Diffusion: DWI/DTI/DKI
Digital Poster
Diffusion
Thursday, 14 May 2026
This session showcases diffusion MRI methods and applications throughout the body using diffusion tensor imaging (DTI), diffusion-weighted imaging (DWI) and diffusion kurtosis imaging (DKI).
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663-02-001.
PSMD revealed brain-wide white matter damage was associated with cognitive impairment in patients with narcolepsy type 1
Impact: Our study indicated the damage of brain-wide
white-matter microstructure was associated with mild cognition impairment in
NT1 patients. This provides a potential target for early intervention and
treatment of NT1-MCI patients.
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663-02-002.
Kurtosis time-dependence in an animal model of neuroinflammation
Impact: Diffusion
time-dependent kurtosis probed to be a sensitive approach for characterising the
effects of different diffusion microenvironments, reflecting an increased
cellular complexity and potentially altered water-exchange dynamics associated
with acute neuroinflammatory responses, thereby indicating its potential
utility as a biomarker.
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663-02-003.
Free water fraction as neuroinflammatory biomarker in chronic pain using NODDI
Impact: This study demonstrates that compartment-specific diffusion modeling reveals neuroinflammatory signatures in chronic pain invisible to conventional DTI, providing the first objective biomarker for pain severity that could guide targeted anti-inflammatory interventions and treatment monitoring.
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663-02-004.
A Zero-Shot SSL Framework for Joint Image Reconstruction and Biomarker Estimation in 2D/3D Under-Sampled MUSE-DTI
Impact: This framework enables the simultaneous reconstruction of DW-images and estimation of DTI-biomarkers within a clinically feasible acquisition time, without requiring fully-sampled ground truths for supervision. This advancement provides an efficient tool for high-fidelity, high-resolution DTI, thereby advancing clinical investigation.
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663-02-005.
Uncovering hidden white matter changes using free water corrected DTI in a 3-month migraine clinical trial with fremanezumab
Impact: The use of the
free water volume fraction combined with free water corrected DTI metrics opens
up the assessment of white matter longitudinal structural changes associated
with specific and distinct pathophysiological mechanisms linked to positive and
negative response to treatment.
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663-02-006.
Perivascular Microstructure After AML Chemotherapy: Associations with Cognitive Outcomes
Impact: perivascular microenvironments alterations may underlie cognitive deficits in Post-chemotherapy AML patients. The DTI-ALPS index and BG-PVS volume represent potential neuroimaging biomarkers, reflecting the occurrence of cognitive impairment following AML chemotherapy.
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663-02-007.
Dynamic diffusion-weighted imaging reveals compromised paravascular pulsatility in alzheimer’s disease mice at 9.4T
Impact: This study provides
in vivo evidence of compromised PVS CSF pulsatility in AD, establishing dDWI as
a promising biomarker of glymphatic dysfunction in neurodegenerative disease
models.
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663-02-008.
Microstructural Alterations in Catecholamine-Mediated Cardiomyopathy with Cardic Diffusion Tensor Imaging: An Initial Study
Impact: Our findings highlight the potential of cDTI in the early detection of cardiomyocyte disorganization, thereby enhancing the role of CMR in the noninvasive myocardial tissue characterization of PPGL.
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663-02-009.
Automated DWI analysis for individualized prediction of malignant cerebral edema after acute ischemic stroke
Impact: Automated diffusion-weighted imaging analysis integrating lesion and anatomical metrics provides accurate, individualized prediction of malignant cerebral edema after acute ischemic stroke, potentially improving early triage and surgical decision-making beyond conventional infarct-volume criteria.
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663-02-010.
Unsupervised learning on AMURA diffusion metrics for white matter characterization in migraine clinical subgroups
Impact: The
combination of AMURA metrics and unsupervised learning enables the
identification of white matter alterations in neurological disorders, revealing
distinct clinical phenotypes and structural patterns associated with disease
chronification and disease features within a clinically feasible single-shell diffusion
MRI acquisition.
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663-02-011.
The effect of T1-weighted MRI guidance on domain randomized Image Quality Transfer of DTI
Impact: Guidance
from structural T1-weighted images can help improve the resolution of diffusion
MRI by Image Quality Transfer with domain randomisation. This could provide
high-quality data in conditions where it would be otherwise challenging,
with more flexibility regarding input resolution.
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663-02-012.
Effect of Age and Sex on DTI-ALPS in Healthy Adults
Impact: Diffusion
tensor image analysis along the perivascular space (DTI-ALPS) is a potentially
useful biomarker for glymphatic function. To improve validation of this
biomarker we need to verify changes with age and sex in healthy adults.
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663-02-013.
Evaluation of leg muscle fasciculations in in healthy volunteers using diffusion tensor imaging (DTI)
Impact:
Our study establishes MRI reference values for fasciculation characteristics, which depend on sex, age, and recent physical activity but not on BMI or LBM, and supports the role of fasciculations as a robust, non-invasive DTI biomarker for early ALS detection. |
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663-02-014.
Microstructural MRI of the fetal brain: preliminary observations from in utero DTI and magnetization transfer imaging
Impact: This study demonstrates feasibility of a developed in-utero MT-weighted sequence for assessing fetal brain microstructure. White matter MTw signal correlated with NICU admission while DTI metrics correlated with postnatal development, suggesting complementary contrast mechanisms for non-invasive investigation of neurodevelopmental complications.
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