Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

Neuro Imaging and Metabolism

Flash Presentation

Preclinical

Monday, 11 May 2026

Roof Terrace

08:20 - 10:10

Moderators: Himanshu Singh

Session Number: 331-01

No CME/CE Credit

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Neuro-related MRI/MRS in experimental models of brain health, disease/injuries, and neurotherapeutics, allowing the researchers to present Power Pitch and a Traditional Poster

08:20		331-01-001. Subacute Caudate Putamen Alteration Predicts Long-term Post-Stroke Outcomes Following Intranasal Hericium erinaceus Treatment Ying-Wei Sung, Ting-Lin Tsai, Pei-Chien Hsu, Li-Ya Lee, Chin-Chu Chen, Jia-Jin Chen, Bao-Yu Hsieh, Yi-Hsuan Lee, Yu-Chieh Jill Kao National Yang Ming Chiao Tung University, Taipei, Taiwan Impact: This study identifies early CPu alteration as potential imaging biomarker for predicting long-term stroke outcomes following HEet administration and supports HEet exhibits neuroprotective effects on stroke.
08:22		331-01-002. Differential Vulnerability of Oxidative and Glycolytic Metabolism in ApoE and APP mouse models of Alzheimer’s disease Tamara Vasilkovska, Marina Radoul, Yoshitaka Sei, Lillie Bui, Caroline Guglielmetti, Yadong Huang, Jeremy Gordon, Ken Nakamura, Myriam Chaumeil University Of California, San Francisco (UCSF), United States of America Impact: This study identifies ApoE4-driven, age-dependent oxidative metabolic failure as a key bioenergetic defect in Alzheimer’s models. Using hyperpolarized ¹³C MRI, we reveal sex-specific metabolic resilience and convergent mitochondrial impairment, establishing oxidative metabolism as an early therapeutic target in Alzheimer’s disease.
08:24		331-01-003. Circuit-Specific Motor Restoration by BurstDR Subthalamic Nucleus Deep Brain Stimulation in a Parkinson’s Disease Mouse Model Ting-Chieh Chen, Ssu-Ju Li, Ching-Wen Chang, Yao-Wen Liang, Cheng-Ru Yang, Yu-Qian Ke, Yi-Duan Chen, Yi-Ren Lin, Zhi-Shin Cheng, Sheng-Huang Lin, You-Yin Chen National Yang Ming Chiao Tung University, Taipei, Taiwan Impact: This study demonstrates that BurstDR selectively restores motor function and strengthens motor‑network connectivity in Parkinson’s models, offering a more efficient, circuit‑specific alternative to tonic DBS that targets motor benefit while minimizing limbic off‑target effects.
08:26		331-01-004. Exploring myelin integrity in a mouse model of Huntington's Disease using Inhomogeneous Magnetization Transfer Andrea Estevez Velez, Joëlle van Rijswijk, Johan Van Audekerke, Ignace Van Spilbeeck, Mohit Adhikari, Roger Cachope, Dorian Pustina, Marleen Verhoye, Daniele Bertoglio University of Antwerp, Antwerp, Belgium Impact: This work validates the use of ihMT with T1D filtering as a powerful, non-invasive method for dissecting and localizing distinct sub-pools of macromolecular pathology in the brain, offering greater specificity to myelin than traditional Magnetization Transfer (MT) imaging.
08:28		331-01-005. Impact of radiotherapy on brain growth and neurometabolites in a juvenile rodent model Shannon Helsper, Uwe Himmelreich, Edmond Sterpin KU Leuven, Leuven, Belgium Impact: Longitudinal MRI/S offer insights into how radiotherapy-induced neurotoxicity affects developing brains. In a juvenile rat model, we tracked changes in brain growth and neurometabolites, finding the effects of radiotherapy vary by irradiated region yet manifest as widespread, systemic alterations.
08:30		331-01-006. Multimodal MRI Characterization of Pregnancy-Related Structural and Functional Brain Reorganization in Mice Kavita Singh, Alexandru Korotcov, Marena Kutschman, Temitope Adebayo, Salsabila Purnomuo, Sarah Anisowicz, Maureen Hood, John Wu Uniformed Services University of the Health Sciences, Bethesda, United States of America Impact: This study establishes a mouse model for investigating pregnancy-induced brain remodeling using multimodal MRI, DTI and resting-state fMRI. It advances our understanding of maternal brain plasticity and its relevance to cognitive and emotional health during the postpartum period.
08:32		331-01-007. Mapping cerebrovascular reactivity in awake mice: insights into contrast mechanisms of SORDINO ZTE sequence Hyun Seok Moon, Geun Ho Im, Sung-Ho Lee, Yen-Yu Ian Shih, Seong-Gi Kim Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America Impact: By comparing BOLD-EPI and SORDINO sequences in cerebrovascular reactivity mapping, this study suggests SORDINO as a powerful alternative and reveals blood transit time change as a critical yet underappreciated contributor to SORDINO’s functional contrast.
08:34		331-01-008. Cross-species spatiotemporal axis of arousal from fMRI dynamics Lauren Daley, Wen-Ju Pan, Shella Keilholz Emory/Georgia Tech, Atlanta, United States of America Impact: Both animal and human fMRI studies have resulted in critical contributions to understanding how the brain is organized at rest through network architecture. Establishing how these spatiotemporal networks are altered across wakefulness in humans/mice provides framework for designing/interpretating cross-species studies.
08:36		331-01-009. Strain-dependent binocular integration across temporal frequencies in the rat superior colliculus revealed by high-field fMRI Zijuan Yu, Haoyu Wang, Yan Zhuo, Zhentao Zuo National Key Laboratory of Cognitive Science and Mental Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China Impact: This work reveals strain-dependent binocular integration in rat superior colliculus using high-field fMRI. The results highlight genetic influences on subcortical visual computation and provide foundation for using rat strains as comparative models to dissect binocular processing and visual integration disorders.
08:38		331-01-010. VBM reveals that electroconvulsive therapy increases brain volume linked with synaptic structural changes in depressive mice. Mariateresa Merante, Yoshifumi Abe, Kenji Tanaka Keio University School of Medicine, Tokyo, Japan Impact: By combining mouse MRI and histology, we enabled investigation of the biological mechanisms by which electroconvulsive therapy (ECT) induces structural and synaptic remodeling in the amygdala–thalamus pathway, bridging clinical observations with mechanistic insight into antidepressant effects.
08:40		331-01-011. Direction-Specific DTI Changes in Motor Cortex After Sparse Ablation of Intratelencephalic Pyramidal Neurons Emma Thomson, Mihai Atudorei, Hartwig Siebner, Mattias Rickhag, Tim Dyrby Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Copenhagen, Denmark Impact: Early cortical neurodegeneration may involve sparse, neuron-selective loss within preserved tissue. We show that even population-specific, Cre-targeted ablation of excitatory intratelencephalic (IT) neurons produces direction-specific diffusion MRI changes, motivating anisotropy-aware biomarkers for early cortical disease detection.
08:42		331-01-012. Impaired Pentose Phosphate Pathway Flux in Mouse Model of Depression Anant Patel, Pravin Mishra, Ajay Sarawagi, Hilal Roshan CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India Impact: This study provides the first direct evidence of reduced oxidative PPP flux in a depression, advancing understanding of redox homeostasis and offering potential targets for metabolic intervention in mood disorders.
08:44		331-01-013. Social status individualizes brain connectome dynamics to buffer negative hippocampal recall Jonathan Reinwald, Sarah Ghanayem, David Wolf, Danai Nikolantonaki, Markus Sack, Gabriele Ende, Wolfgang Weber-Fahr, Wolfgang Kelsch Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany Impact: These findings establish connectome adaptability as a systems-level mechanism linking everyday social-status experiences to hippocampal control of negative memory. Thereby, we identify a translational endophenotype that connects ecological behavior, network dynamics, and cognitive resilience relevant to depression risk across species.
08:46		331-01-014. Day–Night Differences in Functional Network Connectivity Reflect Circadian Modulation in Awake Mice David Hike, Hyun Seok Moon, Xiaochen Liu, Xiaoqing Zhou, Nivetha Pasupathy, Yuanyuan Jiang, Xin Yu Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America Impact: Circadian phase significantly alters resting-state network dynamics in awake mice, indicating that the “rest-state (day)” reflects distinct intrinsic brain states from the “active-state (night)”. Accounting for circadian timing is therefore essential in designing and interpreting preclinical fMRI experiments.
08:48		331-01-015. Dynamic ¹H MRS at 11.7 T Reveals Minute-Scale Neurochemical Kinetics in Mouse Caudate–Putamen after Lactate Challenge Alireza Abaei, Dinesh Deelchand, Francesco Roselli, Volker Rasche Ulm University, Ulm, Germany Impact: Enables noninvasive, minute-scale readouts of brain neurochemistry during controlled lactate challenge, revealing lactate and glutamate coupling in mouse striatum and supporting tests of energy allocation and astrocyte neuron shuttling for biomarker development and metabolic intervention design.
08:50		331-01-016. Hippocampal Glutamate Alterations in LPS-Induced Neuroinflammation Revealed by GluCEST-weighted Molecular Imaging Do-Wan Lee, Donghoon Lee, Yeon Ji Chae, HyunJu Ryu, Andrea Son, Chul-Woong Woo, Dong-Cheol Woo, Jung-Hyun Choi University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of Impact: GluCEST and ¹H-MRS revealed significant glutamate elevation in LPS-induced neuroinflammation, effectively reduced by dexamethasone. These findings establish molecular MR imaging/spectroscopy as translational biomarkers for detecting neuroinflammatory brain injury and monitoring therapeutic modulation, enabling precision approaches in inflammatory brain disorders.
08:52		331-01-017. Deuterium Labeling Kinetics and Neurometabolic Assessment Using 2H NMR and Indirect Detection by ¹H NMR Spectroscopy Akila Ramesh, Ravinder Reddy, Anant Patel CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India Impact: ²H-labeled substrate infusion, along with ¹H NMR spectroscopy, can be used to measure metabolite turnover indirectly for neurometabolic analysis in neurological conditions. This method is more time-efficient and cost-effective than ¹³C-based measurements.
08:54		331-01-018. Nicotinamide riboside supplementation improves cerebral glucose metabolism in a mouse model of Alzheimer’s disease Anshuman Swain, Narayan Datt Soni, Sunil Khokhar, Bhavya Yendapalli, Dipak Roy, Halvor Juul, Abeer Mathur, RAVI PRAKASH REDDY NANGA, Mohammad Haris, Ravinder Reddy University of Pennsylvania, Philadelphia, United States of America Impact: This study demonstrates an improvement in cerebral glucose metabolism following treatment with nicotinamide riboside (NR) in a mouse model of Alzheimer’s disease (AD), thereby providing information on a potential mechanism of action for NAD⁺ precursors in neurodegeneration.