Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Quantitative Neuroimaging of Neurodegeneration, Metabolism, and Brain Microstructure

Quantitative Neuroimaging of Neurodegeneration, Metabolism, and Brain Microstructure

Digital Poster

Neuro A

Tuesday, 12 May 2026

Digital Posters Row I

08:20 - 09:15

Session Number: 468-01

No CME/CE Credit

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This digital poster session showcases advanced MRI biomarkers and quantitative imaging approaches across neurodegeneration, neurovascular disease, and systemic disorders affecting the brain. The abstracts highlight methodological innovation—from diffusion and elastography to perfusion, sodium MRI, QSM, and multimodal integration—with clear implications for disease characterization, progression, and treatment response.

Skill Level: Intermediate

		468-01-001. Microstructure Matters: DRTT Tract Quality as a Biomarker of VIM-DBS Response in Essential Tremor Sohae Chung, Ha Neul Song, Mert Sisman, Brian Kopell, Alon Mogilner, Yvonne Lui, Yi Wang, Ki Sueng Choi New York University Grossman School of Medicine, New York, United States of America Impact: Presurgical diffusion and MVF markers in the DRTT show strong relations with VIM-DBS tremor improvement, independent of disease duration. Embedding these microstructural/myelin relations into planning can personalize targeting, standardize outcomes, and enable decision support for tremor surgery.
		468-01-002. Assessing Brain Mechanical Anisotropy in Amyotrophic Lateral Sclerosis with MR elastography Shengyuan Ma, Peijun Zhao, Peng Hu, Yining Wang, Fuhua Yan, Guang-Zhong Yang, Torben Breithaupt, Michael Scheel, Ingolf Sack, Yuan Feng Shanghai Jiao Tong University, Shanghai, China Impact: TWE-NITI anisotropic MRE reveals ALS-related reductions in brain stiffness and mechanical anisotropy, notably in the inferior corpus callosum. All aspects of mechanical anisotropy decline in ALS, suggesting anisotropic MRE could serve as a sensitive longitudinal clinical microstructural biomarker.
		468-01-003. Non-invasive microstructural characterization of Iron Overload in Aceruloplasminemia patients Alexander Stürz, Marlene Panzer, Elke Gizewski, Heinz Zoller, Christoph Birkl Medical University of Innsbruck, Innsbruck, Austria Impact: This study shows that not only the amount of iron but also its microstructural distribution determine relaxation in tissue. Relaxometry combined with theoretical modelling provides deeper microstructural insight into neurodegenerative iron pathology in Aceruloplasminemia (ACP).
		468-01-004. Quantitative MRI assessment of cerebellar neurodegeneration and metabolic alterations in Lafora disease Lorenzo Motta, Greta Venturi, Francesca Punzetti, Lorenzo Muccioli, Raffaele Lodi, Francesca Bisulli, Caterina Tonon IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy Impact: This study reveals undetected cerebellar neurodegenerative alterations in Lafora disease through advanced quantitative MRI, highlighting iron accumulation and neuronal loss, and offering new insights into the disease’s pathophysiology beyond conventional imaging approaches.
		468-01-005. Imaging–Transcriptomic Decoding of Cortical Reorganization in SCA3 Using MIND Networks Xingang Wang, Yi-Cheng Hsu, Chen Liu Army Medical University (Third Military Medical University), Chongqing, China Impact: Cortical reorganization in SCA3 aligns with spatial gene-expression gradients. Using MIND networks from MRI plus AHBA-based imaging transcriptomics, we identify metabolic/ECM/vascular pathways and glial–endothelial signatures linked to regional morphometric disruption, nominating biologically grounded imaging markers for future trials.
		468-01-006. Simultaneous Dynamic Sodium MRI-EEG with Dual-VENC Quantification of CSF Flow Velocity During Human Sleep Ying-Chia Lin, Kennedy Watson, Sara Hejazi, Kamri Clarke, Malika Kumbella, Justin Quimbo, Simon Henin, Anli Liu, Arjun Masurkar, Yulin Ge, Yvonne Lui, Yongxian Qian Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, United States of America Impact: Findings highlight disrupted CSF pulsation in Alzheimer’s disease and demonstrate that dynamic ²³Na MRI–EEG can probe sleep-related brain-clearance pathways, opening new avenues to study vascular health, CSF Clearence, glymphatic impairment, and potential interventions improving waste removal in neurodegeneration.
		468-01-007. White Matter Microstructural Alterations in Multi-System Atrophy Revealed by Multi-Model Diffusion TBSS Chuanying Shi, Peng Wu, Lu Han Jinan Central Hospital, Jinan, China Impact: This systematic assessment of white matter microstructural changes in MSA patients not only enhances our understanding of the disease pathology but also offers valuable imaging-based evidence for patient stratification and treatment evaluation.
		468-01-008. Trial-Ready Power Estimates for Longitudinal Resting-state fMRI Biomarkers in ALS Pedram Parnianpour, Sanjay Kalra, Erik Pioro University of British Columbia, Vancouver, Canada Impact: Trial-ready power estimates demonstrate that rs-fMRI functional connectivity can detect longitudinal ALS-related change with as few as 11 participants per group in a one-year trial, while shorter trials substantially inflate sample size, informing efficient design of emerging molecular therapy studies.
		468-01-009. MRI-Derived OEF and BBB Permeability Correlate with Neurological Severity in Wilson’s Disease Chuan Liu, Lingyun Liu, Miao Lin, Yunzhu Wu, Zixuan Lin, Shuyue Wang, Yi Dong Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China Impact: We demonstrate for the first time in Wilson’s disease that vascular insufficiency and blood–brain barrier disruption, detected by multimodal quantitative MRI, correlate with neurological severity, establishing novel biomarkers for noninvasive monitoring disease progression, and for evaluating chelation or vascular-targeted therapies.
		468-01-010. Sub-voxel QSM Reveals Differential Iron and Myelin Pathology in Pre-diabetes and T2DM Cognitive Dysfunction Jiali Liang, Muliang Jiang, Bin Tian, Xi Deng, Haifeng Zheng, Hui Zhang, Xingye Yang, Rong Wang The First Affiliated Hospital of Guangxi Medical University,, Nanning, China Impact: This study provides novel insights into the changes of iron and myelin pathology in diabetes-related cognitive impairment, highlighting unique early myelin alterations in the pre-diabetic stage.
		468-01-011. Elevated Oxygen Extraction in Type 2 Diabetes: Early Cerebral Metabolic Changes in Cognition-Related Brain Regions Dhruv Bhagat, Sri Sai Akkineni, Lea Bergeot, Fahad Salman, Ferdinand Schweser, Junghun Cho, Rafeeque Bhadelia, Katherine Tucker, Salil Soman Medical College of Georgia, Augusta, United States of America Impact: This study identifies elevated brain oxygen extraction fraction (OEF) in Type 2 Diabetes Mellitus as an early marker of cerebral metabolic dysfunction, enabling earlier detection of diabetes-related cognitive risk and guiding clinicians toward targeted interventions before structural brain damage occurs
		468-01-012. Normative references for amygdala subregions across the lifespan and heterogeneous alterations in neurological diseases. Chao Zhang, Zhizheng Zhuo, Renlong Zhang, Shan Lv, Yifei Zhang, Yaou Liu Beijing Tiantan Hospital, Capital Medical University, Beijing, China Impact: Our study established the first large-sample normative references for the amygdala and its subregion volumes, and applied it to a variety of neurological diseases, which can fill the gap in standardized references for fine structural research and facilitate clinical translations.
		468-01-013. A WEPCAST-based Investigation: Blood-Brain Barrier Permeability and Cognitive Impairment in Type 1 Narcolepsy Yanjie Zhou, Chen Zhang, Zixuan Lin, Bing Yu Shengjing Hospital of China Medical University, Shenyang, China Impact: Neuroinflammation may mediate a significant increase in blood-brain barrier (BBB) permeability in Type 1 Narcolepsy (NT1), potentially representing a key mechanism underlying cognitive impairment in these patients.
		468-01-014. Early and dynamic changes in MRI-based morphometry of the cervical spinal cord in spinocerebellar ataxia type 1 Colette Reniers, Teije Prooije, Kirsten Kapteijns, Jack van Asten, Caterina Mariotti, Lidia Sarro, Anna Nigri, Marina Grisoli, Giulia Coarelli, Alexandra Durr, Tom Scheenen, Bart van de Warrenburg Radboud University Medical Center, Nijmegen, Netherlands Impact: Spinal cord imaging, especially at C2, emerges as an early and dynamic biomarker for SCA1. This shows its potential use for patient stratification, monitoring of progression, and potentially as an outcome measure in preventive trials.
		468-01-015. Frontal glutathione quantified with MRS: Relationship to perioperative neurocognitive changes in elderly patients Bing Yu, Chen Zhang, Hongbin Sun Shengjing Hospital of China Medical University, Shenyang, China Impact: The glutathione （GSH） levels of the medial prefrontal cortex (mPFC) in elderly patients undergoing total knee arthroplasty under intrathecal anesthesia may be related to perioperative parameters of executive functional changes.
		468-01-016. Higher fasting brain glucose is associated with lower gray matter volume in healthy adults Helena van Nieuwenhuizen, Botond Antal, Antoine Hone-Blanchet, Andrew Lithen, Liam McMahon, Bruce Jenkins, Eva-Maria Ratai, Lilianne Mujica-Parodi Stony Brook University, Stony Brook, United States of America Impact: Brain glucose measured by ¹H MRS identifies metabolic dysfunction before symptoms appear, enabling early intervention. These findings redirect focus from peripheral glucose management to brain-specific therapies targeting neural insulin sensitivity and alternative fuel utilization, guiding neuroprotective strategies for age-related neurodegeneration.