Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

Advances in Contrast Mechanisms

Power Pitch

Contrast Mechanisms

Tuesday, 12 May 2026

Power Pitch Theatre 1

13:40 - 15:16

Moderators: Grace McIlvain & Jingjia Chen

Session Number: 451-02

No CME/CE Credit

Similar Sessions

This session covers the latest advances in contrast mechanisms from chemical exchange saturation transfer (CEST) to quantitative susceptibility mapping (QSM).

Skill Level: Advanced

13:40		451-02-001. Mapping Molecular Brain Connectivity Using Glutamate-Weighted CEST MRI: Effects of Nicotine Joel Jarusek, Mariano Uberti, Adarsha Bhattarai, Chathumi Samaraweera, Dongming Peng, Aditya Bade, Yutong Liu University of Nebraska Omaha, Omaha, United States of America Impact: This study introduces a new imaging approach for mapping brain molecular networks using glutamate-specific CEST MRI. This approach provides neural connectivity information that cannot be obtained using fMRI, enabling new investigations into how morbidities alter brain chemistry and network function.
13:42		451-02-002. Visually stimulated functional Deuterium Metabolic Imaging (DMI following [2H2] and [2H7] glucose ingestion Max Espley, Daniel Cocking, Robin Damion, Dorothee Auer, Richard Bowtell NIHR Nottingham Biomedical Research Centre, Queen’s Medical Centre, Nottingham, United Kingdom Impact: This study investigates whether the use of glucose-d₇ as a non-invasive tracer enhances the sensitivity of functional Deuterium Metabolic Imaging (DMI) for detecting metabolite dynamics compared with glucose-d₂, aiming to provide insights into the metabolic underpinnings of neuronal activation.
13:44		451-02-003. Tissue sodium concentration and sodium T1 mapping of the monkey brain at 11.7 T using a Variable Flip Angle method Mariam EL BALQ, Alfredo Lopez Kolkovsky, maxime roustan, Thomas Lilin, Marion Gay, Armin NAGEL, Franck Mauconduit, Fawzi Boumezbeur CEA NeuroSpin, Paris-Saclay University, CNRS, Gif-Sur-Yvette, France Impact: Demonstrate the potential of high-resolution ²³Na MRI at 11.7 T here for preclinical research in NHP, with the perspective to accelerate acquisition through compressed sensing strategies.
13:46		451-02-004. Supplementing MR Arthrography with CT-like Isotropic 3D Radial UTE for comprehensive joint examination Badr Sellami, Hubert Raeymaekers, Stefan Sommer, Thomas Janssens, Vincent Denolin, PETER VAN SCHUERBEEK, Maarten Naeyaert, Mimoun Kichouh, Manon Roose Universitair Ziekenhuis Brussel, Brussels, Belgium Impact: This work initiates a validation study of MR arthrography + 3D UTE in ankles and shoulders, comparing its comprehensiveness to that of MR arthrography + CT. Also, 3D UTE will be further evaluated in SIJs to complete routine MRI.
13:48		451-02-005. High-resolution 7T QSM reveals laminar and subcortical susceptibility alterations in paediatric focal epilepsy Chiara Casella, Katy Vecchiato, Ayse Sila Dokumaci, Philippa Bridgen, Pierluigi Di Cio, Shaihan Malik, Jo Hajnal, Sharon Giles, Jan Sedlaik, Karin Shmueli, David Carmichael, Jonathan O'Muircheartaigh King's College London, London, United Kingdom Impact: 7T QSM enhances understanding of epileptogenic tissue organisation in paediatric focal epilepsy and may facilitate localisation of epileptogenic foci for surgical planning as well as serve as a quantitative biomarker for monitoring progression or treatment response.
13:50		451-02-006. Guanidinium CEST from Double-Step Multi-Pool Lorentzian Fitting Correlates with Creatine Measured by MRS in the Human Brain Ziyan Wang, Huabin Zhang, Jiawen Wang, Jianpan Huang The University of Hong Kong, Hong Kong, China Impact: At clinical 3T, DMPLF allows for reliable quantification of the GuanCEST signal, which shows a strong correlation with total creatine concentration measured by MRS in the human brain, providing a robust method for CEST analysis in clinical MRI settings.
13:52		451-02-007. Magnetization Transfer Physics Validation at an Ultra-Low Field Strength David Korenchan, Neha Koonjoo, Sheng Shen, Chetan Dhakan, Scott Swanson, Matthew Rosen, Christian Farrar Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America Impact: We confirm that high-field quantitative MT models translate readily down to 6.5 mT, establishing the interpretability of low-field MT imaging and confirming its utility for low-cost, point-of-care screening and diagnosis.
13:54		451-02-008. Characterizing Metabolic and Compositional Heterogeneity of Calf Muscle using CEST MRI at 3 T Huabin Zhang, Kangli Pi, Ziyan Wang, Fan Huang, Juan Wei, Patrick Liebig, Yi Zhang, Varut Vardhanabhuti, Jianpan Huang The University of Hong Kong, Hong Kong, Hong Kong Impact: This study demonstrates CEST MRI as a sensitive tool for non-invasively characterizing muscle-specific metabolic and compositional alterations. These changes are closely associated with adiposity and body composition, providing molecular-level insights into muscle physiology and health.
13:56		451-02-009. Measuring cardiac tissue electrical conductivity with phase-based MREPT Jun Cao, Brendan Moran, Iain Ball, Caroline Rae Neuroscience Research Australia, Sydney, Australia Impact: Reliable in vivo conductivity mapping provides a potential biomarker for studying myocardial ischemia and fibrosis.
13:58		451-02-010. Label-free drug delivery monitoring and therapeutic response prediction in osteosarcoma Sijie Yuan, Qin Yu, Qingqing Wen, Yue Yuan University of Science and Technology of China(USTC), Hefei, China Impact: This integrated platform synergizes label-free drug delivery monitoring with enhanced imaging sensitivity and effective osteosarcoma therapy. It offers a promising theranostic approach for imaging-guided treatment and real-time prediction of therapeutic response on standard 3.0 T clinical scanners.
14:00		451-02-011. Total magnetic moment on QSM enables vendor- and parameter-independent quantification of cerebral microbleeds Chao Zhang, Mert Sisman, Alexey Dimov, Carly Skudin, Gloria Chiang, Yi Wang Weill Cornell Medicine, New York, United States of America Impact: Quantitative susceptibility mapping enables total magnetic moment measurement of cerebral microbleeds, providing a universal, parameter-independent biomarker reproducible across echo times, voxel sizes, field strengths, and vendors, thus standardizing ARIA-H assessment during anti-amyloid therapy.
14:02		451-02-012. In Vivo Anisotropic Myocardial Stiffness Mapping Using ECG-Gated Electromagnetic Multifrequency MRE with TWE-NITI Inversion Chengyuan Yu, Shengyuan Ma, Runke Wang, Fuhua Yan, Guang-Zhong Yang, Peng Hu, Yining Wang, Yuan Feng School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China Impact: Anisotropic inversion of myocardial MRE data allows directionally resolved stiffness characterization with improved biophysical fidelity. This advancement enhances sensitivity to early myocardial remodeling and may facilitate early detection and risk stratification in cardiovascular disease.
14:04		451-02-013. Foundations of susceptibility source separation for studying brain aging: the age dependence of the relaxometric constant Niklas Kuegler, Taechang Kim, Shir Filo, Agnieszka Burzynska, Kerrin Pine, Mikhail Zubkov, Puneet Talwar, Gilles Vandewalle, Felix Büttner, Valerij Kiselev, Jongho Lee, Nikolaus Weiskopf, Evgeniya Kirilina Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany Impact: Our results provide both a theoretical foundation and an empirical basis for applying susceptibility source separation in studies of brain aging, paving the way for probing microstructural changes that underlie brain longevity and age-related decline.
14:06		451-02-014. Multi-scale molecular architecture of cortical iron in Parkinson’s disease Jianmei Qin, Lydia Chougar, Alain Dagher, Xiaojun Guan, Minming Zhang Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China Impact: QSM detects early cortical iron accumulation before atrophy. By linking these regional changes to functional networks, cytoarchitectonic tissue, and laminar/cell-class transcriptomics, this study reveals mechanisms of cortical vulnerability and supports QSM as a biologically grounded imaging biomarker for Parkinson’s disease.
14:08		451-02-015. Acute Decreased Perfusion in the Brain Causes Compensatory Decrease in Stiffness Mary Kramer, Gabriella Dunay, Fiona Horvat, Nathan Romberger, Christopher Martens, Curtis Johnson University of Delaware, Newark, United States of America Impact: Cerebral blood flow and brain stiffness were found to be directly coupled, particularly in the most vascularized regions of the brain. Studies examining changing blood flow and stiffness in the brain should consider this relationship in their interpretation of results.
14:10		451-02-016. Evaluating reproducibility of super-selective arterial spin labeling in healthy volunteers and cerebrovascular diseases Gabriel Hoffmann, Matthias Toth, Miriam Reichert, Michael Helle, Kilian Weiss, Jan Kirschke, Christine Preibisch, Stephan Kaczmarz, Nico Sollmann Technical University of Munich, Munich, Germany Impact: Our results indicate that ss-pCASL enables reliable and reproducible vascular territory mapping. Particularly in cerebrovascular-diseased patients, the main pathologic features such as shift or elevated CBF could be reproduced, indicating high potential for facilitating non-invasive assessment of collateral blood supply.
14:12		451-02-017. Advancing contrast enhanced MRI – The potential of the new contrast agent Gadoquatrane Hubertus Pietsch, Stephan Gruendemann, Jessica Lohrke, Janina Boyken, Gregor Jost Bayer AG, Berlin, Germany Impact: Gadoquatrane, a novel tetrameric high-relaxivity gadolinium-based contrast agent (GBCA) shows substantially lower skeletal gadolinium concentration in rats than comparators at clinical-equivalent doses, supporting that this new high relaxivity GBCA maximizes kinetic inertness and minimizes tissue Gd presence.
14:14		451-02-018. Quantitative MRI of Pulmonary and Abdominal Vascular Flow and Cardiac Function in a single Ferumoxytol-Enhanced 4D-Flow Scan Bryden Fong, Jing Liu, Yoo Jin Lee, Alex Gill, Evan Kao, Miles Conrad, Michael Ohliger, Daniel Langston, Jonas Schollenberger, Joseph Bayne, Steven Hetts, David Saloner University of California San Francisco — Radiology and biomedical imaging, San Francisco, United States of America Impact: The ability to acquire high quality images at multiple stations with consistent luminal signal over an extended scan time could greatly facilitate the evaluation of patients with multi-organ disease.