This session will explore glymphatic dysfunction in a range of neurological and neuro-oncologic disorders, including Parkinson’s disease, Alzheimer’s disease, epilepsy, insomnia, and gliomas. Emphasis will be placed on the role of the glymphatic system in brain waste clearance, how its impairment contributes to disease pathophysiology, and emerging imaging techniques for assessing glymphatic function in vivo. Speakers will discuss the mechanistic links between disrupted glymphatic clearance, neurodegeneration, sleep disturbances, seizure activity, and tumor biology, highlighting common and disease-specific patterns.