Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

Everything About Contrast Mechanism

Flash Presentation

Contrast Mechanisms

Thursday, 14 May 2026

Roof Terrace

13:40 - 15:16

Moderators: Markus Barth & Curtis Corum

Session Number: 631-02

No CME/CE Credit

Similar Sessions

This session cover a comprehensive list of the fundamental and advanced MR contrast mechanisms.

13:40		631-02-001. Comparison of Quantitative Mapping and Radiologist Grading of WM Features Seen with divided Subtracted Inversion Recovery Maryam Tayebi, Paul Condron, Mark Bydder, Gil Newburn, Daniel Cornfeld, Eryn Kwon, Miriam Scadeng, Tracy Melzer, Samantha Holdsworth, Graeme Bydder Mātai Medical Research Institute, Gisborne, New Zealand Impact: Quantitative mapping of signal in white and grey matter correlated strongly with radiological grading in 87 subjects examined with divided subtracted inversion recovery sequences. The study provides a quantitative basis for interpreting subjective whiteout and grayout signs in disease.
13:42		631-02-002. Optimized High-Resolution ASL Perfusion Imaging with Joint Motion-Correction and Low-Rank Reconstruction Minhao Hu, Frederik Lange, Peter Jezzard, Mark Chiew, Thomas Okell Centre for Integrative Neuroimaging, FMRIB Centre, University of Oxford, Oxford, United Kingdom Impact: Optimization by combining advanced acquisition, reconstruction and motion correction enables robust high-resolution ASL at 2.0mm isotropic resolution, advancing clinical feasibility for detailed perfusion assessment in neurovascular disease.
13:44		631-02-003. Towards Clinically Feasible Susceptibility Tensor Imaging: DTI-Informed Reconstruction from Minimal Orientations Li-Chen Kuo, Ming-Long Wu National Cheng Kung University, Tainan, Taiwan Impact: DISTI enables clinically feasible susceptibility tensor imaging through 67% scan time reduction while improving accuracy. This facilitates routine assessment of tissue anisotropy in neurological disorders, opening investigations into white matter pathologies and diseases where susceptibility provides unique complementary microstructural insights.
13:46		631-02-004. Generating novel contrast for myocardium assessment with periodic irradiation of RAFF2 pulses Elias Ylä-Herttuala, Hanne Laakso, Svetlana Laidinen, Timo Liimatainen, Shalom Michaeli University of Eastern Finland, Kuopio, Finland Impact: This study presents novel application of the optimization of RAFF2 technique for quantitative ex vivo assessment of myocardium after chronic infarct and healthy myocardium. This method allows to study physiological changes in the myocardium.
13:48		631-02-005. Time-efficient interleaved spin density-weighted and inversion recovery 23Na MRI at 7 Tesla Fiona Meyer, Armin NAGEL, Jordan Hoehn, Laurent Ruck, Nico Egger, Michael Uder, Tobias Wilferth University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany Impact: This work demonstrates the feasibility of time-efficient interleaved spin density-weighted and inversion recovery ²³Na MRI within one single sequence at 7 Tesla. The approach may facilitate the integration of both of the complementary contrasts in clinical research study protocols.
13:50		631-02-006. Paramagnetic-to-diamagnetic susceptibility ratio as an imaging marker to detect glioblastoma infiltration Giulia Debiasi, Giovanni Librizzi, Valentina Visani, Marco Castellaro, Zhenghao Li, Hongjiang Wei, Renzo Manara, Alessandra Bertoldo, Chunlei Liu University of California, Berkeley, United States of America Impact: The infiltration of tumor outside the core of glioblastoma hampers its complete removal during surgical resection and radiotherapy. We developed an iron-related imaging marker of abnormal areas within edema to identify tumor infiltration and aid treatment planning at single-patient level.
13:52		631-02-007. ZIF-8 film-based 1H/129Xe dual-modal MRI interventional guidewire Xinxin Yang, Qianni Guo, Qingbin Zeng, Xiuchao Zhao, Zhen Wang, zhongyu xiao, Yanling Feng, Yaping Yuan, Chenlu Yuan, Sa Xiao, Xin Zhou Innovation Academy for Precision Measurement Science and Technology,CAS, Wuhan, China Impact: We established a materials-and-imaging proof-of-concept in which a thin ZIF-8 film renders a device surface selectively visible on ¹²⁹Xe MRI, while ¹H MRI supplies anatomy. The method decouples conspicuity from embedded RF hardware and may help reduce RF heating risks.
13:54		631-02-008. Sodium MRI Quantification: Agreement Between Endogenous and Exogenous Calibration Zuqi Xia, Nengjin Zhu, Yunyu Gao, Liwei Mazu, Siyuan He, Jianping Chu The First Affiliated Hospital, Sun Yat-sen University, China Impact: This study provides direct evidence regarding the agreement between the endogenous vitreous humor reference and exogenous phantom as calibration references in sodium MR quantification. These findings establish a methodological foundation for advancing quantitative calibration strategies of sodium MRI.
13:56		631-02-009. Intrinsic Waveguide MR Elastography of the Human Brain Kulam Najmudeen Magdoom, Julian Rey, Alexandru Avram, Joelle Sarlls, Anthony Romano, Szymczak William, Peter Basser Eunice Kennedy Shriver - National Institute of Child Health and Human Development (NICHD), Bethesda, United States of America Impact: We have developed a MRE method to measure the anisotropic mechanical properties in white matter without using a tamper. The method has the potential to detect subtle changes in the brain structure that may occur in disease.
13:58		631-02-010. Validation of QTMnet based kinetic parameter mapping using a whole brain perfusion simulation Benjamin Weppner, Qihao Zhang, Dominick Romano, Renjiu Hu, Ilhami Kovanlikaya, Pascal Spincemaille , Yi Wang Cornell University, Ithaca, United States of America Impact: QTMnet provides a more accurate and robust flow estimation without requiring AIF selection compared to traditional kinetic methods.
14:00		631-02-011. Zero Is Not a Magic Number: Bias from Excluding Negative Ktrans in Hippocampal DCE-MRI Irene Mikkelsen, Malene Kaasing, Ryan Sangill, Dora Grauballe, Lasse Madsen, Louisa Erichsen, Pernille Kjeldsen, David Brooks, Simon Eskildsen, Leif Østergaard Aarhus University, Aarhus, Denmark Impact: Researchers studying hippocampal BBB leakage in Alzheimer’s disease must recognize that negative K_trans values, though seemingly non-meaningful, may reflect noise. Applying a zero threshold inflates leakage estimates. Smarter DCE-MRI noise modeling is needed to exclude only truly uninformative values.
14:02		631-02-012. Reproducibility, sex and age effects on neuromelanin MRI. Begona Garate, Antonio Martín-Bastida, Marta Vidorreta, María Cruz Rodríguez-Oroz, Maria Fernandez-Seara Clinica Universidad de Navarra, Pamplona, Spain Impact: The neuromelanin (NM) contrast and reproducible volumetric delineations based on a 3D GRE sequence with magnetization transfer pulse could facilitate the use of NM-MRI as a biomarker of Parkinson's disease in clinical imaging.
14:04		631-02-013. Hybrid ¹H-MRS and CEST-MRI approach for in vivo quantification of neurogenesis-linked bioimaging marker in embryo brain Mariano Uberti, Aditya Bade, Yutong Liu University of Nebraska Medical Center, Omaha, United States of America Impact: This study introduces a validated hybrid ¹H-MRS-CEST framework that enables in vivo quantification of neurogenesis-linked oleic acid (OA) during embryonic development, providing a non-invasive tool that has a potential to elucidate the neurogenesis process.
14:06		631-02-014. Chemical Exchange Saturation Transfer (CEST) MRI for Non-invasive Molecular Imaging in Renal Transplant Recipients Valensia Anthony, Ding Xia, Mira Liu, Ian Bolger, Samira Farouk, Octavia Bane, Sara Lewis, Li Feng, Xiang Xu Icahn School of Medicine at Mount Sinai, New York, United States of America Impact: This study demonstrates the feasibility of CEST MRI for free-breathing, contrast-free molecular imaging in kidney grafts, which may potentially provide evaluation of tissue acidosis, ischemia, renal function, and fibrosis
14:08		631-02-015. Measuring cerebral microvascular pulsatility using cardiac-synchronized pCASL with segmented stack-of-star radial acquisition Tianrui Zhao, Jianing Tang, Yining He, Lirong Yan Northwestern University, Chicago, United States of America Impact: We present a novel MRI technique with good feasibility for measuring cerebral microvascular pulsatility. It offers a valuable tool for assessing cerebral microvascular function, with potential applications in studies of aging, neurodegenerative disease, and small vessel disease.
14:10		631-02-016. Multi-parametric MRI reveals reduced Cerebral Perfusion and Oxygen Metabolism During Midazolam Sedation Eleonora Patitucci, Neeraj Saxena, Hannah Chandler, Ian Driver, Emma Morgan, Elena Stylianopoulou, Zoltan Auer, Murthy Varanasi, Richard Wise, Sharmila Khot, Michael Germuska Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom Impact: This study shows that dual-calibrated fMRI can quantify sedation-induced physiological changes, revealing region-specific metabolic suppression during midazolam administration and demonstrating the potential of multi-parametric MRI to inform safer anaesthetic management by identifying regions vulnerable to hypometabolism or perfusion dysregulation.
14:12		631-02-017. Spillover-, ssMT-, and T1-Corrected APTw MRI Improves the Distinction of IDH Status and 1p/19q Codeletion in Brain Gliomas Stefano Casagranda, Capucine Cadin, Bertrand Mathon, Ottavia Dipasquale, Christos Papageorgakis, Mauro Zucchelli, Emmanuel Mandonnet, Stéphane Lehéricy, Marc Sanson, Patrick Liebig, Moritz Zaiss, Lucia Nichelli, Francesca Branzoli Olea Medical, La Ciotat, France Impact: Spillover-, ssMT-, and T₁-corrected APTw MRI improves the specificity of protein-related contrast and facilitates differentiation of glioma molecular subtypes, supporting its integration into multiparametric clinical protocols for non-invasive IDH and 1p/19q stratification.