Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition • 09-14 May 2026

Digital Poster

Large Animals

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Large Animals
Digital Poster
Preclinical
Thursday, 14 May 2026
Digital Posters Row E
09:25 - 10:20
Session Number: 664-02
No CME/CE Credit
Similar Sessions
Magnetic resonance studies in large animals, including the brain, cardiac, etc
  Figure 664-02-001.  Multimodal Neuroimaging Reveals Spatiotemporal Dynamics of Stroke Progression in a Non-Human Primate Model
Ssu-Ju Li, Ching-Wen Chang, Boyi Qu, Yao-Wen Liang, Cheng-Ru Yang, Ting-Chieh Chen, Yu-Qian Ke, Yi-Duan Chen, Yi-Ren Lin, Zhi-Shin Cheng, You-Yin Chen, Hsin-Yi Lai
National Yang Ming Chiao Tung University, Taipei, Taiwan
Impact: This comprehensively characterized aged macaque stroke model with multiparametric profiling provides a validated translational platform for preclinical research, enabling sensitive longitudinal tracking of microstructural injury evolution and supporting future neuroprotective intervention studies.
  Figure 664-02-002.  Dynamic Reorganization of Macaque Brain Networks During Acute Stroke Assessed by Resting-State functional MRI
Qiliang Du, Fuyu MAI, Pengzhan Xu, Xiaodong Zhang
State Key Laboratory of Digital Medical Engineering, Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Sanya, China
Impact: The study revealed the dynamic reorganization of different brain networks during acute stroke, and the findings may have clinical implication for recovery assessment and development of rehabilitation strategies in stroke patients.
  Figure 664-02-003.  Cohesive Developmental Timing in Marmosets Revealed from DTI with Gaussian Process Regression
Stephen Sawiak, Michal Graczyk, Gemma Cockcroft, Lauren McIver, Stacey Gould, Edward Bullmore, Angela Roberts
University of Cambridge, Cambridge, United Kingdom
Impact: High resolution DTI and machine learning predict marmoset age revealing aspects of tight synchrony in white matter connectome development across adolescence; with key predictive connections linking association areas in parietal to those in temporal and prefrontal cortices.
  Figure 664-02-004.  Evaluating lipid-sensitive MRI for mapping lipid composition in the developing marmoset brain
Anshuman Swain, Tianjia Zhu, Ziqin Zhang, Keshav Menon, Narayan Datt Soni, Paul Jacobs, RAVI PRAKASH REDDY NANGA, Mohammad Haris, Hao Huang, Ravinder Reddy
University of Pennsylvania, Philadelphia, United States of America
Impact: This study presents MR lipid biomarkers, such as NOE and FINUTE, that provide insight into lipid homeostasis during marmoset brain maturation and offer diagnostic potential for detecting and monitoring developmental brain disorders.
  Figure 664-02-005.  Age-related brain volumetric changes in a non-human primate model of sporadic cerebral amyloid angiopathy
Muhammad Soliman, Suleiman Khan, Ema Mir, Hugo Cuellar, Charles Kingsley, Jody Swain, Michele Mulholland, William Hopkins, Thomas Wisniewski, Youssef Wadghiri, Jelle Veraart, Henrieta Scholtzova
NYU Grossman School of Medicine, New York, United States of America
Impact: The reported results are the first demonstration of brain volumetric alterations in the SQM model. Our findings underscore the impact that CAA and vascular dysfunction play in brain aging, while highlighting the utility of SQMs to study CAA/AD pathology.
  Figure 664-02-006.  Progressive Changes of Structural and Functional Connectivity in Rhesus Monkey Brains During Acute Stroke
fuyu mai, QIliang Du, Xiaodong Zhang
Hainan University, Sanya, China
Impact: the dynamic evolution of structural and functional connectivity (SC and FC) was examined and illustrated during acute stroke and it may play a key role for assessing post-stroke functional recovery.
  Figure 664-02-007.  Morphological Changes of subcortical regions in the developing brains of a transgenic monkey model of Huntington’s Disease
Rong Wang, Qiliang Du, Pengzhan Xu, Binglei Huang, Yuanshun Chen, Xiaofei Chang, Xiaodong Zhang
State Key Laboratory of Digital Medical Engineering, Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Sanya, China
Impact: 
  1. To advance the understanding of the subcortical degeneration during the development of the brain with Huntington’s Disease
  2. The difference of the subcortical structures in the developing brains may be associated with the CAG repeat length in different neurons
  Figure 664-02-008.  Development of a Perinatal Lamb Brain MRI Template and Atlas for Translational Neurodevelopmental Research
Nina Odgaard, Kelly Payette, Christian Stoeck, Ahmed Hassan, Rajiv Chaturvedi, Michael Seed, Monique Haak, Edgar Jaeggi, Miriam Weisskopf, Walter Knirsch, Andras Jakab
University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland
Impact: This is the first perinatal lamb brain MRI template and atlas created with T2-weighted images of formalin-fixed ovine brains (135 days gestational age). The template and tissue prior maps enable faster, automated workflows in ROI-based translational neurodevelopmental research.
  Figure 664-02-009.  Diffuse visual-pathway injury after blast in sheep: SS3T-CSD and centerline FA profiling at 7T (N=4)
Sudhir Pathak, Devin Raine Everaldo Cortes, Yijen Wu, Christopher Thibault, Jane Manfredi, Ricardo Mejia-Alvarez, Tony Yuan, Walter Schneider
University of Pittsburgh, Pittsburgh, United States of America
Impact: SS3T-CSD plus hemisphere-wise centerline FA profiling detects proximal optic-nerve microstructural change after blast—even when structural MRI is subtle—providing a practical, reproducible pipeline to study mechanisms of progressive visual loss after blast exposure.
  Figure 664-02-010.  Assessing myocardial ischemia-reperfusion injury in a pig model using rotating frame spin-lock MRI methods at 1.5 T
Riku Kiviluoto, Minja Heikkilä, Hanna Wang, Jarkko Kuivalainen, Anni Määttä, Juho Liljeström, Mimmi Liukkonen, Saara Sillanmäki, Minna Husso, Saija Puumalainen, Sanna Tietäväinen, Alexandru Schiopu, Anna-Kaisa Ruotsalainen, Seppo Ylä-Herttuala, Elias Ylä-Herttuala
University of Eastern Finland, Kuopio, Finland
Impact: This work demonstrates that rotating frame MRI methods enable non-invasive determination of myocardial ischemia-reperfusion injury without the need of contrast agents, which improves patient safety and shortens clinical imaging time while providing sensitive characterisation of myocardial changes after ischemic injury.
  Figure 664-02-011.  Design of a stimulator for porcine cardiac stimulation measurements at multiple frequencies
Valerie Klein, Christopher Nguyen, Zi Xiong, Lawrence Wald, Bastien Guerin
Harvard Medical School, Boston, United States of America
Impact: We model cardiac stimulation (CS) in detailed porcine body models to design a device for porcine CS measurements at multiple stimulus frequencies. Those measurements will allow further validation of our modeling and direct measurements of cardiac chronaxie and rheobase.
  Figure 664-02-012.  Feasibility of High Resolution Three-dimensional LGE and DTI for Quantifying Atrial Remodeling in Atrial Fibrillation
George Thornton, Archana Malagi, Ashita Bhatnagar, Jonathan Louis, Lexiaozi Fan, Dima Bishara, KyungPyo Hong, Brandon Benefield, Daniel Lee, Hsin-Jung Yang, Christopher Nguyen, Daniel Kim, Anna Pfenniger, Suvai Gunasekaran
Cedars-Sinai Medical Center, Los Angeles, United States of America
Impact: This pilot study establishes the feasibility of multiparametric MRI to quantify atrial remodeling in a canine AF model and highlights its potential for developing non-invasive MRI biomarkers to guide preclinical therapeutic evaluation.
  Figure 664-02-013.  In-vivo vs. in-vitro characterization of ferumoxytol sensitivity and relative T1 contrast at different field strengths
Hazar Benan Unal, Shahriar Zeynali, Eric Anttila, Rohan Dharmakumar, David Gross, Behzad Sharif
Purdue University, West Lafayette, United States of America
Impact: Our results suggest that 0.55T can offer a reduced cost for ferumoxytol-enhanced MRI compared to 3T. Our in-vivo studies can provide a more reliable guideline for dosing than in-vitro measurements for ferumoxytol, whose clinical use is expected to grow.
  Figure 664-02-014.  Characterizing the effects of novel, formaldehyde-free fixation method on the human brain with in situ relaxometry
David Leonard Asuncion, Kayla Gray, Hahn Soe-Lin, Chris Blais, Marco Santello, Rosalind Sadleir
Arizona State University, Tempe, United States of America
Impact: Preservation of in vivo relaxation properties in cadaveric models using formaldehyde-free fixation methods demonstrates potential as a safer and more realistic testing platform for quantitative MRI research of the human brain.
  Figure 664-02-015.  GABA Increase Revealed during Circulatory Arrest using an Improved MEGA-SPECIAL sequence with Macromolecule Suppression
Meng Gu, Ralph Hurd, Daniel Spielman
Stanford Medicine, Stanford, United States of America
Impact: GABA dynamics has not been investigated during circulatory arrest using J-difference editing MRS. This study revealed GABA increases during circulatory arrest and returns toward baseline afterwards. This finding is valuable for surgery optimization and understanding of brain metabolism during ischemia.

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