Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Cerebral Small Vessel Disease: Network, Glymphatic, and Blood Flow

Cerebral Small Vessel Disease: Network, Glymphatic, and Blood Flow

Digital Poster

Neuro A

Thursday, 14 May 2026

Digital Posters Row D

14:35 - 15:30

Session Number: 663-04

No CME/CE Credit

Similar Sessions

This session highlights the pathophysiology of cerebral small vessel disease, including cerebral amyloid angiopathy, using a range of imaging modalities; topics include functional-structural network analysis and diffusion-based index of glymphatic function.

Skill Level: Intermediate

		663-04-001. A Prospective Registered Study to Validate Coupled Structural-Functional Network Disruption in CSVD Chen Zhang, Chenchen Han, Xiaoyan Han, Pang Du, Lihao Xiao Xi'an Daxing Hospital affiliated to Yan'an University, Xi'An, China Impact: This study will rigorously validate multimodal MRI biomarkers for CSVD. If successful, this will provide robust targets (e.g., insular function, GCC integrity) for future clinical trials and understanding disease progression.
		663-04-002. Altered brain structural-functional coupling driven by total cerebral small-vessel disease burden Tianqi Wang, jianxiu lian, Wei Wang The First Affiliated Hospital of Harbin Medical University, Harbin, China Impact: CSVD progression disrupts nodal structure–function coupling, offering a potential imaging biomarker for early detection.
		663-04-003. Exploring the impact of white matter hyperintensity on structural and functional networks in cerebral small vessel disease Jiayu Fang, Di Wu, Zuwu Ai, Junxiong Xie, Jialu Zhang, Yaqin Zhang The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China Impact: Parameters reflecting structural and functional networks through multimodal MRI help us understand the changes in cerebral small vessel disease. It might non-invasively reflect the progression and prognosis of disease, guide personalized treatment and potentially improve the quality of life.
		663-04-004. The Association of 5.0 Tesla MRI-based Comprehensive CSVD Burden Scoring with Glymphatic Function Impairment Tengfei Song, Pan Wang, Jing Yang, Hai Lin, Lixin Du Shenzhen Longhua District Central Hospital, Shenzhen, China Impact: This study provides the first evidence linking comprehensive 5T MRI-based CSVD burden scoring to impaired glymphatic function, offering a novel imaging framework to understand the role of glymphatic clearance in CSVD pathophysiology.
		663-04-005. Small vessel morphology affects the temporal sequence of white matter free water and DTI-ALPS in CADASIL Xuejia Jia, Jiajia Zhang, Yingying Li, Chen Zhang, Xiuqin Jia, Qi Yang Beijing Chao-Yang Hospital, Beijing, China Impact: This study addressed critical gaps in understanding how vascular morphology triggered glymphatic dysfunction and cognitive decline in CADASIL. By validating CSF-ISF pathway and linking arterial structure to clearance dysfunction, our findings offered novel therapeutic targets to decrease cognitive impairment risk.
		663-04-006. DTI revealed microstructure damage in WMH-P was associated with further cognitive decline one year later in CSVD patients Weisen Wang, Yunheng Li, Xinyuan Zhang, Jiankun Dai, Wenjia Peng, Hao Li, Xiaoying Bi the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China Impact: Our study investigated the relationship between microstructural damage in white-matter hyperintensity penumbra and cognitive dysfunction in patients with CSVD and established a link between early white matter damage and further cognitive decline one year later.
		663-04-007. Characterization of White Matter Hyperintensities and Penumbras across Different Fazekas Scales xin wang, Yue-Qing Yang, De-Yu Gao, Ben Wang, Li-Na Feng, Su-Jie Wang, Min-Ying Su, Yu Wang University of California, Irvine, United States of America Impact: The study found a link between WMH severity and cardiovascular risk factors, CSVD markers, and lymphatic function, suggesting WMH heterogeneity through varying penumbra extents, which may serve as an early intervention target.
		663-04-008. Myelin-driven structural network redundancy underlies cognitive function in cerebral small vessel disease Yage Qiu, Wentao Hu, Yao Wang, Qingyang Fu, Ying Hu, Qun Xu, Hongjiang Wei, Yan Zhou, Yawen Sun Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China Impact: This study highlights the role of normal-appearing white matter (NAWM) myelin in preserving cognition via structural network redundancy in cerebral small vessel disease (CSVD), offering biomarkers for early intervention and prompting research into myelin-targeted therapies.
		663-04-009. Hippocampal Blood Flow Reserve Associated with Cognitive Function and Structural Integrity in Cerebral Small Vessel Disease Binglan Li, Lisha Nie, Li yongmei The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Impact: The relationship between hippocampal blood flow impairment and structural integrity as well as cognition in small vessel disease has been observed. This may support early vascular interventions targeting hippocampal blood flow and provide multimodal imaging biomarkers for early disease monitoring.
		663-04-010. IVIM and Cerebrovascular Reactivity MRI reveal early microvascular dysfunction surrounding White Matter Hyperintensities Lena Schmitzer, Maurizio Bergamino, Ashley Stokes, Tim Bitter, Kilian Weiss, Jannis Bodden, Jan Kirschke, Christine Preibisch, Jens Göttler, Stephan Kaczmarz, Gabriel Hoffmann TUM School of Medicine and Health, TUM University Hospital Rechts der Isar, Munich, Germany Impact: This study demonstrates that microvascular alterations may be present in perilesional white matter before visible lesion expansion and proposes detection by contrast-agent-free MRI. The combined vascular biomarkers offer opportunities for risk stratification and mechanistic investigation of small vessel disease progression.
		663-04-011. Atlas-Based Analysis of Quantitative 7T MRI Reveals Microstructural Patterns in Cerebral Small Vessel Disease Subtypes Ian Cherabier, Gian Franco Piredda, Gabriele Bonanno, David Seiffge, Jonathan Disselhorst, Bénédicte Maréchal, Piotr Radojewski, Tom Hilbert, Martina Goeldlin Siemens Healthineers International AG, Lausanne, Switzerland Impact: This study is among the first to investigate T1 alterations associated with distinct types of cerebral small vessel disease. The findings indicate that quantitative imaging techniques may facilitate more accurate diagnosis in the future.
		663-04-012. Iron Dysregulation in Cerebral Small Vessel Disease: A Quantitative Susceptibility Mapping Study Revealing Spatial Patterns a Pengcheng Liang, Meng Li, Jing Li, Lingfei Guo, Changhu Liang Impact: Iron dysregulation alterations within WMH provide independent information about cognitive risk in CSVD. QSM emerges as a promising biomarker for monitoring cognitive trajectory and facilitating early identification of patients at risk for cognitive decline.
		663-04-013. Clustering of Cerebral Microbleeds in Cerebral Amyloid Angiopathy: A Flow Territory-Based Analysis Manon Schipper, Reinier GJ van der Zwet, Jelle Goeman, Thijs van Harten, Emma Koemans, Marieke Wermer, Marianne AA van Walderveen, Matthias van Osch Leiden University Medical Center, Leiden, Netherlands Impact: Clustering of cerebral microbleeds with inter-individual variability in Cerebral Amyloid Angiopathy indicates localized pathology and resulting inflammation, vascular anatomy, or disease progression. These insights help to increase our understanding of the development of cerebral microbleeds and localized progression of pathology.