Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

Neuroinflammation: Fluids and Flow

Digital Poster

Neuro A

Wednesday, 13 May 2026

Digital Posters Row F

08:20 - 09:15

Session Number: 565-01

No CME/CE Credit

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This digital poster session brings together cutting-edge research on the brain’s fluid and barrier systems in neuroinflammation. Presentations highlight advanced neuroimaging techniques and their application to multiple sclerosis, NMOSD, and other neuroinflammatory conditions. Collectively, the posters explore how alterations in neurofluid dynamics and microenvironment contribute to inflammation, tissue injury, and clinical outcomes, offering emerging biomarkers and potential translational insights.

		565-01-001. Dynamic PET unmasks a reduced Blood-CSF Barrier permeability at the choroid plexus level in multiple sclerosis Amelle Nasri, Vito AG RICIGLIANO, Michelle Carranza Mellana, Mariem Hamzaoui, MILENA SALES PITOMBEIRA, Natalia Shor, Juliette Dufour, Paolo Mellino, Théodore Soulier, Andrea Lazzarotto, Mattia Veronese, Vincent Brulon, Michel Bottlaender, Jean-Leon Thomas, Daniele de Paula Faria, Benedetta Bodini, Bruno Stankoff Paris Brain Institute, Paris, France Impact: To characterize functional choroid plexus alterations in multiple sclerosis (MS), we developed a novel PET metric that revealed a decreased blood-to-cerebrospinal fluid barrier permeability in choroid plexuses in MS but not Alzheimer's disease, a parameter strongly linked to disease severity.
		565-01-002. High-resolution 3D-T2WI with AIR Recon DL for perivascular space visualization in multiple sclerosis Amo Ozawa, Tomohiro Shintaku, Sera Kasai, Yuka Ishimoto, Taiki Koshiishi, Mizuki Imura, Kana Saito, Kazuhiko Oyu, Atsushi Nozaki, Tetsuya Wakayama, Shingo Kakeda Hirosaki University Graduate School of Medicine, Hirosaki, Japan Impact: High-resolution 3D_ARDL enables consistent detection of small subcortical PVS in MS. This technique may facilitate earlier detection of disease activity and enhance understanding of MS pathophysiology.
		565-01-003. Filter exchange imaging (FEXI) reveals subtle normal-appearing tissue blood-brain barrier dysfunction in MS Elizabeth Powell, Jack Allen, Baris Kanber, Ferran Prados Carrasco, David Higgins, Valeria Pozzilli, Marios Yiannakas, Anestis Passalis, Fatima Pansari, Floriana De Angelis, Geoff Parker University College London, London, United Kingdom Impact: Measurement of blood brain barrier (BBB) water exchange using filter exchange imaging (BBB-FEXI) reveals widespread changes in BBB function in normal-appearing tissue in multiple sclerosis (MS) not seen with gadolinium leakage. These measurements increase our understanding of MS disease mechanisms.
		565-01-004. Association of MRI Indices of the Perivascular Space Network with disease pathology and disability in Multiple Sclerosis ZHANG HAO, Cui Lingling, Cao Jibin, ruisi gong, Jinlin Jiao, Li Mengyao, Yueluan Jiang The First Hospital of China Medical University, Shenyang, China Impact: This study validates glymphatic dysfunction as a key MS mechanism, providing non-invasive MRI biomarkers for disability and neurodegeneration to guide research, personalized care, and targeted therapies.
		565-01-005. Glymphatic Dysfunction in Multiple Sclerosis and its Association with Brain Structural Damage and Cognitive Impairment Zhuo Wang, Kai AI, Peng Wu, Jing Zhang The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China Impact: This study provides the evidence that choroid plexus volume enlargement is linked to impaired glymphatic function in RRMS. We identify glymphatic dysfunction as a key mechanism underlying cognitive decline.
		565-01-006. Choroid Plexus Cysts on 7T MRI Differentiate NMOSD from MS Zhiming Zhen, Siyao Xu, Can Xu, Yunyun Duan, Ying-Hua Chu, Yi-Cheng Hsu, Peiyu Huang, Yaou Liu, Li Gui, Chen Liu Army Medical University (Third Military Medical University), Chongqing, China Impact: In young patients, 7T MRI revealed more frequent and distinct choroid plexus cysts in AQP4+ NMOSD than in RRMS. CPCs were quantifiable and sometimes present without brain lesions, suggesting a practical imaging marker to aid differential diagnosis.
		565-01-007. Elevated Choroid Plexus Blood Flow in NMOSD Linked to Cognitive and Emotional Deficits Nan Meng, Xi Li, Bing Liu, Xiuzheng Yue, Fuxin Ren, Fei Gao Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, China Impact: Identifies elevated choroid plexus blood flow (ChP-CBF) in NMOSD as a novel MRI biomarker for neuroinflammation-related cognitive-emotional impairments, aiding diagnosis and guiding therapies like anti-complement agents.
		565-01-008. Choroid plexus alterations link metabolic syndrome severity to cognitive domains: neuroimaging evidence from two cohort Xinxin Huo, TAO Chen, Zhenyu Cheng, Boyao Chen, Fushuai Zhang, Yiwen Chen, Pengcheng Liang, Nan Zhang, Yenan Che, Jiaxiang xin, Changhu Liang, Lingfei Guo, Meng Li Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, China Impact: CP enlargement may indicate central metabolic and inflammatory alterations driven by MetS, linking peripheral metabolic dysfunction to cognitive decline, and serving as a potential neuroimaging biomarker of metabolic brain injury.
		565-01-009. ‌Choroid Plexus Changes and Cognitive alterations in Migraine Patients Yiwen Zhang, Fei Gao, Xinwu Ma, Fuxin Ren, Xiuzheng Yue Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, China Impact: This study may elucidate the pivotal role of the choroid plexus in migraine-related cognitive impairment, providing novel imaging biomarkers and theoretical foundations for early identification and intervention of migraine.
		565-01-010. The Choroid Plexus in Brain Waste Clearance: Key Predictors of Volume and Impact on Aβ Deposition Under Anti-Amyloid Therapy Xinyi Huang, Qian Xiao, Li Zhao, Xingfeng Shao, Weijia Liu, Ye Yao, Yiming Wang, Yao Li, Zixuan Lin, Dengrong Jiang National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), Shanghai Jiao Tong University, Shanghai 200240, China Impact: We identified age, male sex, and APOE4 status as key predictors of increased choroid plexus volume. Larger choroid plexus volume correlated with slower Aβ deposition rates, highlighting its important role in brain waste clearance.
		565-01-011. Dysfunction of the Brain's Microenvironment in Cognitive Impairment of SLE: A Free Water and DTI-ALPS Study zhaoli zheng, Hu Liu, Xinguang Zhao, Yueluan Jiang The First Hospital of China Medical University, Shenyang, China Impact: Free water imaging and the DTI-ALPS index serve as sensitive biomarkers for detecting brain microenvironment alterations in SLE patients with cognitive impairment, enabling early risk identification and guiding targeted interventions to improve patient outcomes.
		565-01-012. Serostatus-Independent Free-Water Fraction in Cervical Spinal WM in NMOSD: Equivalence Analysis with diffusion Standard Model Masaaki Hori, Akifumi Hagiwara, Takafumi Kitagawa, Kouhei Kamiya, Issei Fukunaga, Katsutoshi Murata, Julien Cohen-Adad, Shigeki Aoki, Koji Kamagata Toho University, Tokyo, Japan Impact: FWF is serostatus-equivalent (±0.02) and exhibits a stable segmental gradient, enabling serostatus-agnostic pooling, simpler acquisition, and level-normalized monitoring that strengthen multicenter harmonization and longitudinal care in NMOSD.
		565-01-013. Decoupling of gBOLD Signals from CSF Flow Reveals Glymphatic Dysfunction in Idiopathic Normal Pressure Hydrocephalus 思亭许 Huadong Hosptial, Fudan University, Shanghai, China Impact: This study identifies gBOLD-CSF coupling as a neurophysiological biomarker of impaired glymphatic clearance in iNPH and demonstrates its predictive value for cognitive improvement following shunt surgery, providing a mechanistically informed target for treatment selection and monitoring.