Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

Type 2 Diabetes

Digital Poster

Neuro B

Tuesday, 12 May 2026

Digital Posters Row I

09:15 - 10:10

Session Number: 468-02

No CME/CE Credit

Similar Sessions

The session looks at research in Type 2 Diabetes and how it impacts both the body and the brain. Multiple imaging techniques are covered in this session

		468-02-001. Iron Homeostasis Imbalance and Cognitive Dysfunction in Type 2 Diabetes: Insights from Quantitative Susceptibility Mapping Zhenyu Cheng, Meng Li, Qihao Zhang, Jiaxiang Xin, Jing Li, Nan Zhang, Yiwen Chen, Pengcheng Liang, Changhu Liang, Lingfei Guo Binzhou Medical University, Yantai City, Shandong Province, China Impact: This study provides in evidence that iron dysregulation mediates cognitive decline in type 2 diabetes. It highlights quantitative susceptibility mapping as a promising biomarker for early detection, encouraging new research on metabolic–neurodegenerative interactions and preventive strategies for diabetic cognitive impairment.
		468-02-002. Assessing the Oxygen Extraction Fraction in Type Ⅱ Diabetes Mellitus and the relationship with cognitive impairment. Shurong Wu, Fushuai Zhang, Zhenyu Cheng, Yiwen Chen, Pengcheng Liang, Xinxin Huo, Boyao Chen, Jiaxiang xin, Qihao Zhang, Meng Li, Changhu Liang, Lingfei Guo Binzhou Medical University, Yantai City, Shandong Province, China Impact: This study highlights the differences of OEF in different brain subregions between healthy controls and patients with T2DM, and explores the association between the OEF of right amygdala and cognitive scores.
		468-02-003. Thalamic subregions link Type 2 Diabetes Mellitus to slowed processing speed: UK Biobank evidence with Jinan validation Fushuai Zhang, Nan Zhang, Yenan Che, Zhenyu Cheng, Xinxin Huo, Boyao Chen, Pengcheng Liang, Yiwen Chen, Jiaxiang xin, Meng Li, Lingfei Guo Binzhou Medical University, Yantai City, Shandong Province, China Impact: Identification of the mediodorsal medial and paracentral thalamic nuclei provides nucleus-level biomarkers of diabetes-related processing-speed slowing. Partial mediation indicates mechanistic relevance and actionable targets for risk stratification and speed-preserving interventions in at-risk T2DM populations.
		468-02-004. Regional Cerebral Perfusion and Cognitive Function are Lower in Type 2 Diabetes with Obesity Mohamad Elsharydah, Anujit Saha, Jeffrey Schaffert, Jack Kaufman, Jennine Leary, Alison Jin, Jaime Almandoz, Binu Thomas University of Texas Southwestern Medical Center, Dallas, United States of America Impact: Regional hypoperfusion in Type 2 Diabetes overlapped with regions implicated in Alzheimer’s disease (AD). Treatment with novel tirzepatide, a dual GIP/GLP-1 receptor agonist, likely reduces AD risk by increasing perfusion to the precuneus and neighboring posterior regions, thereby improving cognition.
		468-02-005. Genetic Underpinnings of Cortical Volume Changes in Type 2 Diabetes: An Integrative Transcriptional and Neuroimaging Analysis Xue Zhang, Jing Zhang Lanzhou University Second Hospital, Lanzhou, China Impact: This study identified underlying risk genes associated with cerebral cortex volume (CCV) alternations in T2DM by conducting a transcription-neuroimaging association study, which provide insight into genetic underpinnings for CCV change in T2DM.
		468-02-006. MRI Volumetric Assessment of Brain Subcortical Deep Grey Nuclei in Type I and Type 2 Diabetes Using Normative Modeling Mohammed Salman Shazeeb, manojkumar saranathan, Hanan Al-Awadhi, Ahmad Awwad, Arit Banerjee, Batool Alesmaeel, Husain Alsaraf, Anant Mashankar, Dalal Alsaeed, Ebaa Alozairi, Abdulla Alozairi University of Massachusetts Chan Medical School, Worcester, United States of America Impact: Alterations in deep grey matter nuclei in Type 1 and Type 2 diabetes offer critical insight into disease-related neurodegeneration. Using normative models enhances sensitivity to subtle volumetric deviations, providing a powerful approach to detect and monitor diabetes-associated brain changes.
		468-02-007. Effects of Aging and Type 2 Diabetes on Neurovascular Coupling to Visual Stimulation Yakun Zhang, Shichun Chen, Kyle Sporn, Daniel Tso, Weiying Dai The State University of New York at Binghamton, Binghamton, United States of America Impact: This study demonstrates that healthy aging reduces HRF peak amplitude in the visual cortex, while type 2 diabetes further alters HRF duration, highlighting distinct and additive impairments in neurovascular coupling, with implications for understanding neurovascular contributions to cognitive deficits.
		468-02-008. Neuroanatomical Subtypes in Type 2 Diabetes Mellitus Reveal Cortical Heterogeneity with Cognitive and Metabolic Dysfunction Xiaomei Yue, Shijun Qiu Guangzhou university of chinese medicine, Guangzhou, China Impact: This study delineates neuroanatomical heterogeneity in type 2 diabetes mellitus (T2DM), demonstrating subtype-specific cortical morphometric similarity network (MSN) alterations associated with cognition and metabolism. These findings advance understanding of T2DM-related brain heterogeneity and may inform future personalized interventions.
		468-02-009. Preliminary Study on Left Ventricular Myocardial Microcirculatory Perfusion in Type 2 Diabetes Mellitus Using IVIM Imaging QING JUN ZHONG, YING WANG, KAI FENG, yang xin, Chen Zhang, YUE Ma Shengjing Hospital of China Medical University, Shenyang, China Impact: Among patients with Type 2 Diabetes Mellitus (T2DM),myocardial microcirculatory dysfunction manifests prior to overt cardiac structural or functional abnormalities, with severity correlating significantly with diabetes duration and glycemic control.IVIM imaging enables detection of these early pathological alterations.
		468-02-010. The decrease of CMRO2 was associated with depression severity in Parkinson’s disease with type-2 diabetes mellitus Zeng Wei, Weiling Cheng, Jiankun Dai, Fuqing Zhou The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China Impact: For the first time, our study showed CMRO₂ change was associated with depression in PDDM patients. Our study may shed light on why PDDM tends to have more severe depression symptom than PDND.
		468-02-011. Evidence of Early Cerebrovascular Dysfunction in Youth-Onset Type 2 Diabetes Amy Shah, Ryan Brady, Shena Rusk, Mekibib Altaye, Dean Beebe, Mark DiFrancesco Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America Impact: This study provides evidence that, even in adolesence, Type-2 diabetes leads to degradation of both peripheral and brain vasculature. Furthermore, the cerebrovascular impact of diabetes extends beyond detrimental effects of obesity. This may impact treatment strategies for pediatric-onset diabetes.
		468-02-012. Assessment of Lower-Limb Muscle Elasticity and Viscosity in Type 2 Diabetes Using Magnetic Resonance Elastography zilong Li, Pinzhen Chen, Xinyu Zhang, Fengwei Yu, Zhiming Zhen, MIN HE, Yi-Cheng Hsu, Wei Chen Army Medical University (Third Military Medical University), Chongqing, China Impact: MRE enables noninvasive quantification of muscle stiffness alterations in diabetic neuropathy. Muscle elasticity/viscosity show promise for early detection, risk stratification, and longitudinal monitoring of DPN.
		468-02-013. Association between skeletal muscle metabolic characteristics and frailty score in patients with type 2 diabetes mellitus Bowen Wang, Yunning Luo, Liping Zuo, Jinlei Fan, Jiaxiang xin, Dexin Yu Qilu Hospital of Shandong University, Jinan, China Impact: This study identifies elevated muscle lipids as a key frailty biomarker in type 2 diabetes, enabling earlier detection. It provides clinicians a potential tool for risk stratification and prompts research into mechanisms linking metabolism to muscle function decline.
		468-02-014. Conventional MRI Combined with Elastography for Assessing Muscle Strength in Type 2 Diabetes Mellitus Kai Huang, Bo He, Meining Chen The First Affiliated Hospital of Kunming Medical University, Kunming, China Impact: This study demonstrates that MRE can noninvasively assess muscle strength in patients with diabetes, providing new insights into muscle functional impairment and laying the groundwork for investigating the role of biomechanical properties in diabetes and developing targeted interventions.
		468-02-015. Morphometric Inverse Divergence Network from structural MRI to Predict Cognitive Decline in Diabetes Yiwen Bao, Daming Shen, Yu Zhou, Dongfeng Wei, Yaqing Ji, Yuanyuan Liu, Lili Guo The Affiliated Huai’an No.1 People's Hospital of Nanjing Medical University, Huai'an, China Impact: This study demonstrates that the MIND network can predict cognitive decline in diabetes, enabling early identification of at-risk individuals for timely intervention and improved patient management.