Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

Neurodegenerative Diseases

Digital Poster

Neuro A

Tuesday, 12 May 2026

Digital Posters Row E

13:40 - 14:35

Session Number: 464-03

No CME/CE Credit

Similar Sessions

This digital poster session covers MRI methods in a wide range of neurodegenerative diseases, from established methods to leading-edge approaches

		464-03-001. Fiber-Selective Degeneration in Huntington’s Disease Revealed by Integrated NODDI and Fixel-Based Analyses Zexi Wang, Zheng Zhou, Francesco Sanvito, Jingwen Yao David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America Impact: This study reveals selective crossing-fiber degeneration in HD, particularly within the post-thalamic region of the left posterior limb of the internal capsule (PLIC), highlighting potential early biomarkers of WM disruption and disease progression.
		464-03-002. Compensatory Reorganization of Superior Parietal Lobule Networks in ALS: A Longitudinal Resting-State fMRI Study Sadegh Ghaderi, Sana Mohammadi, Sanjay Kalra, Seyed Amir Hossein Batouli Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of) Impact: This study provides longitudinal fMRI evidence for dynamic, compensatory reorganization in the superior parietal lobule networks of ALS patients. This highlights brain plasticity in response to neurodegeneration, suggesting new potential biomarkers.
		464-03-003. Stiff Person Syndrome Spectrum Disorders: A Multi-slice MR Spectroscopic Imaging Study Dillip K. Senapati, Scott D. Newsome, Hanyeh Afshar, Helge Zöllner, Peter Barker, Doris Lin Russell H. Morgan Department of Radiology & Radiological Science, Baltimore, United States of America Impact: This pilot study suggests that MRSI may provide new insights into the underlying pathophysiology of brain involvement in SPSD, in particular suggesting decreased levels of both GABA and glutamate.
		464-03-004. Probing altered cerebral 13C pyruvate metabolism in Amyotrophic Lateral Sclerosis Alixander Khan, Mia Heintzelmann, Esben Hansen, Nikolaj Bøgh, Nichlas Vous Christensen, Michael Væggemose, Lotte Bonde Bertelsen, Jakob Bilcher, Christoffer Laustsen Aarhus University, Aarhus, Denmark Impact: This study demonstrates that hyperpolarised [1-¹³C] pyruvate MRI can measure neurodegeneration related changes showing reduced ¹³Clactate production and changes to dynamics of ¹³Cpyruvatein ALS patients.
		464-03-005. Gray matter atrophy and its neurotransmitter profiles in SCA3: a cerebellar atlas-based correlation analysis Bing Liu, Linwei Zhang Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, China Impact: This study primarily investigated cerebellar structural–neurotransmitter associations in SCA3. Elucidating the neurotransmitter systems contributing to cerebellar vulnerability may help link macroscopic atrophy to underlying neurochemical mechanisms and support the development of targeted interventions.
		464-03-006. Region Specific Deep Gray Matter Iron Dysregulation Mediates Cognitive Impairment in Type 2 Diabetes Kun Wang, Jiahe Wang, Ziyu Diao, Hao dong Qin, Shijun Qiu, Jie An Guangzhou university of chinese medicine, Guangzhou, China Impact: QSM reveals region-specific brain iron dysregulation as a novel biomarker linking T2DM to cognitive decline, providing mechanistic insights that could guide neuroprotective interventions and enable early detection of diabetes-related neurodegeneration
		464-03-007. Whole Brain Metabolites Changes in Adults with Obstructive Sleep Apnea Kamal Singh, Anshita Singh, Diana Kosoyan, Dineth Karunamuni, Ravi Aysola, Sulaiman Sheriff, Andrew Maudsley, Rajesh Kumar David Geffen School of Medicine at UCLA, Los Angeles, United States of America Impact: We observed altered regional brain crucial metabolites in OSA adults, which have never been studied before across the whole-brain, and have implication in identifying interventions and improving the morbidity, mortality, and quality of life in the condition.
		464-03-008. Lower cerebral oxygen utilization associates with poorer cognitive and motor function in progressive supranuclear palsy Na Wang, Pu-Yeh Wu, Xueling Liu Huashan Hospital, Fudan University, China Impact: Reduced subcortical OEF and CMRO₂ in PSP correlate with worse cognition and motor scores. These oxygen-metabolism metrics demonstrate strong diagnostic performance and may serve as imaging biomarkers for distinguishing PSP from HC.
		464-03-009. Basal Ganglia and Thalamic Structural Disconnection in Hereditary Spastic Paraplegia Type 4: A Diffusion MRI Connectome Study Francesca Punzetti, Alessia Quinzi, Magali Jane Rochat, Gianfranco Vornetti, Giovanni Rizzo, Veria Vacchiano, Rocco Liguori, Raffaele Lodi, Caterina Tonon IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy Impact: Structural connectomics reveals distinct basal ganglia and thalamic disconnection patterns in HSP compared to ALS, offering insights into disease-specific pathophysiology and clinical correlates. These findings enhance our understanding of subcortical network involvement and support future clinical and translational applications.
		464-03-010. Multimodal MRI and Machine Learning Uncover Distinct Progression Patterns in Friedreich Ataxia Susmita Saha, Nellie Georgiou-Karistianis, Vivienne Teo, Lachlan Strike, Thiago Rezende, Ian Harding School of Psychological Sciences, The Turner Institute for Brain and Mental Health, Monash University, Clayton, Australia, Australia Impact: This study identifies novel multimodal MRI-based progression subtypes in FRDA using machine learning. Recognising heterogeneity in progression patterns can improve clinical-trial stratification, personalised disease monitoring, targeted therapeutic strategies, and the development of multimodal biomarkers across diverse patient populations.
		464-03-011. Abnormal brain dynamic functional changes in amyotrophic lateral sclerosis Xinyi Yu, Haining Li, Qiuli Zhang, Shan Wu, Tao Lu, Qianqian Duan, Fangfang Hu, Jiaoting Jin, Yi Chen, Ming Zhang The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China Impact: From the perspective of dynamic brain characteristics, a decline in brain function and a compensatory role of the cerebellum have been observed in ALS.
		464-03-012. 3D MR fingerprinting derived quantitative T1 and T2 relaxation maps show abnormalities in ALS Xuemei Huang, Ajay Nemani, Jacqueline Chen, Matt Kiczek, Rebecca Kuenzler, Yuebing Li, Mark Lowe, Stephen Jones Cleveland Clinic Imaging Institute, Cleveland, United States of America Impact: MR fingerprinting derived T1 and T2 relaxation maps in patients with ALS reveals multifocal WM abnormalities suggestive of different disease stages in different brain regions and supporting the use of multimodal MRI to quantify severity and extent of disease progression.
		464-03-013. Sex Differences in DMN Connectivity in Aging Are Independent of Vascular Lesion Burden and Cognitive Status. Soetkin Beun, Patricia Clement, Ernst Rietzschel, Eric Achten Ghent University, Ghent, Belgium Impact: Men show reliably stronger posterior DMN connectivity than women in aging, and this effect persists after controlling for vascular lesion burden and memory performance. Age effects alone are minimal, and no significant trajectory differences in DMN where found.
		464-03-014. Patient-specific 7 Tesla MRI connectivity improves deep brain stimulation for Parkinson’s disease Yarit Wiggerts, Wietske van der Zwaag, P. Richard Schuurman, Maarten Bot Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands Impact: In this prospective study, we use 7T MRI tractography to target the subthalamic motor network for DBS in Parkinson's disease. This patient-specific connectivity analysis provided an individual biomarker guiding electrode placement, increasing DBS effectiveness compared to conventional approaches.