Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Neuroimaging and Spectroscopy in Experimental Models

Neuroimaging and Spectroscopy in Experimental Models

Oral

Preclinical

Monday, 11 May 2026

Hall 1A

13:50 - 15:40

Moderators: Patryk Filipiak & Priyanka Bhat

Session Number: 301-03

CME/CE Credit Available

Similar Sessions

Preclinical Neuro session comprising structural and functional MRI, MRE, and NMR metabolomics across species.

Skill Level: Basic

13:50		301-03-001. Ultra-high gradient strength diffusion MRI for mapping axonal architecture and microstructure in the primate brain Ting Gong, Chiara Maffei, Dongsuk Sung, Elissa Bell, Jasmine Shao, Jingjing Wu, Emma Rosenblum, Gabriel Ramos Llordén, Alina Müller, Mirsad Mahmutovic, Boris Keil, Jean Augustinack, Susie Huang, Suzanne Haber, Anastasia Yendiki Massachusetts General Hospital and Harvard Medical School, Boston, United States of America Impact: We present the most comprehensive sampling of the macaque and human brain with diffusion MRI to date. These data provide unprecedented insights about fiber pathways and microstructure in the primate brain, thus are a valuable resource for neuroscience studies.
14:01		301-03-002. Multimodal MRI Assessment of Structural and Diffusion Alterations in a Non-Human Primate Model of Alzheimer’s Disease Ching-Wen Chang, Ssu-Ju Li, Boyi Qu, Yao-Wen Liang, Yu-Qian Ke, Cheng-Ru Yang, Ting-Chieh Chen, Zhi-Shin Cheng, Yi-Ren Lin, Yi-Duan Chen, You-Yin Chen, Hsin-Yi Lai National Yang Ming Chiao Tung University, Taipei, Taiwan Impact: This work identifies structural and diffusion imaging biomarkers for Alzheimer's disease detection in macaques using AAV-Tau P301L transduction. Results advance translational research relevant to human AD, enabling improved disease monitoring and supporting development of novel therapeutics.
14:12		301-03-003. State-Dependent Functional Connectivity Revealed by Multimodal Awake fMRI–Calcium Imaging in Mice Francesca Mandino, Taekyung Kang, Xilin Shen, Corey Horien, Xenophon Papademetris, Stephen Strittmatter, Evelyn Lake Yale School of Medicine, Department of Radiology & Biomedical Imaging, New Haven, United States of America Impact: This innovative multimodal imaging platform enables robust longitudinal simultaneous fMRI and WF-Ca²⁺ imaging in awake mice. It provides a unique multi-contrast framework for translational neuroscience, by offering access to brain network physiology across the full-range of brain and behavioral states.
14:23		301-03-004. High-Resolution fMRI Reveals Thalamic Low-Pass Filtering of Cortical Frequency Tuning Zijuan Yu, Haoyu Wang, Yan Zhuo, Zhentao Zuo National Key Laboratory of Cognitive Science and Mental Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China Impact: By integrating high-field fMRI with optogenetics and DCM, this study shows that MRI can uncover circuit-level mechanisms of sensory gating, establishing a framework for linking frequency-dependent BOLD responses to thalamocortical information transfer in vivo.
14:34		301-03-005. MR Elastography Reveals Hormone-Related Hippocampal Mechanical Property Changes During the Menopausal Transition Sabrina Vander Wiele, Katrina Milbocker, Meggan Bischoff, Kaelin Penna, Anna Klintsova, Curtis Johnson University of Delaware, Newark, United States of America Impact: This study demonstrates MR elastography's ability to noninvasively detect hormone-related changes in hippocampal mechanics during different stages of menopause and its potential as a biomarker for early brain alterations that may contribute to increased risk for neurodegenerative diseases in women.
14:45		301-03-006. The Role of AIM2-mediated PANoptosis in Cerebral Ischemia/Reperfusion Injury: A Multimodal MRI Study of the Ischemic Penumbra Xiaoli Wang, Haimo Zhang, Xiaozu Zhang, Youcheng Qin, Zhigang Yang, Chen Li, Zhen Li, Xizhen Wang, Peng Wu Shandong Second Medical University, Weifang, China Impact: This study identifies AIM2-mediated PANoptosis as a key mechanism in the ischemic penumbra, providing a new therapeutic target and a non-invasive MRI method for monitoring treatment efficacy in ischemic stroke.
14:56		301-03-007. Common pallidal structural remodeling underlying diverse antidepressant actions revealed by mouse VBM Yoshifumi Abe, Kenji Tanaka Keio University School of Medicine, Tokyo, Japan Impact: This study identifies a common structural signature of antidepressant action in the mouse pallidum using MRI. Revealing shared brain remodeling across diverse antidepressants provides new insight into neural mechanisms of recovery and suggests structural biomarkers for evaluating antidepressant efficacy.
15:07		301-03-008. Loss of Metabolic Resilience with Reproductive Aging in Female 5xFAD Mice: A ¹H-[¹³C]-NMR Analysis Akila Ramesh, Anant Patel CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India Impact: Reproductive aging influences Alzheimer’s pathology in female AD mice, likely through hormonal changes that influence neuronal metabolic activity. These findings highlight the need to consider sex and age when designing therapeutic strategies for more precise and effective interventions.
15:18		301-03-009. Metabolomic and cell viability of live rat 3D-brain organoids in an in-house-designed bioreactor for MRS and MRI at 9.4 T Eloise Mougel, Pauline Léal, Tan Toi Phan, Cristiana Centofanti, Marc Lanzillo, Rita Oliveira, Dario Sessa, jocelyn Grosse, Katarzyna Pierzchala, Ileana Jelescu, Olivier Braissant, Cristina Cudalbu, Thanh Phong Lê CIBM Center for Biomedical Imaging, Lausanne, Switzerland Impact: This work demonstrates that living 3D brain organoids remain viable for 6 hours in a horizontal MRI magnet using an in-house developed bioreactor, enabling metabolomic profiling and paving the way for studying cellular and metabolic changes in pathological conditions.
15:29		301-03-010. Multimodal MRI Reveals Melatonin-Induced Oligodendrogenesis Through AKT/GSK-3β/β-Catenin Signaling in PWMI rats Xiaoli Wang, Xiaozu Zhang, Haimo Zhang, Youcheng Qin, Zhigang Yang, Xiaotian Gao, Yijing Wang, Peng Wu, Xizhen Wang Shandong Second Medical University, Weifang, China Impact: Multimodal MRI provides a non-invasive imaging tool for the diagnosis and treatment of PWMI. Additionally, Mel can promote myelination via the AKT/GSK3β/β-catenin pathway, which in turn lays a theoretical foundation for the clinical application of Mel in PWMI.