Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Spectroscopy and Spectroscopic Imaging: Applications

Spectroscopy and Spectroscopic Imaging: Applications

Digital Poster

Contrast Mechanisms

Thursday, 14 May 2026

Digital Posters Row I

09:25 - 10:20

Session Number: 668-02

No CME/CE Credit

Similar Sessions

This session highlights diverse applications of MRS and MRSI.

		668-02-001. 1H-MRS brain metabolites as biomarkers of high-altitude hypobaric hypoxia following mild traumatic brain injury in mice Young Woo Park, Alexandru Korotcov, Asamoah Bosomtwi, Nathan Cramer, Xiufen Xu, Dinesh Deelchand, Malgorzata Marjanska, Zygmunt Galdzicki The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, United States of America Impact: High-altitude hypoxia alters brain metabolism and may reduce brain resilience to mild TBI. MRS reveals neurochemical markers of hypobaric hypoxia indicating neurophysiological alterations with implications for military and civilian populations operating in sustained high altitude environments and space travel.
		668-02-002. Brain GABA and glutathione in people living with HIV Muhammad Saleh, Reza Abdavies, Lisa Blaskey, Luke Bloy, Funmi Aka-Bashorun, Saipavitra Murali-Manohar, Timothy Roberts, Elizabeth Lowenthal, Robert Gross, William Short Children's Hospital of Philadelphia, Philadelphia, United States of America Impact: Brain GABA and GSH are essential for brain development and defense against harmful elements. This study found that HIV presence affects MRS-measured GABA, while smoking and normal aging influence GSH.
		668-02-003. Impaired Neurometabolism in Severe Amyotrophic Lateral Sclerosis Condition: A 1H-[13C]-NMR Analysis in SOD1G93A Mice Anant Patel, Sohini Ghosh CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India Impact: The neurometabolic activity provides an accurate measure of the degree of motor impairment in ALS conditions.
		668-02-004. Retrospective frequency and phase correction improves SNR and quantification for human brain 31P MRS at 7T Chu-Yu Lee, Jia Xu, Baolian Yang, Jordan Schultz, Peggy Nopoulos, Vincent Magnotta University of Iowa, Iowa City, United States of America Impact: Corrections for the gradient heating or subject motion-induced frequency/phase offsets were shown to improve spectral SNR and metabolite quantification for human brain phosphorus MR spectroscopy. Integration of the correction to the data processing may help more accurately characterize bioenergetic abnormalities.
		668-02-005. An Automated Reference Based Method for Frequency, Phase, and Baseline Alignment in Quantitative Exchanged Label Turnover MRS Claire Vania, Ritambhar Burman, Kasturee Chakraborty, Ongira Chowdhury, Puneet Bagga St. Jude Children's Research Hospital, Memphis, United States of America Impact: This automated baseline-referenced alignment enables accurate correction of spectral drift across separate MRS scans, improving metabolic analysis in QELT-MRS. It facilitates reliable detection of labeling-induced changes, supporting robust metabolic imaging in research and potential clinical translation.
		668-02-006. Evaluating metabolites in metastatic ovarian tumors with and without cytotoxic treatment using 3T MR spectroscopy Roshni Parameswaran, Imam Shaik, Pooja Patkulkar, Victor Raj, Manoj Kumar, Vivek Tiwari, Anuradha Chandramohan, Sanhita Sinharay Indian Institute of Science, Bangalore, India Impact: This study demonstrates that ¹H-MRS can identify metabolic changes associated with chemotherapy response in ovarian cancer, highlighting its potential as a noninvasive imaging biomarker for early treatment monitoring and improved assessment of therapeutic efficacy in gynecologic oncology.
		668-02-007. Constraining water dMRI microstructure models with dMRS-derived soma radii Rita Oliveira, Malte Brammerloh, Tan Toi Phan, Eloïse Mouge, Thanh Phong Lê, Jessie Mosso, Cristina Cudalbu, Ileana Jelescu Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland Impact: In this work, soma radii derived from metabolite dMRS, were used to inform water dMRI models (SANDI, SANDIX), improving the robustness of parameter maps. While further work is needed, this marks a promising step toward combining dMRS and dMRI.
		668-02-008. Capturing hippocampal inflammation using diffusion-weighted MR spectroscopy (dw-MRS) and multi-compartment diffusion metrics Jason Langley, Ilana Bennett, Xiaoping Hu University of California Riverside, Riverside, United States of America Impact: Glial cells constitute approximately half of brain tissue but their contributions to multi-compartment diffusion metrics are often overlooked. Here, we use diffusion-weighted MRS to extract glial-specific metrics and explore their relationship with multi-compartment diffusion metrics in the hippocampus.
		668-02-009. 31P magnetic Resonance Spectroscopy of the thigh muscles in sarcopenia Zaizhu Zhang, Jinxia ZHU, xiaoming Liu, Fengdan Wang, Shaoqing Zhu, Caixia Fu, Xiaoye Wang, Feng Feng Peking Union Medical College Hospital, Beijing, China Impact: ³¹P-MRS enables noninvasive, quantitative evaluation of skeletal muscle metabolism. Metabolic markers such as the PCr/Pi ratio may serve as objective indicators of early sarcopenia, complementing conventional structural assessments and facilitating earlier diagnosis and intervention.
		668-02-010. Mapping of GABA and Glutamate in Tuberous Sclerosis Complex Using Edited-MRSI at 3T Dillip K. Senapati, Helge Zoellner, İpek Özdemir, Georg Oeltzschner, Ryan Gill, Jacqueline Harris, Peter Barker, Doris Lin Johns Hopkins University School of Medicine, Baltimore, United States of America Impact: Voxel-wise GABA-edited MRSI showed elevated GABA+ and Glx across tissue types in TSC, suggesting disrupted inhibitory-excitatory balance. These findings highlight potential of GABA-edited MRSI for understanding neurochemical mechanisms in TSC.
		668-02-011. Metabolic Alteration in the Midbrain-Striatal Circuit in Parkinson's Disease: A MEGA-PRESS-based MRS Study Min Xie, Zhenxing Wu, Xue Xu, Yu Xia, Nan Jiang, Xiance Zhao, Peng Wu, Rifeng Jiang Fujian Medical University, Fuzhou, China Impact: Identifying PD’s region-specific metabolic network dysregulation and neurochemical changes provides new quantitative evidence for understanding its pathology and guides targeted neurochemical system intervention.
		668-02-012. Sleep-related changes in 1H MRS-visible macromolecules Carina Volk, Valeria Jaramillo, Reto Huber, Ruth O'Gorman Tuura University Children's Hospital Zurich, Zurich, Switzerland Impact: Noninvasive methods for evaluating brain clearance are of increasing interest, given the importance of clearance processes for brain health. Macromolecular signals from MRS may represent a promising noninvasive marker for brain clearance, complementary to neurofluid transport markers from MRI.
		668-02-013. Assessment of diurnal metabolism in lumbar paraspinal muscles in vivo using 31P-MRS at 3T Xiaoqing Liang, Ying Li, Chen Lin, Wenhao Wang, Luxiang Liang, Yong Zhang, Liangjie Lin The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Impact: This study provided a reference for exploring the application of ³¹P-MRS in systemic muscle metabolism and pathological changes in clinical practice.
		668-02-014. Regional Alterations in Brain Energy and Membrane Phospholipid Metabolism in Smokers: A 31P Chemical Shift Imaging Study Ruiping Zheng, Liangjie Lin, Chunxiao Bu, Wenhao Wang, 国豪 123456, Yong Zhang The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Impact: This study reveals region-specific metabolic disturbances in the smoking brain, highlighting altered energy balance and membrane metabolism underlying cognitive and neurologic effects. The frontal lobe demonstrates pronounced alterations, offering insights into neurobiologic mechanisms of smoking-related cognitive and neurologic risks.
		668-02-015. Revisiting an Aspect of GBCA Stability in the Context of Copper Metabolism Disorders through Relaxometry Insights Patrick Werner, Matthias Taupitz, Susanne Wagner, Leif Schröder German Cancer Research Center (DKFZ), Heidelberg, Germany Impact: Presence of Cu²⁺ significantly increases the release of Gd³⁺ from GBCAs in the presence of glycosaminoglycans. This may increase the risk of gadolinium deposits in cases of copper-metabolism disorders, and this link should be further investigated in future research.