Neuro-Biomarkers
Digital Poster
Preclinical
Thursday, 14 May 2026
From molecules to imaging: Mapping Biomarkers through various Magnetic Resonance Techniques
|
666-03-001.
Quantitative UTE MRI for Demyelination Detection in Alzheimer's Disease Using a Transgenic Mouse Model
Impact: The
STAIR‑UTE sequence allows for quantitative myelin imaging at 3T MRI, enabling
sensitive detection of demyelination in the mouse brain. This advanced
technique shows strong potential for in vivo evaluation and monitoring of
myelin integrity in Alzheimer’s disease models.
|
||
|
666-03-002.
Multimodal imaging reveals sex-specific metabolic rewiring in the hAPP-J20 model of Alzheimer's disease
Impact: Hyperpolarized ¹³C MRI detects early glycolytic alterations in the hAPP-J20 Alzheimer’s model before changes in glucose uptake or mitochondrial metabolism appear. Integrating HP-MRI, FDG-PET, and metabolomics reveals distinct, sex-dependent trajectories of brain energy dysregulation across disease progression.
|
||
|
666-03-003.
Neurometabolic and Behavioural Alterations in 6-OHDA Parkinson’s Disease Model using MRS and Functional Assessments
Impact: Early
behavioral, cognitive and differential neurobiochemical changes (in the
prefrontal cortex and striatum) were observed in the 6-OHDA-induced PD model, suggesting
oxidative stress, energy dysregulation, and neuronal degeneration associated
with motor dysfunction.
|
||
|
666-03-004.
Investigating the Impact of Aquaporin-4 Facilitation on Glymphatic Transport After Chronic Hypoperfusion in Rats
Impact: Chronic cerebral hypoperfusion may impair the glymphatic pathway and that the AQP4 facilitator TGN-073 could enhance glymphatic flow. Consequently, AQP4 facilitators may represent a promising therapeutic target in mitigating the adverse effects of cerebral hypoperfusion, including waste accumulation and neurodegeneration.
|
||
|
666-03-005.
Cellular processes and volume loss in the corpus callosum of mice following juvenile mild traumatic brain injury
Impact: We provide evidence for white matter remodelling following injury
in a mouse model of pediatric concussion, setting the stage for future studies
probing the causal role of oligodendrogenesis and microglia in post-injury
impairment and recovery.
|
||
|
666-03-006.
Peripheral serum metabolomic alterations in Schizophrenia: a preliminary NMR-based metabolomics study
Impact: This ¹H-NMR
metabolomics study, stratified by treatment response, reveals TRS and
NTRS-linked peripheral metabolic alterations in schizophrenia. The findings
suggest group-specific disturbances in bioenergetics, amino-acid metabolism & membrane turnover, supporting serum NMR metabolomics as a promising
biomarker approach in schizophrenia research.
|
||
|
666-03-007.
Enhanced neurometabolic activity in Leprdb/db Mouse Model of Type 2 Diabetes: A ¹H-[¹³C]-NMR Study
Impact: Our findings indicate that type-2 diabetes differentially affects
excitatory and inhibitory neuronal activity in the brain, providing a
foundation for interventional strategies to manage brain health under diabetic
conditions.
|
||
|
666-03-008.
Whole-brain multiparametric MRI reveals cerebellar microstructural alterations in Atad5 knockout mice
Impact: A novel genetic defect model
affecting DNA replication (Atad5 heterozygous knockout mice) revealed
microstructural alterations in the cerebellum—including atrophy, cell loss, and
loss of neuronal connectivity—which were quantitatively assessed using diffusion-
and relaxation-based MRI techniques.
|
||
|
666-03-009.
Non-invasive Detection of Region-Specific Glutamatergic Alterations in Alcohol-Exposed Mice Using 7 T GluCEST MRI
Impact: GluCEST MRI at 7 T noninvasively detects region-specific glutamate alterations caused by alcohol exposure, revealing selective effects in reward-related regions like the nucleus accumbens and providing a powerful platform to study alcohol’s impact on brain neurochemistry.
|
||
|
666-03-010.
Striatal Microstructural Alterations Revealed by NEXI in a Mouse Model of Glucose Transporter-1 Deficiency Syndrome
Impact: Neurite EXchange Imaging (NEXI) characterizes
microstructural alterations associated with glucose deficiency, identifying the
striatum as a primary site of vulnerability to chronic cerebral energy
deprivation and providing potential noninvasive biomarkers for pathology monitoring.
|
||
|
666-03-011.
Multimodal non-invasive interrogation of chemo-brain using hyperpolarized magnetic resonance and optical imaging
Impact: This study introduces a sensitive, multimodal imaging
approach that detects potential metabolic and neuronal transport
alterations in a chemotherapy-induced cognitive impairment mouse model. Combining HP-MR and
optical imaging may enable improved diagnosis and
therapeutic evaluation of neurotoxicity in cancer patients.
|
||
|
666-03-012.
DCE-MRI gadolinium leakage assessment in a novel mouse model of ultrasound-microbubble mediated blood-brain barrier opening.
Impact: In vivo DCE-MRI detection of gadolinium leakage enabled quantitative assessment of ultrasound-microbubble-mediated blood-brain barrier opening in mice, facilitating future exploration of barrier dysfunction and its contribution to neurodegenerative disease development.
|
||
|
666-03-013.
Age-Related Volumetric Brain Alterations from Early Adulthood to Mid-Life in Female Wistar Rats
Impact: This longitudinal study highlights mid-life brain changes in rats, providing a reference point for future aging research and highlighting the value of animal MRI for tracking age-related changes across brain systems.
|
||
|
666-03-014.
Sex-specific structural and metabolic changes in the mouse brain induced by ketogenic diet
Impact: A 4‑week ketogenic diet alters hippocampal metabolism (↑glutamine, ↓taurine, ↓choline) without structural changes, highlighting early neuron–glia adaptations. This may inform future studies on how short-term dietary interventions affect brain function and resilience in preclinical and clinical contexts.
|
||
|
666-03-015.
Multi-Modal MRI Mouse Brain Extraction Using Template-Based Diffeomorphic Registration
Impact: Brain extraction is a crucial step in many automated neuroimaging pipelines. Preclinical research, unlike in humans, continues to lack standardized pipelines. We introduce a multi-modal, template-based brain extraction pipeline for mouse models.
|
||
|
666-03-016.
Quantitative MRI of Delipidation in Human Brain Samples
Impact: Controlled delipidation
revealed how lipid loss shapes MPF, MMF, T1, and T2, clarifying their
sensitivity and specificity to myelin. This improves interpretation of
quantitative MRI in demyelination and guides development of more accurate
myelin-specific imaging biomarkers.
|