Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Hyperpolarization: Novel Applications

Hyperpolarization: Novel Applications

Digital Poster

Contrast Mechanisms

Tuesday, 12 May 2026

Digital Posters Row F

08:20 - 09:15

Session Number: 465-01

No CME/CE Credit

Similar Sessions

For researchers and clinicians interested in the latest advances of hyperpolarization

		465-01-001. Evidence of compartmentalized redox equilibria in hyperpolarized 13C MRI of the brain Dylan Dingwell, Biranavan Uthayakumar, Nicole Cappelletto, Albert Chen, Hany Soliman, Charles Cunningham University of Toronto, Toronto, Canada Impact: Modelling of human hyperpolarized 13C MRI reproduced in vivo evidence of lactate oxidation using a multi-compartment model, clarifying the importance of compartment-specific redox dynamics and facilitating further investigation of mitochondrial lactate consumption and intercellular monocarboxylate shuttling using 13C MRI.
		465-01-002. Probing intratumoral metabolic compartmentalisation in FHd-RCC using clinical HP 13C-MRI and MSI Ines Horvat-Menih, Ruth Casey, James Denholm, Gregory Hamm, Heather Hulme, John Gallon, Alixander Khan, Joshua Kaggie, Andrew Gill, Andrew Priest, Joao Duarte, Cissy Yong, Cara Brodie, James Whitworth, Simon Barry, Richard Goodwin, Shubha Anand, Marc Dodd, Katherine Honan, Sarah Welsh, Anne Warren, Tevita Aho, Grant Stewart, Thomas Mitchell, Mary McLean, Ferdia Gallagher University of Cambridge, Cambridge, United Kingdom Impact: HP ¹³C-MRI may be a promising technique to characterise FHd-RCC. This could guide biopsies to regions of highest metabolic dysregulation to obtain the tumour samples of greatest clinical significance, which in turn can guide treatment decisions and inform response.
		465-01-003. Accelerating hyperpolarized 13C urea brain perfusion imaging using L+S reconstruction with dual-tree wavelet regularization Minjie Zhu, Yaewon Kim, Dan Vigneron, Jeremy Gordon University Of California, San Francisco (UCSF), United States of America Impact: The proposed reconstruction method enables a threefold acceleration in ¹³C urea perfusion imaging without introducing significant artifacts, thereby enhancing temporal resolution and improving the quantification of cerebral blood flow.
		465-01-004. UV-induced hyperpolarization for in vivo 13C-MRI in awake mice: comparison with the trityl radical method Maiko Ono, Andrea Capozzi, Kosei Hirata, Chikara Yamauchi, Keita Saito, Mor Mishkovsky, Yuhei Takado National Institutes for Quantum Science and Technology, Chiba, Japan Impact: This study highlights the biological applicability of UV-induced hyperpolarized [1-¹³C]D-pyruvate. Using MRSI, we detected early hippocampal metabolic alterations in an Alzheimer’s disease mouse model, supporting its potential as a translational tool for probing metabolic pathology in neurodegenerative diseases.
		465-01-005. Comparative evaluation of hyperpolarized [13C]pyruvate and [13C]lactate for imaging neuronal and glioma metabolism Jun Chen, Jaideep Chaudhary, Zohreh Erfani, Sarah Al Nemri, Erik Plautz, Erin Seeley, Xiaodong Wen, Brenda Bartnik-Olson, Ian Corbin, Jae Hong Park University of Texas Southwestern Medical Center, Dallas, United States of America Impact: This work presents the relative strengths of hyperpolarized pyruvate and lactate as neurometabolic imaging agents, establishing guidelines for interpreting cerebral products of hyperpolarized lactate and pyruvate and for assessing neuronal and glioma metabolism in vivo.
		465-01-006. Pharmacokinetic Modeling with a Convolutional Neural Network of Hyperpolarized 13C-Pyruvate MRI Metabolism in the Human Heart Mario Quicana, Anna Bennett Haller, Dillon Yeh, Sule Sahin, Nikhil Deveshwar, Avantika Sinha, Peder Larson University of California at Berkeley, berkeley, United States of America Impact: This digital phantom-based framework enables training and validation of deep learning models for quantification of cardiac metabolism with hyperpolarized 13C-pyruvate MRI. These models can integrate spatial and kinetic information for more robust maps of metabolism.
		465-01-007. SABRE-Hyperpolarized [1-13C]ketoisocaproate-d2 Allows Profiling of Branched-Chain-Amino-Acid Transferase in vitro and in vivo Stefan Petersen, Philipp Groß, Paul Schmidt, Henri de Maissin, Robert Willing, Adriana Sacristán-Martín, Lisa Heß, Sebastian Lucas, Maxim Zaitsev, Dominik von Elverfeldt, Martin Grashei, Franz Schilling, Max von Delius, Thomas Reinheckel, Andreas Schmidt University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany Impact: This work establishes SLIC-SABRE-hyperpolarized [1-¹³C]ketoisocaproate-d₂ as a rapid, cost-effective approach to probe branched-chain-amino-acid metabolism, enabling metabolic phenotyping of breast cancer and expanding the repertoire of parahydrogen-based hyperpolarized ¹³C agents for biomedical MRI
		465-01-008. An integrated HP [¹³C,¹⁵N₂]Urea + [1-¹³C]Pyruvate MRI Approach for Measuring Human BBB Integrity and Cerebral Metabolism Yaewon Kim, Hsin-Yu Chen, Minjie Zhu, Duy Dang, James Slater, Charlie Wang, Jeremy Gordon, Chris Suszczynski, Sri Maddali, Adam Gaunt, Rui Chen, Javier Villanueva-Meyer, Duan Xu, Peder Larson, Robert Bok, Susan Chang, Dan Vigneron University Of California, San Francisco (UCSF), United States of America Impact: This study demonstrated the feasibility of combining hyperpolarized [¹³C,¹⁵N₂]urea and [1-¹³C]pyruvate MRI to probe cerebral perfusion and metabolism, enabling new opportunities for noninvasive assessment of blood–brain barrier integrity and neurovascular dysfunction in neurological diseases.
		465-01-009. Extraction of the vascular component of 13C-pyruvate signal: correlation with ASL Biranavan Uthayakumar, Dylan Dingwell, Nicole Cappelletto, Albert Chen, Nathan Ma, Chris Heyn, Hany Soliman, Charles Cunningham University of Toronto, Toronto, Canada Impact: Kinetic modelling of hyperpolarized [1-13C]-pyruvate MRI enabled regional CBF estimation, yielding more physiologically meaningful perfusion measures compared to unmodeled signals. However, weak correlations with arterial spin labelling CBF suggest that additional physiological factors influence the distribution of [1-13C]- pyruvate distribution.
		465-01-010. The 13C-metabolite profile of white matter hyperintensities measured with hyperpolarized 13C-pyruvate MRI Nicole Cappelletto, Hany Soliman, Biranavan Uthayakumar, Arjun Sahgal, Albert Chen, Ruby Endre, Nathan Ma, William Perks, Chris Heyn, Charles Cunningham University of Toronto, Toronto, Canada Impact: Hyperpolarized ¹³C-pyruvate MRI reveals decreased ¹³C-metabolism in white matter hyperintensities and may aid in understanding their underlying pathophysiology, etiology, and developmental phases. To our knowledge, this is the first report of hyperpolarized ¹³C MRI signals measured in white matter hyperintensities.
		465-01-011. Hyperpolarized ¹³C-pyruvate first-pass metabolism reflects the first-pass perfusion pattern observed with [¹⁵O]H₂O PET/CT Niels Jespersen, Esben Hansen, Steen Joergensen, Christoffer Laustsen, Henrik Wiggers, Lars Gormsen, Lotte Bonde Bertelsen, Rasmus Tougaard Aarhus University, Aarhus, Denmark Impact: The strong correlations between hyperpolarized MRSI metabolites and PET-derived myocardial blood flow supports the potential of hyperpolarized cardiac MRSI in ischemic heart disease. This opens new avenues for novel insights into cardiac substrate use, viability assessment, and metabolic remodeling.
		465-01-012. Exercise-Induced Modulation of Myocardial Substrate Utilization Measured with Hyperpolarized [1-¹³C] Pyruvate CMR Avantika Sinha, Anna Bennett Haller, Minjie Zhu, Adam Gaunt, Donghyun Hong, Irvane Kamga, Erin Argentieri, Michael Salerno, Moriel Vandsburger, Roselle Abraham, Peder Larson University Of California, San Francisco (UCSF), United States of America Impact: We demonstrate the feasibility of HP ¹³C-pyruvate MRI to capture acute metabolic changes in the left-ventricular myocardium using low to moderate lower-limb exercise in the scanner. Our results showed increased lactate and bicarbonate production after exercise in a fasted state.
		465-01-013. 1H PRESS Detection of Hepatic Lactate at 3T and Correlation with Hyperpolarized 13C MRI Wen Yen Chai, Ching-Yi Hsieh, Cheng-En Hsieh, Ying-Chieh Lai, Gigin Lin Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan Impact: This study demonstrates that long-TE $^1$H PRESS at 3 T can reliably detect hepatic lactate and correlates with hyperpolarized $^{13}$C MRI, highlighting its potential as a noninvasive biomarker for assessing metabolic alterations and therapeutic response in liver cancer.
		465-01-014. Stimulus-Locked Metabolic Response Functions Across ¹H-fMRS, ²H Labeling, and Hyperpolarized ¹³C. Camille Begon, Fatemeh Anvari Vind, Sotirios Katsikis, Rolf Gruetter, Mor Mishkovsky, Nathalie Just EPFL, Lausanne, Switzerland Impact: This work provides a predictive framework for matching stimulation paradigms to MRS modalities, enhancing the sensitivity and interpretability of glutamate imaging. It enables more precise probing of neuroenergetics across timescales, advancing functional MRS as a tool for brain metabolism research.
		465-01-015. ¹³C carbonyl polarization via intermolecular water NOE in multiple biomolecules Elton Montrazi, Korin Butbul, Lucio Frydman Weizmann Institute, Rehovot, Israel Impact: We found that ¹³C carbonyls in multiple biomolecules –bicarbonate, acetate, pyruvate, alanine lactate– can be polarized by intermolecular NOE from water. This can be combined with hyperpolarized water, enriching the ¹³C sensitivity for spectroscopy or imaging purposes.
		465-01-016. Understanding metabolic differences in amyloid-beta and tau pathology by in vivo hyperpolarized mri Julia Zickus, José Enriquez, Khloe Kelley, Bill Sun, Aldo Morales, Jorge DeLaCerda, Xudong Qiu, Muxin Wang, David Piwnica-Worms, Seth Gammon, Jeffrey Wefel, William Ray, Pratip Bhattacharya The University of Texas MD Anderson Cancer Center, Houston, United States of America Impact: Current approaches to study AD as a solely plaque-based pathology has been unsuccessful. Diagnostic tools are invasive and expose patients to radioactivity. HP-MRI can distinguish Ab and tauopathies that may delineate the mechanism of AD development and interrogate treatment efficacy.