Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

fMRI: Preclinical

Digital Poster

Brain Function & fMRI

Wednesday, 13 May 2026

Digital Posters Row C

16:55 - 17:50

Session Number: 562-06

No CME/CE Credit

Similar Sessions

This session presents functional imaging techniques and findings in preclinical animal models.

		562-06-001. GOing Beyond Activation: Gene Ontology Terms for Functional Interpretation of fMRI Data Isabel Wank, Anja Amthor, Christian Müller, Andreas Hess Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany Impact: Integrating rCBV imaging with publicly available gene expression data (Allen Institute) links retinoic acid metabolism to neutral sphingomyelinase-dependent ethanol aversion, revealing molecular pathways that connect brain responses to alcohol with genetic mechanisms relevant to alcohol use disorder.
		562-06-002. Rear-Projection Visual Display System for Awake Mouse fMRI Geun Ho Im, SangHan Choi, SeungYub Lee, HyungGoo Kim, Seong-Gi Kim Institute for Basic Science, Suwon, Korea, Republic of Impact: We developed a rear-projection visual display system for awake mouse fMRI studies at 15.2T, and obtained whole-brain fMRI during moving grating stimulation. This system allows the presentation of diverse visual stimuli within the small-bore MRI scanner.
		562-06-003. Chemogenetically-Evoked Neurochemical Dynamics and Interhemispheric Metabolic Coupling Probed by ¹H-fMRS Nathalie Just EPFL, Lausanne, Switzerland Impact: This work links targeted neuromodulation to real-time neurochemical and BOLD responses across hemispheres, enabling circuit-level insight into excitatory–inhibitory balance. The approach may guide biomarkers and therapies for disorders with disrupted interhemispheric communication, such as stroke and motor network diseases.
		562-06-004. Brain Network Dynamics Under Graded Sweet Stimuli in Awake Mice ZEPING XIE, Jiaying Li, Jianyu Yuan, Yuanxi Shen, Pingfu Wang, Hongtao Zhang, Jie Chen, Linyan Wang, Yi He Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China Impact: This work establishes an awake-fMRI paradigm for quantifying how sweetness intensity reorganizes sensory and associative brain networks, providing a foundation for mechanistic studies of gustatory processing and neuro-metabolic regulation.
		562-06-005. Effects of injury to primary motor cortex on resting state BOLD signals in the white matter of spinal cord Anirban Sengupta, Pai-Feng Yang, Arabinda Mishra, Feng Wang, Jamie Reed, Li Min Chen, John Gore Vanderbilt University Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, United States of America Impact: The current study provides foundational work for researchers and clinicians to use WM resting state BOLD signals from spinal cord as a useful physiological biomarker to study various neuro-disorders and evaluate functional outcomes post a motor cortex injury.
		562-06-006. Investigating resting-state fMRI connectivity in rat spinal cord by localized epidural lidocaine injection Chaoqi Mu, Feng Wang, John Gore, Li Min Chen Vanderbilt University Medical Center, Nashville, United States of America Impact: This approach could be used to further dissect intraspinal circuitry and study the functional relevance of spinal cord resting-state functional connectivity through selective and direct manipulation of spinal cord nerve roots activity and connections.
		562-06-007. Spatial structure of intrinsic brain activity in resting-state fMRI and wide-field optical imaging Shella Keilholz, Wen-Ju Pan, Lauren Daley, Lisa Meyer-Baese Emory/Georgia Tech, Atlanta, United States of America Impact: This work helps researchers to interpret resting-state functional MRI studies in terms of the underlying neural activity and hemodynamics.
		562-06-008. Endogenous oxytocin release dynamically modulates fMRI connectivity Alessandro Gozzi, Caterina Montani, Andrew Hayward, Giovanni Morelli, Simone Malerba, Yongsoo Kim, Massimo Pasqualetti, Stefano Panzeri, Laura Cancedda, Elizabeth De Guzman Istituto Italiano di Tecnologia, Rovereto, Italy Impact: This study introduces a chemogenetic-fMRI framework to visualize the whole-brain impact of endogenous neuromodulator release, enabling causal investigation of how oxytocin and similar neuropeptides endogenously reorganize dynamic network states
		562-06-009. 17.2T MRI for multimodal characterization and parcellation of mouse hypothalamus Pierre Labouré, Alicia Sicardi, Ivy Uszynski, Vincent Prévot, Luisa Ciobanu CEA NeuroSpin, Paris-Saclay University, CNRS, Gif-Sur-Yvette, France Impact: This study provides baseline multimodal measurements of the wild-type mouse hypothalamus along with a high-resolution 17.2T atlas, supporting identification of nuclei-specific structural, diffusion and functional features and serving as a reference for future studies of disease-related alterations.
		562-06-010. Space–Frequency SVD Reveals Reciprocal Neural Dynamics During Social Interaction Between Two Awake Mice Xiaochen Liu, Hyun Seok Moon, David Hike, Changrun Lin, Nivetha Pasupathy, Yuanyuan Jiang, Xiaoqing Zhou, Xin Yu Massachusetts General Hospital and Harvard Medical School, Boston, United States of America Impact: We used SVD to identify a ~0.7 Hz inter-brain oscillation and a consistent coherence-based phase offset in the anterior cingulate cortex. This establishes a two-awake-mouse fMRI platform for probing reciprocal neural mechanisms underlying social deficits in neurological and psychiatric disorders.
		562-06-011. Effects of Mild Body Temperature Changes on Brain Temperature, Blood Flow, Metabolites and Functional Connectivity in Mice Xiaodong Zhang, Shuai YAO, Fuyu MAI, Zhenlong HU, Qing ZHANG, Yiting XU, Zhong ZENG, Wenjing XU, Rong Wang, Pengzhan Xu, Qiliang Du, Haiwei Shan, Xiangning LI, Hongxia Lei, Xin Zhou, Qian LIU State Key Laboratory of Digital Medical Engineering, Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Sanya, China Impact: The study exhibited the effects of body temperature on the brain and may advance the understanding of the physiological effects of environment temperature changes on the central nervous system with clinical MR implications.
		562-06-012. Osteocalcin-induced brain states shift from basic to "salient" and highlight its potential role in antidepressant strategies Natalia Freus, Christian Müller, Andreas Hess, Silke Kreitz Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany Impact: Osteocalcin induces specific resting-state fMRI brain states in mice which are involved in anxiety and depression. These insights support osteocalcin as a new possible anti-depressant mechanism which might lead to new treatment options, especially for treatment-resistant patients.
		562-06-013. Mapping Brain-Wide Functional Connectivity in an Awake Schizophrenic Mouse Model Nivetha Pasupathy, David Hike, Xiaochen Liu, Charles Reilly, William Xu, Yuanyuan Jiang, Jen Pan, Xin Yu, Xiaoqing Zhou Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America Impact: This study links a schizophrenia-associated CaV3.3 mutation to hyperconnectivity in the thalamocortical network and sets the stage for integrating concurrent ACC fiber photometry with whole-brain fMRI to reveal how disrupted TRN–ACC regulation drives network dysfunction in schizophrenia.
		562-06-014. Comparing the performance of qBOLD models to quantify oxygen extraction fraction using Monte Carlo over mice angiograms Alexis Cinq-Mars, Ghislain Tedondje, Aurelie Beaudoin, Michèle Desjardins, Louis Gagnon Université Laval, Québec, Canada Impact: Quantifying the accuracy of qBOLD models against a ground-truth will provide confidence to researchers and clinicians to use the technique to measure OEF in healthy and diseased brain and might help improving the method.
		562-06-015. Functional MRI Reveals Somatosensory Delta Rhythms Drive the Strongest Brain-wide Activation among Sensorimotor Cortices Junjian Wen, Linshan Xie, Yankai Zhang, Ed X Wu, Alex T. L. Leong The University of Hong Kong, Hong Kong, China Impact: This study reveals region-specific modulation by delta phase over brain-wide gamma and BOLD activity, elucidating mechanisms of network recruitment. It informs cortical neuromodulation by guiding spatially targeted selection of stimulation sites to enhance efficacy and minimize off-target effects.
		562-06-016. Magnetic Resonance Imaging of Outbred Rats before and after escalation of alcohol intake David Berry, Michael Keaser, Abraham Palmer, Giordano de Guglielmo, Joyce Da Silva, Lieselot Carrette University of California, San Diego, United States of America Impact: This study uses longitudinal multi-parametric MRI in genetically diverse rats to distinguish pre-existing from alcohol-induced brain differences underlying vulnerability to alcohol addiction. These findings lay the groundwork for predictive biomarkers and personalized strategies to prevent and treat alcohol use disorder.