradiated region, highlighting their potential use for early response assessment and treatment guidance.
		361-04-004. Longitudinal assessment of CEST MRI in glioblastoma: The impact of tumor treating fields in addition to temozolomide Tim Salomonsson, Antonio Giuri, Malte Knutsson, Anina Seidemo, Faris Durmo, Anna Rydelius, Xavier Sarda, Patrick Liebig, Stefano Casagranda, Sara Kinhult, Mattias Belting, Johan Bengzon, Linda Knutsson, Pia Maly Sundgren Lund University, Lund, Sweden Impact: CEST MRI may reveal subtle molecular and microenvironmental changes associated with TTF therapy in combination with TMZ in glioblastoma. This could enhance treatment monitoring and assessment of therapeutic efficacy, offering complementary information to conventional MRI during longitudinal follow-up.
		361-04-005. Double-Step R1rho-Based Lorentzian Fitting with A Full Steady-State Model Enables Fast CEST Imaging of Acute Ischemic Stroke Shihao Zeng, Huabin Zhang, Shan Huang, Gary Kui Kai Lau, Kannie W. Y. Chan, Jianpan Huang The University of Hong Kong, Hong Kong, China Impact: The proposed DROF method integrates full steady-state model and shows improvement in CEST quantification under short saturation time and relaxation delay. Preliminary results indicate it enables fast CEST scans, essential for emergent conditions such as acute ischemic stroke.
		361-04-006. Reproducible Detection of the Amine (2.75 ppm) Signal in the Human Brain with CEST Imaging at 5T qifan pang, Ruibin Liu, ziqi Yu, ziyi Wang, Shuheng Zhang, Dengrong Jiang, Xingfeng Shao, Fuhua Yan, Xiao-Yong Zhang Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Impact: We successfully detected amine (2.75 ppm) signals in the human brain using high–spectral-resolution chemical exchange saturation transfer (CEST) imaging combined with the PLOF method on a 5 T MRI scanner and evaluated the feasibility and reproducibility.
		361-04-007. Enhancing spectral resolution of low field CEST MRI using high field targets and a windowed transformer model Malvika Viswanathan, YASHWANT KURMI, Zhongliang Zu Vanderbilt University Institute of Imaging Science, Nashville, United States of America Impact: Using our autoregressive windowed transformer, we can reconstruct synthetic high field Z-spectra from low field inputs which can resolve overlapping dips and enhancing peak visibility.
		361-04-008. A framework for rapid, reproducible, and high-fidelity whole-brain multi-pool CEST imaging at 3T Yupeng Wu, Siyuan Fang, Siyuan Wang, Caixia Fu, Yang Song, Jianqi Li Shanghai Key Laboratory of Magnetic Resonance, Shanghai, China Impact: This integrated framework overcomes major barriers to the clinical translation of multi-pool CEST. By providing a rapid, robust, and quantitative end-to-end solution, it enables reliable metabolic imaging for widespread brain pathologies like neurodegenerative diseases.
		361-04-009. Fluid Suppressed Amide Proton Transfer CEST imaging with “Inverse-Z minus One” weighting Mitsuharu Miyoshi, Ryuta Ito, Shotaro Fuchibe, Masahiro Yoshimura, Yoshiyuki Watanabe, Tetsuya Wakayama GE HealthCare, Hino, Japan Impact: The use of Inverse-Z minus One “(1/Z)–1” weighting in Fluid Suppressed-Amide Proton Transfer resulted in a clear reduction of MTR_asym value of fluid-rich regions, compared to the conventional methods.
		361-04-010. Selective Fluid Suppression in APTw Imaging Using a Sigmoid-Based Spillover Correction with ssMT Preservation Stefano Casagranda, Christos Papageorgakis, Mauro Zucchelli, Capucine Cadin, Francesca Branzoli, Lucia Nichelli, Moritz Zaiss, Patrick Liebig Olea Medical, La Ciotat, France Impact: This method enables selective fluid suppression while preserving ssMT-related tumor contrast, unlocking a novel APTw-based biomarker sensitive to both mobile proteins and macromolecules. It may improve lesion characterization and support the development of future molecular-imaging–based analysis strategies in neuro-oncology.
		361-04-011. Self-derived dynamic ∆B0 estimation and correction for robust CEST MRI Sultan Zaman Mahmud, Kevin Ju, Jianping Xu, Peter van Zijl, Hye-Young Heo Johns Hopkins University School of Medicine, Baltimore, United States of America Impact: By enabling dynamic ΔB₀ mapping, rosette-CEST MRI enhances the accuracy of CEST measurements in the presence of subject motion-induced B₀ fluctuations, eliminating the need for additional scans or separate B₀ and CEST alignment.
		361-04-012. Towards Robust In Vivo CEST Quantification: Cluster-derived Adaptive Bounds for Z-spectrum Fitting Shan Huang, Shihao Zeng, Huabin Zhang, Gary Kui Kai Lau, Kannie W. Y. Chan, Jianpan Huang The University of Hong Kong, Hong Kong, China Impact: We present an automated, clustering-informed adaptive fitting pipeline that significantly improves the accuracy and robustness of Z-spectrum fitting in CEST MRI. This adaptable framework outperforms conventional fitting with fixed bounds, offering a robust, automated approach for reliable Z-spectrum quantification.
		361-04-013. Diffusion-based amide chemical exchange saturation transfer signal as a proxy for metabolite diffusion in the human brain Yujin Jung, Youngeun Jeon, Jaeseok Park, Seong-Gi Kim, Sung-Hong Park Korea Advanced Institute of Science & Technology, Daejeon, Korea, Republic of Impact: Diffusion-based amide CEST provides enhanced spatial detail, suggesting its potential to assess metabolite diffusion with higher spatial resolution than diffusion-weighted magnetic resonance spectroscopy.
		361-04-014. GluCEST MRI Monitors Regional Cerebral Glutamate Dynamics Under Variable Brain Activity Narayan Datt Soni, Sunil Khokhar, Anshuman Swain, Halvor Juul, Abeer Mathur, Dipak Roy, Blake Benyard, Paul Jacobs, neil wilson, Dushyant Kumar, RAVI PRAKASH REDDY NANGA, Mohammad Haris, Ravinder Reddy University of Pennsylvania, Philadelphia, United States of America Impact: This study demonstrates the potential of GluCEST MRI to capture real-time, region-specific glutamate dynamics across varying brain activity, highlighting its utility for investigating glutamate dysregulation in both normal physiology and neurological or psychiatric disorders.
		361-04-015. CEST MRI Assessment of Deep Brain Stimulation Effects on Motor Function and Molecular Mechanisms in PD Rats yang wang, guangbin wang, Yang Zhao, 昌许, Tao Gong Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, China Impact: STN-DBS alters striatal protein- and lipid-associated exchanges, detectable by CEST MRI. This provides a noninvasive biomarker to study DBS mechanisms, informs clinical strategies for motor improvement, and enables investigation of bilateral molecular effects and links to behavioral recovery.