Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Imaging the Brain’s Microenvironment: From Glymphatics to Cognition

Imaging the Brain’s Microenvironment: From Glymphatics to Cognition

Digital Poster

Neuro A

Tuesday, 12 May 2026

Digital Posters Row A

16:55 - 17:50

Session Number: 460-06

No CME/CE Credit

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This digital poster session explores how advanced neuroimaging can characterize the brain’s microenvironment and its relationship to cognition, aging, and neurological disease. Presentations span functional connectivity, diffusion microstructure, myelin and iron imaging, blood–brain barrier permeability, and emerging measures of glymphatic and perivascular transport. Studies include both human and animal models across conditions such as Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, sleep disorders, vascular cognitive impairment, and systemic disease. Collectively, the session highlights how quantitative imaging biomarkers can reveal mechanisms of brain clearance, tissue integrity, and network disruption underlying cognitive dysfunction.

		460-06-001. Functional Connectivity and Cognitive Functions: Age-Related Variations in Resting State fMRI Arman Deep Singh, Mukesh Kumar, Swathi BH, Bhargavi P, Apurva Awasthi, Ashwini Godbole, Subash Khushu The University of Trans-Disciplinary Health Sciences and Technology, Bengaluru, India Impact: The study enhances understanding of how aging affects functional connectivity and cognition, providing valuable insights into neural mechanisms underlying age-related decline. The findings may support early identification of cognitive changes and inform interventions aimed at promoting healthy brain aging.
		460-06-002. Choroid plexus volume in Alzheimer’s disease genetic risk: an early marker of glymphatic dysfunction? Hannah Chandler, Natalie Jones, Neil Harrison, Kevin Murphy, Thomas Lancaster Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom Impact: We reveal a mechanistically coherent link between AD-PRS and CP volume, supporting the notion that cell-type-informed genetic analysis can reveal tissue-specific effects of AD-related PRS. T1 derived CP volume, may have utility for detecting brain pathophysiology in early AD.
		460-06-003. Myelin Alteration in the Corpus Callosum of 5xFAD Mice revealed by quantitative T2 and myelin water imaging Hwapyeong Cho, SoHyun Han, Youngkyu Song, HyungJoon Cho, Jee-Hyun Cho Korea Basic Science Institute, Cheongju, Korea, Republic of Impact: Region-specific myelin imaging in an AD mouse model reveals early white matter damage undetected by structural MRI. These biomarkers enable tracking disease progression and assessing therapies targeting myelin preservation, supporting earlier intervention and improving translation toward more precise patient care.
		460-06-004. Automated Segmentation of Individual Cerebral Perfusion Territories from Vessel-Selective MRI by Deep Learning Vincent Wohlfarth, Nico Sollmann, Matthias Toth, Michael Helle, Jan Kirschke, Stephan Kaczmarz, Julia Schnabel, Christine Preibisch, Hannah Eichhorn, Gabriel Hoffmann TUM University Hospital, Munich, Germany Impact: Automated nnU-Net-based segmentation facilitates accurate and consistent perfusion territory mapping from superselective arterial spin labelling (ssASL), by reducing manual effort and observer bias. This scalable, data-driven approach may enable clinical assessment of collateral blood flow, e.g., in cerebrovascular diseases.
		460-06-005. Higher Body Mass Index Associated with More Efficient Functional Brain Networks in Midlife World Trade Center Responders Xinlan Zhang, Jia Ying, Tianyun Zhao, Sean Clouston, Benjamin Luft, Chuan Huang Emory University, Atlanta, United States of America Impact: Findings indicate that BMI modulates functional brain network topology, particularly among cognitively impaired responders. This supports links between systemic metabolic health and neural efficiency, highlighting BMI as a potential modifiable factor in maintaining midlife cognitive function after environmental exposure.
		460-06-006. Strategic White Matter locations for cognitive impairment in ESRD patients QIANGE ZHU, YIFAN CUI, Zhaoyao Luo, Junya Mu, Shaohui Ma, Tao Lu, Guangxu Han, Ming Zhang The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China Impact: This study identifies the forceps major as a key hub where WMH-related disconnection contributes to cognitive impairment in ESRD. Integrating imaging and transcriptomics provides new insights into network vulnerability and suggests potential molecular targets for early therapeutic intervention.
		460-06-007. Advanced diffusion metrics demonstrate microstructural abnormalities in multiple sclerosis diffusely abnormal white matter Tigris Joseph, Shannon Kolind, Guojun Zhao, Peng Sun, Robert Carruthers, Alice Schabas, Ana-Luiza Sayao, Virginia Devonshire, Roger Tam, G. R. Wayne Moore, David Li, Anthony Traboulsee, Irene Vavasour, Cornelia Laule University of British Columbia, Vancouver, Canada Impact: Advanced diffusion imaging suggests MS diffusely abnormal white matter (DAWM) damage is intermediate between normal appearing white matter and lesions. Our work supports that DAWM is a pathologically distinct type of tissue damage in multiple sclerosis.
		460-06-008. Time-Dependent Diffusion MRI of Neurofluid–Microstructure Coupling in Obstructive Sleep Apnea Toshiaki Taoka, Kunihiro Iwamoto, Rintaro Ito, Seiko Miyata, Rei Nakamichi, Toshiki Nakane, Hiroshige Fujishiro, Masashi Ikeda, Kazushige Ichikawa, Akifumi Kamiunten, 伸保市之瀬, Shinji Naganawa Nagoya University Graduate School of Medicine, Nagoya, Japan Impact: Time-dependent diffusion (ΔOGSE–PGSE) provides a physiology-oriented, noninvasive biomarker linking sleep architecture to neurofluid–microstructure coupling in OSA, complementing glymphatic-proximal MRI indices and informing mechanism-based patient phenotyping and longitudinal treatment monitoring.
		460-06-009. Choroid Plexus Cyst Enlargement Correlates with Lower DTI-ALPS Index in Parkinson’s Disease with Freezing of Gait Suyi Zhou, Zhiming Zhen, Dandan Yuan, Fengwei Yu, Taotao Yang, Siyao Xu, Chenghao Cao, Ying-Hua Chu, Yi-Cheng Hsu, Huilin Pang, zilong Li, Peiyu Huang, Heqing Huang, Wei Chen Army Medical University (Third Military Medical University), Chongqing, China Impact: Choroid plexus cysts were larger and more numerous in Parkinson’s disease with freezing of gait and were linked to a lower DTI-ALPS index. These MRI features may help identify patients with greater mobility problems.
		460-06-010. Effects of Smoking and Asthma on Development of White Matter Hyperintensities and Iron Distribution in the Brain Eamon Doyle, Bethany Sussman, Hashem Zamanian, Ash Rodgers, Matthew Borzage Keck School of Medicine, University of Southern California, Los Angeles, United States of America Impact: This work provides evidence that pulmonary health and injury may play a role in the development of differing patterns of potentially modifiable brain injury.
		460-06-011. Frontoparietal structure-function coupling disruption was associate with cognitive impairment in patients with severe WMH Kaixiao Chen, Lin Wu, Jiankun Dai, Fuqing Zhou The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China Impact: Our findings identified the MRI-derived frontoparietal structure–function coupling index as an independent risk factor for cognitive impairment, linking structure–function coupling disruption to cognitive decline in patients with severe white matter hyperintensities.
		460-06-012. Validation and comparison of experimental measures of glymphatic clearance in the rat brain Ben Leverton, Yolanda Ohene, William Morrey, Ross Little, Juan Sebastian Bermudez, Ben Dickie University of Manchester, Manchester, United Kingdom Impact: This study will compare three MRI methods for assessing glymphatic function, determining their sensitivity to physiological and pharmacological modulation. Findings will guide future development of MRI biomarkers for brain clearance and support future translation of glymphatic imaging into clinical research.
		460-06-013. Magnifying (G)Lymphatics: Insights into Sexual Dimorphism in Brain Clearance Mechanisms. J. Kent Werner, Nastaren Abad, Luca Marinelli, Barbara Bendlin, Maria Greufe, Theresa Kang, Sandy Harding, J. Kevin DeMarco, Steven Kecskemeti, Melanie Boly, Isabelle Heukensfeldt Jansen, Thomas Foo, Chitresh Bhushan, Muhan Shao, Angeliki Pollatou, JoAnn Manson, Sara Tirner, Andrew Alexander Uniformed Services University of the Health Sciences, Bethesda, United States of America Impact: This study enables non-invasive, in-vivo, sleep-dynamic imaging of glymphatic and meningeal lymphatic flow, revealing sexual dimorphism and age related differences. Findings may inform personalized care in Alzheimer’s disease and inspire new research into sleep-dependent brain clearance and neurodegenerative risk factors.
		460-06-014. Robust acquisition of CSF-STREAM at 3 Tesla: Measuring perivascular CSF mobility at clinical field strength Siri Svensson, Emiel Roefs, Nina Fultz, Madda Debiasi, Matthias van Osch, Lydiane Hirschler Department for Physics and Computational Radiology, Oslo University Hospital, Oslo, Norway Impact: We demonstrate that CSF-STREAM, previously limited to 7T, can robustly measure CSF-mobility at 3T. This non-invasive technique is now accessible on clinical MRI systems, enabling investigations of brain clearance in patients with e.g. neurodegenerative diseases.