Advances in Chemical Exchange MRI: CEST, APT, and NOE II
Digital Poster
Contrast Mechanisms
Thursday, 14 May 2026
This session presents emerging applications enabled by advances in CEST, APT, and NOE imaging.
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662-02-001.
Virtual scanner: a deep generalized signal predictor for fast semisolid MT and CEST imaging from compressed MR fingerprinting
Impact: The proposed SPINet functions as a virtual
scanner, enabling rapid, accurate quantitative MTC and CEST imaging from highly compressed
acquisitions, thereby expanding
the clinical and research applications of MRF, and unlocking ultra-rapid
multi-dynamic imaging and AI-driven imaging protocol design.
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662-02-002.
Novel MR Imaging Methods for Quantification of Brain Lipids
Impact: This study establishes tNOE
as a repeatable and lipid-specific MR imaging method, enabling reliable
non-invasive assessment of brain lipid and myelin integrity for early detection
and monitoring of neurodegenerative and demyelinating diseases.
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662-02-003.
Blood Flow Significantly Distorts Measurement Stability and Recovery Kinetics in Single-Voxel Spectroscopy CrCEST
Impact: Avoiding blood
vessels is essential for reliable single-voxel spectroscopy CrCEST measurements
in skeletal muscle, particularly for metabolic studies requiring stable
baseline measurements and accurate recovery kinetics assessment.
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662-02-004.
Reference-locked Evaluation of HyperCEST MRI for Reliable Depolarization Quantification
Impact: HyperCEST MRI suffers from fluctuations in hyperpolarized Xe delivery and inaccurate normalization impairs the analysis of weak CEST responses. Here, we present a method that circumvents normalization and delivers reliable quantitative information even for rather unstable baselines.
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662-02-005.
Lorentzian-Optimized Frequency-Offset-Dependent Sampling for Accelerated CEST MRI
Impact: Our
findings show that Lorentzian-optimized frequency-offset-dependent (LFOD)
sampling can improve CEST image reconstruction by incorporating
metabolite-specific spectral information into k-space design. This reduces artifacts and enables higher acceleration
with total variation regularization, allowing efficient and clinically applicable CEST imaging
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662-02-006.
Overcoming the Limitations of Multi-Compartment Models: A Single-Compartment Phantom for Brain CEST MRI
Impact: This study introduces a novel single-compartment phantom designed to optimize brain CEST MRI protocols. The phantom developed in
this project is the first of its kind facilitating cross-site reproducibility and pawing the way to further CEST MRI phantom research.
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662-02-007.
A Compact 3D-printed Platform with Self-driven Delivery of Hyperpolarized Xenon for HyperCEST MRI Translation
Impact: This
phantom will provide a versatile testing platform to investigate the formation
of localized HyperCEST MRI contrast. It will enable the optimization of HyperCEST
MRI and therefore prepare the next step towards the translation of this method into
(pre-)clinical applications.
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662-02-008.
Proton exchange rate (kₑₓ) in CEST MRI as a surrogate imaging marker for hydroxyl radicals validated in a small metabolite
Impact: This
study validates ROS-induced proton exchange (kₑₓ)
enhancement via oxidation-catalyzed mechanisms in small metabolite phantoms and
establishes endogenous kₑₓ MRI as a quantitative imaging marker for hydroxyl ROS mapping in tissues.
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662-02-009.
In Vitro Characterization of a R3-Noria-methanesulfonate Cage Variant Featuring Promising Biocompatibility for HyperCEST MRI
Impact: The development of biocompatible MRI agents is
constrained by the demand for high imaging sensitivity. This study presents a
modified R3-Noria-methanesulfonate cage designed to
improve biocompatibility while maintaining a strong HyperCEST response,
providing a promising foundation for advanced molecular imaging.
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662-02-010.
Age-related alterations in multiparametric exchange protons in human brain using CEST and Z-spectrum analysis proton (ZAP)
Impact: Observing macromolecular
exchange protons by CEST and ZAP may provide the presence of characteristic
irregular tissues that are not possible to observe in regular MRI images. This
suggests a potential biomarker related to age-associated changes in the brain.
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662-02-011.
CrCEST Measures OXPHOS Improvement and Creatine Decrease following GLP-1 induced weight loss at 7T with 1H-MRS
Impact: CrCEST
and Dixon MRI provide complementary insights into metabolic adaptations of
skeletal muscle during GLP-1 RA therapy, revealing improved energetics despite
modest lean mass reduction.
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662-02-012.
Prediction of pathological complete response to neoadjuvant chemotherapy in breast cancer using APTw imaging
Impact: The combined model of APTWI and HER2 expression status can further significantly improve the diagnostic efficacy.
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662-02-013.
APT subregion Histogram analysis for quantitative Prediction of BRAF mutation and prognostic stratification in rectal cancer
Impact: Identifying BRAF mutation’s association with poorer 2-year DFS and validating our nomogram score as an independent DFS predictor, this study enables risk-adapted, timely intensification or alternative regimens, minimizing unnecessary toxicity, improving survival, and operationalizing personalized treatment planning with actionable stratification.
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662-02-014.
Pretreatment Amide Proton Transfer Imaging for Predicting the Efficacy of Induction Chemotherapy in Nasopharyngeal Carcinoma
Impact: The proposed APT-radiomics model shows
promise for individualized prediction of IC response prior to therapy,
providing an imaging basis for precise treatment decision-making in NPC.
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