Detectable Changes in Dementia
Digital Poster
Neuro A
Wednesday, 13 May 2026
Various types of changes occurring in dementia, predominantly not related to AD.
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566-01-001.
Distinct Microstructural Profiles of Genetic and Multi-Factor Dementia Risk Revealed by Soma and Neurite Density Imaging
Impact: SANDI identifies distinct microstructural phenotypes linked to APOE ε4 and UK Biobank Dementia Risk in midlife adults. Findings support SANDI in earlier, biologically informed risk stratification and for research into divergent cellular pathways underlying genetic and multifactorial dementia vulnerability.
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566-01-002.
Association of impaired cognition with the altered cerebral para- and dia- magnetic susceptibility in atrial fibrillation
Impact: The APART-QSM could precisely detect the alter
microenvironment change of brain induced by the AF disease, suggesting that it
might serve as a potential prodromal imaging marker of apparent and silent
cerebropathy.
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566-01-003.
Neuroinflammatory changes in symptomatic frontotemporal lobar degeneration measured using 7T diffusion-weighted spectroscopy
Impact: In
this study, we show that we can detect signs of neuroinflammation using diffusion
weighted MRS in FTLD patients, but not in presymptomatic carriers. The next
step is to test these results against other markers of neuroinflammation
and neurodegeneration.
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566-01-004.
Arterial spin labeling assessments of cerebral blood flow reflect antisocial behavior symptoms in frontotemporal dementia
Impact: Our findings highlight ASL as a sensitive tool for detecting FTD-related perfusion changes linked to behavioral symptoms. By identifying cortical and subcortical alterations before atrophy occurs, ASL may enable earlier diagnosis, targeted interventions, and improved disease management.
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566-01-005.
Unraveling Fronto-Temporal Architecture: Neuroanatomical Signatures and Cognitive Profiling Discriminate Variants of FTD
Impact: The quantified magnitude and kinetics of neuroanatomical alterations integrated with cognitive profiling establish a definitive framework to characterize the complex neurobiology of frontotemporal-lobar dementia (FTLD), enabling clinically translatable differentiation of its phenotypes and advancing objective evaluation of cognitive-integrity across age-groups.
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566-01-006.
Ex vivo T2*-w MRI and Quantitative Susceptibility Mapping reflect histological iron accumulation in Frontotemporal Dementia
Impact: This study shows increased iron accumulation in FTLD vs controls. Ex vivo T2*-w MRI and
QSM have complementary value to visualize the histological changes. Our next step will be to investigate iron
accumulation in vivo in FTLD using 7T MRI.
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566-01-007.
FRONTO-PARIETAL CINGULUM WHITE MATTER CHANGES IN DOWN SYNDROME: CROSS-SECTIONAL AND LONGITUDINAL DIFFUSION MR TRACTOGRAPHY
Impact: This study
identifies spatially-specific trajectories of cingulum degeneration in Down
syndrome using advanced manual tractography dissection, demonstrating that
anterior cingulum microstructure may serve as a sensitive imaging biomarker for
detecting preclinical Alzheimer's-related neurodegeneration prior to symptom
onset.
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566-01-008.
The Relationship between the ALPS Index, Free Water and Cognition in Cognitive Impairment
Impact: ALPS index and free water diffusion MRI markers are associated with cognitive
impairment and aging, which may serve as a biomarker of specific neuropathology in Mild Cognitive Impairment. These results improve upon current knowledge of dementia and its
assessment.
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566-01-009.
Distinct associations of oxygen extraction fraction with clinical biomarkers in Alzheimer’s and non-Alzheimer’s dementias
Impact: This study demonstrates that QQ-based OEF mapping is a
practical imaging biomarker for differentiating Alzheimer’s and non-Alzheimer’s
dementias. It advances understanding of their distinct oxygen-related
pathophysiology and will enable more precise diagnosis and targeted treatment
strategies.
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566-01-010.
Microstructural Brain Alterations in Mild Behavioral Impairment: A Diffusion Tensor Imaging Study of Emotional Dysregulation
Impact: The study
highlights clinical potential of early
neuronal damage biomarkers and proposes ED of MBI as a significant prodromal
dementia correlate, providing a robust and sensitive DTI framework for its
detection and application in future intervention research.
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566-01-011.
Investigation of microstructural signatures of dementia subtypes.
Impact: Combining information of advanced diffusion and magnetization transfer metrics in neurodegenerative dementias could be beneficial to quantify microstructural changes for research and clinical practice.
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566-01-012.
Novel Whole-Brain T1 Mapping Method for Investigation of the Blood-Brain Barrier in a Vascular Disease Cohort
Impact: This study introduces a rapid whole-brain T1-mapping approach to evaluate blood–brain barrier integrity validated against dynamic contrast imaging. The method may measure BBB leakage linked to carotid stenosis, offering a clinically feasible alternative for assessing vascular contributions to dementia.
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566-01-013.
Faster cerebral blood flow reduction is associated with amyloid burden and cognitive decline: a longitudinal study
Impact: The
present study fills the gap through conducting both cross-sectional and
longitudinal studies to investigate the relationship between CBF changes with amyloid
burden and cognitive functions, demonstrating that cerebrovascular decline
tracks both amyloid pathology and cognitive impairment over time.
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566-01-014.
Impact of Modifiable Lifestyle Factors on Dementia Subtypes and Brain Structural Changes in Individuals with Impaired Kidney
Impact: This work provides crucial evidence for clinicians to recommend multifaceted lifestyle interventions to their kidney disease patients, offering a viable strategy to protect brain health and reduce dementia risk in this vulnerable population.
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566-01-015.
Patterns of altered DTI metrics in arousal pathways and their association to sleep-wake activity in Dementia with Lewy Bodies
Impact: By linking structural
connectivity within brainstem–thalamic-cortical arousal pathways to measurable
sleep–wake instability, we provide mechanistic insight into early
dysfunction in Dementia with Lewy Bodies. These results open avenues for
multimodal biomarkers combining actigraphy and diffusion imaging to detect
prodromal disease.
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566-01-016.
Cumulative blood pressure exposure, brain volume, perfusion, and cognitive function: A population-based prospective study
Impact: This study identifies cumulative blood pressure burden as a key determinant of brain atrophy, hypoperfusion, and cognitive decline in the general population. Quantifying long-term BP exposure may improve risk prediction and highlight the importance of sustained vascular control for health.
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