Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition • 09-14 May 2026

Digital Poster

When Brain Clearance Fails: Glymphatic Dysfunction Across Disorders

Back to the Program-at-a-Glance

When Brain Clearance Fails: Glymphatic Dysfunction Across Disorders
Digital Poster
Neuro B
Tuesday, 12 May 2026
Digital Posters Row A
16:00 - 16:55
Session Number: 460-05
No CME/CE Credit
Similar Sessions
This session will explore glymphatic dysfunction in a range of neurological and neuro-oncologic disorders, including Parkinson’s disease, Alzheimer’s disease, epilepsy, insomnia, and gliomas. Emphasis will be placed on the role of the glymphatic system in brain waste clearance, how its impairment contributes to disease pathophysiology, and emerging imaging techniques for assessing glymphatic function in vivo. Speakers will discuss the mechanistic links between disrupted glymphatic clearance, neurodegeneration, sleep disturbances, seizure activity, and tumor biology, highlighting common and disease-specific patterns.
  Figure 460-05-001.  MRI-Based Perivascular Space Network Disturbance and Enhanced Coupling in Parkinson’s Disease
Yang Zhao, Yufan Chen, Tao Gong, Xiuzheng Yue, guangbin wang
Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, China
Impact: A multi-modal MRI framework enables multi-node detection of the perivascular space network in Parkinson’s disease, revealing network-level disturbance and abnormally strengthened coupling across fluid compartments that predict cognitive decline and offer a quantitative biomarker for individualized cognitive assessment.
  Figure 460-05-002.  Glymphatic Dysfunction Measured by an Age-Corrected ΔALPS Index is Linked to Motor Symptoms in Early Parkinson's Disease
Yuan Tian, Xiaopeng Qu, jianxiu lian, Pengfei Liu
First Affiliated Hospital of Harbin Medcial University, China
Impact: By introducing an age-corrected ΔALPS index, this study disentangles Parkinson's disease-specific glymphatic impairment from normal aging, reveals its specific link to motor severity, and establishes its potential as an early PD biomarker.
  Figure 460-05-003.  Diffusion-Cognitive Correlates of Cholinergic Pathways Denervation and Glympathic System Activity in Alzheimer Disease
Pohchoo Seow, Septian Hartono, Weiling Lee, Chuen Chai Seow, Kang Seng Ting, Wei Shan Li, Kok Pin Ng, Pik Hsien Chai, Bertwin Chen, Shi Ni Phua, Yee Wei Koh, Yao Chia Shih, Ling Ling Chan
Singapore General Hospital, Singapore, Singapore
Impact: Our study establishes diffusion imaging correlates as objective biomarkers for cognitive manifestation by interrogating the relations between cholinergic-NBM (nucleus basalis of Meynert) denervation and glymphatic-related activity, potentially stratifying AD subgroups at risk for personalized management.
  Figure 460-05-004.  Vascular risk and enlargement of lateral ventricles are associated with DTI-ALPS in Alzheimer's disease
Isam Adnan, Samantha Keil, Xiuyuan Wang, Tsung-wei Hu, Tracy Butler, Lidia Glodzik, Gloria Chiang, Yi Li, Liangdong Zhou
Brain Health Imaging Institute, New york, United States of America
Impact: Multimodal neuroimaging analysis reveals that vascular risks including health of deep medullary vein, burden of white matter hyperintensities, as well as the enlargement of lateral ventricles are associated with DTI-ALPS, suggesting DTI-ALPS to be a vascular and atrophy associated biomarker.
  Figure 460-05-005.  Multimodal MRI Evaluation of Glymphatic System Function in Patients with Temporal Lobe Epilepsy
Zhuo Wang, Guangxu Han, Jinqin Li, Dengyan Song, Hao Ye, Yuanyuan wei, Bing Chen
The First Clinical Medical College of Ningxia Medical University, Yinchuan, China
Impact: This study’s findings further emphasize the close connection between dysfunctions of the brain's glymphatic system and abnormalities in cerebrospinal fluid dynamics. These discoveries provide important imaging evidence for further investigation into the metabolic clearance mechanisms of TLE and its heterogeneity.
  Figure 460-05-006.  Glymphatic Impairment: a potential early mechanism in glioma-related epilepsy
Ting Chen, Xiaoyue Ma, MENGZHU WANG, Li Kaixin, Yong Zhang
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Impact: The complexity pathogenesis of glioma‐related epilepsy (GRE) remains incompletely understood, necessitating further investigation into its underlying pathophysiology .
  Figure 460-05-007.  Distinct Glymphatic Dysfunction Patterns in Glioma and Brain Metastasis Revealed by Diffusion Tensor Imaging–Based ALPS Index
Jin wang, yuxia liang, Yu Shang, Qinqin Xie, Zirui Zhao, Ming Zhang, chen niu
The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
Impact: This study reveals tumor-type–specific patterns of glymphatic dysfunction and supports DTI-ALPS index as a novel imaging marker for assessing perivascular clearance failure in neuro-oncology.
  Figure 460-05-008.  Limited dependence of brain arterial pulsation strength on vascular tone
Jacco de Zwart, peter van Gelderen, Jeff Duyn
National Institutes of Health, Bethesda, United States of America
Impact: Simultaneous measurement of cardiac-cycle induced CSF pulsation strength and BOLD fMRI global signal indicates that pulsation strength is minimally affected by vascular tone. This suggests that previously observed NREM-sleep dependent tissue waste clearance is not explained by increased pulsation strength.
  Figure 460-05-009.  DTI-ALPS revealed glymphatic system dysfunction in patients with insomnia
Ruifang Xiong, Jiankun Dai, Ye Wang, Qingqing Wen, Xiaoping Tang
The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
Impact: The DTI-ALPS index may serve as a potential imaging biomarker for glymphatic dysfunction in insomnia, aiding in the early identification of patients at risk for cognitive decline.
  Figure 460-05-010.  Quantitative evaluation of dynamic glymphatic activity in insomnia: A contrast-enhanced synthetic MRI study
Ruifang Xiong, Jiankun Dai, Ye Wang, Qingqing Wen, Xiaoping Tang
The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
Impact: Dynamic contrast-enhanced syMRI enabled quantitative assessment of glymphatic dysfunction in insomnia, providing novel insights into its pathophysiology and potentially facilitating early diagnosis and treatment monitoring of sleep-related neurological disorders.
  Figure 460-05-011.  How sleep disorder affect glymphatic circulation and network efficiency in internet gaming disorder: Insights from a DTI-ALPS
Longyao Ma, Bohui Mei, Mengzhe Zhang, Wenjing Li, Xinyu Wang, Shaoqiang Han, Yong Zhang
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Impact: This study confirms that sleep disorders exacerbate glymphatic system dysfunction and impair human brain networks in IGD patients.
  Figure 460-05-012.  7T MRI reveals altered glymphatic function in Cushing’s Disease: a study of enlarged perivascular space
Yuan Li, Yanglei Wu, Zeyu Liu, Xinying Huang, Feng Feng
MR Research Collaboration, Siemens Healthineers Ltd., Beijing, China
Impact: Using 7T MRI, this study found Cushing's disease patients had a significantly increased number of enlarged perivascular space- (ePVS), suggesting glymphatic system impairment. This non-invasive imaging biomarker may link glymphatic clearance to the neuropsychiatric symptoms of the disease.
  Figure 460-05-013.  Assessing the Influence of White Matter Microstructure on the Analysis Along the Perivascular Space (ALPS) Index
Van Vo Quoc, Chih Chien Tsai, Jiun Jie Wang
Chang Gung University, Taoyuan, Taiwan
Impact: Fixel-based ALPS analysis enhances understanding of glymphatic diffusion by disentangling white matter structural effects, providing a more specific neuroimaging marker for detecting glymphatic dysfunction and cognitive decline in neurodegenerative diseases.
  Figure 460-05-014.  State-dependent alterations of glymphatic function in primary dysmenorrhea: an exploratory, hypothesis-generating study
Xue Chen, Xiaowei Wu, Mengying Zhu, Yujin WU, Peng Wu, Ying Fei, Zhou Huang, Yonggang Li
Suzhou Municipal Hospital, Suzhou, China
Impact: This study identifies menstrual-phase–specific hyperactivation of white matter glymphatic function in primary dysmenorrhea (PDM), revealing state-dependent neurofluid regulation linked to age at menarche and emotional factors. These findings suggest potential imaging biomarkers and mechanistic targets for PDM.
  Figure 460-05-015.  Glymphatic Dysfunction in Type 2 Diabetes: Insights from DTI-ALPS
Yujuan Wang, Yang Ji, Guangxu Han, Shuanghong Zhang
The First Affiliated Hospital of Xi'an Medical University, Xian, China
Impact: Our findings suggest that DTI-ALPS may help clinicians and researchers better understand glymphatic dysfunction in T2DM, supporting early identification of cognitive risk and informing strategies for monitoring brain health in diabetic populations

Back to the Program-at-a-Glance

© 2026 International Society for Magnetic Resonance in Medicine