Glymphatic System Imaging: From Neurofluid Transport to Neurodegeneration
Digital Poster
Neuro A
Thursday, 14 May 2026
This digital poster session focuses on glymphatic system structure, function, and dysfunction, highlighting its role in neurofluid transport, perivascular spaces, and brain waste clearance across the lifespan and disease states. The posters showcase advanced MRI and quantitative imaging approaches to link glymphatic alterations with cognition, neurodegeneration, vascular disease, sleep disorders, cancer therapy–related neurotoxicity, and metabolic and psychiatric conditions.
Skill Level: Basic,Intermediate,Advanced
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663-03-001.
Dynamic Contrast-Enhanced MR Fingerprinting for Whole-Brain Mapping of CSF Tracer Transport via Intraventricular Infusion
Impact: This study shows that DCE-MRF,
in combination with intraventricular tracer delivery, enables robust
quantification of whole-brain CSF tracer transport and distinct T₁/T₂ contrasts, establishing a
reproducible framework for glymphatic assessment and supporting future
dual-contrast imaging with Gd-DOTA and ¹⁷O-enriched water.
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663-03-002.
Glymphatic Failure Mediates Multisystem Neurodegeneration in ALS: Motor System Injury and Cognitive Dysfunction
Impact: This study provides
objective neuroimaging evidence linking glymphatic dysfunction to both motor
and cognitive impairments in ALS. It enables clinicians to utilize glymphatic metrics
as potential diagnostic and prognostic biomarkers, guiding earlier
interventions and motivating therapeutic strategies targeting waste clearance.
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663-03-003.
Glymphatic clearance partially mediates the relationship between amyloid and tau deposition in Alzheimer’s disease
Impact: Amyloid and
tau proteins are hallmarks of Alzheimer’s disease. This study aims to investigate
how glymphatic function might affect or mediate the relationship between the accumulation of amyloid and tau deposition,
potentially offering insights for intervention and therapeutic development.
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663-03-004.
Texture-Based Assessment of Neurofluid-Related White Matter Alterations in Obstructive Sleep Apnea
Impact: This study identifies texture analysis of T2-weighted MRI as a novel biomarker of neurofluid dynamics, bridging structural MRI and glymphatic imaging to reveal sleep-related alterations in brain water homeostasis in obstructive sleep apnea.
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663-03-005.
Glymphatic System Dysfunction Mediates Chemotherapy-Related Central Neurotoxicity in Nasopharyngeal Carcinoma Patients
Impact: Provides
MRI evidence of chemotherapy-induced glymphatic impairment, guiding targeted
interventions for brain protection in NPC patients.
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663-03-006.
Diffusion along the perivascular space may serve as a biomarker to differentiate glioma recurrence from pseudoprogression
Impact: This preliminary study highlights DTI-ALPS as a potential imaging biomarker that complements DTI metrics for differentiation of glioma recurrence from pseudoprogression, which may provide a new perspective for the early assessment of treatment response in glioma patients.
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663-03-007.
MRS-visible macromolecules are elevated in Parkinson's disease and are associated with perivascular space counts
Impact: MRS-visible macromolecular (MM) signals are
elevated in patients with Parkinson's disease, and are associated with
neurofluid clearance markers, suggesting that the MM levels are sensitive to
neurodegenerative changes and may represent a promising noninvasive marker for
brain clearance.
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663-03-008.
Non‑Invasive Assessment of Glymphatic Dysfunction in Middle Cerebral Artery Stenosis based on DTI-ALPS and ro-ALPS
Impact: This
study revealed significant differences in DTI-ALPS and ro-ALPS indexes between
MCA-S patients and healthy controls, providing novel neuroimaging biomarkers
for glymphatic dysfunction in MCA-S. This may help facilitate
early risk assessment and guide intervention strategies targeting glymphatic
clearance pathways.
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663-03-009.
Reliability of T1-weighted Intrathecal Contrast-Enhanced Images and Repeatability of T1 mapping in Brain Tissue and CSF
Impact: Specialized T1 mapping methods for brain tissue and CSF are more accurate for estimating contrast agent concentrations in the brain than the conventional approach. However, T1-weighted imaging is faster and provides a good estimate in the cerebral cortex.
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663-03-010.
Quantifying glymphatic-relevant fluid and detecting its mobility with extended-echo-range multi-echo GRE (QUTE) at 7T
Impact: The combination of QUTE‑based pCSF water content mapping and
Hankel/PCA‑based mobility markers offers a compact, modeling‑light framework to
probe glymphatic‑relevant fluid.
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663-03-011.
Quantitative MRI Evaluation of Glymphatic–Lymphatic Clearance by Low-intensity Focused Ultrasound in Non-human Primate
Impact: This study provides the first MRI evidence that low-intensity ultrasound can transiently enhance glymphatic and meningeal lymphatic transport in non-human primates, supporting the feasibility of non-invasive modulation and quantitative imaging of integrated brain clearance systems.
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663-03-012.
DTI-ALPS Quantification of Glymphatic Impairment Across Sleep Disorder phenotypes and Its Correlation with Symptom Severity
Impact: DTI-ALPS provides a non-invasive imaging biomarker of glymphatic function, quantifying sleep-dependent perivascular diffusion. This first comparative DTI-ALPS study across sleep phenotypes identifies distinct glymphatic signatures that may predict disease severity and monitor therapeutic modulation of brain waste clearance.
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