Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Advances in Neuroimaging and Biomarkers for Brain Health and Disease

Advances in Neuroimaging and Biomarkers for Brain Health and Disease

Digital Poster

Neuro A

Tuesday, 12 May 2026

Digital Posters Row B

16:00 - 16:55

Session Number: 461-05

No CME/CE Credit

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This digital poster session showcases cutting-edge neuroimaging techniques and emerging biomarkers that advance understanding of brain health, ageing, and neurodegenerative disease, including applications in Alzheimer’s disease, diabetes, mild traumatic brain injury, and neuropsychiatric disorders. By integrating advanced MRI methods with molecular approaches such as spatial transcriptomics, the session highlights innovations that improve early detection, disease characterization, and monitoring of cognitive decline.

		461-05-001. Inferring local hemodynamics with PC-fMRA measures in arteries and veins: initial results estimating artery-vein transit time Zhangxuan Hu, Grant Hartung, Sébastien Proulx, Divya Varadarajan, Bruce Rosen, Jonathan Polimeni Stanford University, Stanford, United States of America Impact: We present an initial application of phase-contrast fMRA measures from individual arteries and veins to inferring local tissue hemodynamics. Such “vessel-specific fMRI” provides direct measures of vascular responses representing inputs to and outputs of biophysical models of fMRI dynamics.
		461-05-002. SupremeT1 FGATIR-MPRAGE MRI at 3T Chan Hong Moon, Jinsuh Kim University of Pittsburgh, Pittsburgh, United States of America Impact: SupremeT1 MRI is helpful in targeting small deep brain nuclei during DBS requiring also clear entire brain anatomy. Accurate localization of various nuclei would be advantageous for applications such as seeding for connectivity.
		461-05-003. EEG with DP-ASL MRI reveals sleep-related changes in CBF and BBB water exchange after partial sleep deprivation in adults Ziyang Huang, Soonhyun Yook, Xingfeng Shao, Yaqiong Chai, Chenyang Zhao, Zixuan Liu, Hosung Kim, Danny Wang Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, United States of America Impact: The combination of the two modalities—EEG estimating wake and sleep depth and DP-ASL providing water dynamics of BBB at superior spatial resolution—clarifies the interactive relationship between sleep and BBB water exchange underlying glymphatic function.
		461-05-004. Ultrafast MRI Reveals Multiband Cerebrospinal Fluid Oscillations in the Mouse Lateral Ventricles Sushil Bohara, Shella Keilholz Emory/Georgia Tech, Atlanta, United States of America Impact: Using a 9.4T MRI, we captured cerebrospinal fluid (CSF) inflow into the mouse lateral ventricles for the first time. This enables assessment of cardiac, respiratory, and neural oscillations and provides a framework for evaluating neurovascular coupling and brain health.
		461-05-005. Feasibility of In Vivo 3D Whole-Brain Transient Motion Imaging Xiang Shan, Yi Sui, Yuan Le, Emi Hojo, Daiki Ito, David Soma, Daniel Christoffer, Armando Manduca, Richard Ehman, John III Huston, Ziying Yin Mayo Clinic, Rochester, United States of America Impact: This study demonstrates a robust in vivo method for mapping whole-brain mechanical transient responses within acceptable scan times. This approach provides a foundation for future studies exploring mechanical susceptibility and potential regional vulnerability in populations exposed to repetitive head impacts.
		461-05-006. Simultaneous angiography, venography, and structural imaging using ASL with a dual-echo tiny golden angle radial sequence Ziyi Huang, Tianrui Zhao, Sang Hun Chung, Lirong Yan Northwestern University, Chicago, United States of America Impact: This work presents an efficient, high-resolution, “all-in-one” cerebrovascular sequence enabling simultaneous angiography, venography, and structural imaging within a single short acquisition. It offers a time-efficient imaging tool for comprehensive cerebrovascular assessment and may improve diagnosis of stroke and neurovascular disorders.
		461-05-007. Feasibility of Simultaneous CSF-STREAM–EEG at 7T: Toward Mapping of Sleep-Dependent CSF-Dynamics Balázs Örzsik, Emiel Roefs, Nina Fultz, Madda Debiasi, Rolf Fronczek, Lydiane Hirschler, Matthias van Osch Leiden University Medical Center, Leiden, Netherlands Impact: This work enables safe, high-field EEG–MRI integration beyond fMRI, allowing investigation of sleep-dependent cerebrospinal fluid dynamics in humans. It establishes a foundation for future ultra high-field EEG–MRI studies of brain clearance and sleep-related physiology.
		461-05-008. Mapping pulsatility along the vascular tree using time-encoded arterial spin labeling MRI Maaike van Tol, Natalia Petridou, Matthias van Osch, Lena Vaclavu Leiden University Medical Center, Leiden, Netherlands Impact: Non-invasive quantification of cerebral pulsatility in the gray matter across the arterial tree is accomplished through retrospective binning of multi-delay arterial spin labeling images. This approach may be used to investigate spatial pulsatility patterns in aging or vascular dementias.
		461-05-009. Quantifying Spinal cerebrospinal fluid and cerebral blood flows interactions in rat using Phase Contrast MRI Sidy Fall, Christian Bassinot, Liu Pan, Catherine Vilpoux Buquet, Olivier Baledent University Centre for Health Research (CURS, PIRMPA), University of Picardy Jules Verne, Amiens, France Impact: Quantitative PC-MRI of cerebrospinal fluid (CSF) in rats was relatively rare and was limited to the aqueduct. We measured CSF-flow in the spinal subarachnoid space. This optimized protocol could be useful for studying the pathophysiology of diseases involving CSF disturbances.
		461-05-010. Feasibility of Ultra-High field MRI for assessing small artery structure and haemodynamics in children Ioana Pinzaru, Anthony Price, Alan Wright, Philippa Bridgen, Pierluigi Di Cio, Inka Granlund, Lucy Billimoria, Sharon Giles, Ming Lim, Maria Zuluaga, Daberachi Amaechi, Andrew MacKinnon, Chinedu Maduakor, Henry Mandeville, Ugochi Akerele, Shaihan Malik, Jonathan O'Muircheartaigh, David Carmichael, Saras Sabanathan, Samah Babiker, Philip Benjamin, Jon Cleary King's College Hospital NHS Foundation Trust London, London, United Kingdom Impact: We performed time-of-flight lenticulostriate artery angiography and phase contrast flow measurements in four younger children at 7-Tesla. This may open new opportunities to probe microvascular abnormalities in paediatric stroke and vasculopathies affecting these tiny vessels.
		461-05-011. Accelerated MCDW-pCASL Using Subspace Low-Rank Reconstruction for Quantification of BBB Water Exchange and Permeability Zixuan Liu, Xingfeng Shao, Chenyang Zhao, Ziyang Huang, Fanhua Guo, Danny Wang University of Southern California, Los Angeles, United States of America Impact: By incorporating a spatial low-rank imaging method, MCDW-pCASL enables accelerated, high-resolution quantification of perfusion and BBB water exchange with good repeatability. Future clinical applications of MCDW-pCASL for assessing perfusion and BBB function are warranted.
		461-05-012. Picture to video: A Novel Live MRI Technique for Assessing the Cerebrospinal Fluid Flow Changing of Cervical Disc Herniation. Jiahao Gao, Shiman Wu, yue gao, zhe feng, Minghao Shao, Zhiwei Qin, Shaofeng Duan, Wei Zhu, Zhenwei Yao, Jiawen Zhang, Ren Yan Huashan Hospital, Fudan University, China Impact: The novel Live MRI enables the dynamic observation of cerebrospinal fluid (CSF) circulation obstruction caused by herniated discs and its postoperative improvement, providing a novel reference for evaluating surgical efficacy, thereby exploring how herniated discs affect CSF circulation.
		461-05-013. Time-STAMP MRI as a Functional Probe of CSF Dynamics: Towards Task-Based Evaluation of Chiari and ETV Patients Clio Gonzalez Zacarias, Isabella Friedli, Lucas Conner, Isabel Torres, Matthew Borzage, Anand Joshi, Theodore Calleja, Marquis Chapman, Noel Arugay, Madison Gutierrez, Eamon Doyle, Jason Hauptman, Andrew Roman, Kevin King, Diane Aum, Mark Krieger, John Wood, J. Gordon McComb, Stefan Blüml, Peter Chiarelli Children's Hospital Los Angeles, Los Angeles, United States of America Impact: Our results demonstrate that controlled pressure challenges can reveal subtle CSF flow adaptations, supporting the future use of task-based MRI paradigms to non-invasively assess CSF obstruction and potentially better assess surgical candidacy in patients with Chiari malformation and aqueductal obstruction.
		461-05-014. Physics-informed synthesis of contrast agent-free DSC parameters and novel MR biomarkers Lu Wang, Zhen Xing, Congbo Cai, Dairong Cao, QING LI, Shuhui Cai Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, China Impact: This approach enables contrast-agent-free assessment of brain tumors by simultaneously providing standard perfusion parameters and novel microstructural biomarkers. It promises to enhance diagnostic accuracy and enable safer, more frequent monitoring of tumor progression.
		461-05-015. Early Functional Disruption of Brain Clearance in Sleep Disorders Detected by glymphatic multimodal MRI Jun-Hee Kim, Hyochul Lee, Roh-Eul Yoo, Seung Hong Choi Seoul National University, Seoul, Korea, Republic of Impact: This study identifies early functional decline of brain-clearance in insomnia symptoms using IR-ALADDIN and fMRI-based CSFpulse. The findings suggest that meningeal and CSF pulsatility imaging could provide sensitive biomarkers for detecting early sleep-related impairment in brain clearance before structural alteration.