Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

Hyperpolarization: Novel Methods

Digital Poster

Contrast Mechanisms

Thursday, 14 May 2026

Digital Posters Row G

08:30 - 09:25

Session Number: 666-01

No CME/CE Credit

Similar Sessions

This session focuses on technology development and applications in hyperpolarization particularly for 13C.

		666-01-001. Demonstration of the novel hyperpolarizer technique to monitor in vivo metabolism using cross and direct polarization Donghyun Hong, Dmitry Eshchenko, Meetu Wadhwa, Pinelopi Moutzouri, Paola Porcari, agnes glemot, Alia Hassan, Marco Sacher, Marc Rossire, Marc Schnell, Stefan Zollinger, Denis Lohner, Joerg Hinderer, Valentin Krebs, Benjamin Beyeler, Alec Beaton, Roberto Melzi, Kristin Granlund, Dan Vigneron, James Kempf, Renuka Sriram University Of California, San Francisco (UCSF), United States of America Impact: This work establishes cross-polarization hyperpolarization as a rapid, high-SNR method for in vivo ¹³C metabolic imaging, reducing polarization time from >60 to 10 minutes. It enables efficient, multi-organ metabolic studies and accelerates the translation of hyperpolarized MRI toward clinical applications.
		666-01-002. Comparing an iterative least squares frequency decomposition method for non-invasive 3D pH imaging against 13C MRSI in vivo Jakob Gaubatz, Florian Gaksch, Sandra Sühnel, Oscar Georgiev, Luca Nagel, Martin Grashei, Franz Schilling TUM School of Medicine and Health, TUM University Hospital, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany Impact: A new approach for 3D pH imaging using hyperpolarised ¹³C-labelled Z-OMPD was compared to conventional FID-CSI. With agreement confirmed, the method’s faster readout and greater volume coverage can now enable novel 3D insights into tumour acidification or kidney pH.
		666-01-003. Electron irradiation-induced radicals as stable endogenous agents for sodium [1-13C]pyruvate Dynamic Nuclear Polarisation Zoe Richardson, William Myers, Iain Tullis, Nichlas Vous Christensen, Duy Anh Dang, Esben Hansen, Zhuang Liu, Lotte Bonde Bertelsen, Kristoffer Petersson, Christoffer Laustsen, Damian Tyler, Jack Miller, Catriona Rooney University College London, London, United Kingdom Impact: One of the barriers to clinical scaling of hyperpolarised MRI is the need for unstable exogenous radicals. Using endogenous electron irradiation-induced radicals simplifies DNP. It removes the need for filtration and sterilisation and could allow centralised manufacturing of the radicals.
		666-01-004. Enhancing in vivo SNR of hyperpolarized pH imaging through T1 prolongation by deuteration of 13C-labelled (Z)-OMPD Florian Gaksch, Alexander Huber, Jakob Gaubatz, Sandra Sühnel, Kristin Koetz, Nadine Setzer, Silvester Bartsch, Martin Grashei, Franz Schilling TUM School of Medicine and Health, TUM University Hospital, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany Impact: T₁-prolongation by deuteration of ZOMPD substantially enhances in vivo SNR of hyperpolarized pH-imaging when avoiding co-polarization with [¹³C]urea and high injection concentrations. This allows for higher spatial resolution in hyperpolarized in vivo pH-imaging and extended perfusion times to study pH-compartments.
		666-01-005. A dedicated 13C phantom and protocol for cross-site harmonization in clinical hyperpolarized 13C MRI Kristina Jacobsen, Ingeborg Skre, Rie Olin, Mathilde Lerche Technical University of Denmark, Kgs. Lyngby, Denmark Impact: A dedicated ¹³C phantom and protocol provide a common framework for identifying and assessing inter-site variability, promoting consistent acquisition in forthcoming multi-center hyperpolarized ¹³C MRI studies.
		666-01-006. Extending the T1 lifetime of [1-13C]pyruvate to over 4 min Josh Philipp Peters, Florin Teleanu, Charbel Assaf, Huijing Zou, Jan-Bernd Hövener, Alexej Jerschow, Andrey Pravdivtsev Kiel University, Kiel, Germany Impact: More than 4 minutes T₁ enables essentially polarization loss-free transport, quality assurance and administration of hyperpolarized [1-¹³C]pyruvate for biomedical applications. Understanding and reducing relaxation sources extended the nuclear relaxation lifetimes by >600%, setting a new reference for pyruvate hyperpolarization studies.
		666-01-007. Multicenter evaluation of the POLARIS PHIP polarizer across models and imaging conditions Vencel Somai, Hadrien Dyvorne, Galen Reed, Christoph Müller, Catriona Rooney, Meret Cepero Malo, Andrei Chekushin, Senay Karaali, Zumrud Ahmodova, Martin Grashei, Jonas Handwerker, Felix Josten, Pascal P.R. Ruetten, Luca Nagel, Miriam Kirst, Sandra Sühnel, Martin Grashei, Franz Schilling, Stephen Lai, Qing Wang, Yunyun Chen, José Enriquez, James Bankson, David Gomez-Cabeza, Lluís Mangas, Gergo Matajsz, Alba Herrero Gómez, Vincent Ribas, Irene Marco-Rius, Renuka Sriram, Dan Vigneron, Jeremy Gordon, Meetu Wadhwa, Xiao Gao, Tamara Vasilkovska, Max Bullock, rafat chowdhury, Shonit Punwani, Mario Chang, Saket Patel, Roberta Pigliapocchi, Thasin Peyear, Kayvan Keshari, Ilai Schwartz, Stephan Knecht, Myriam Chaumeil NVision Imaging Technologies GmbH, Ulm, Germany Impact: POLARIS delivers fast, reliable, and reproducible [1-¹³C]pyruvate hyperpolarization, enabling standardized metabolic MRI across centers, field strengths, and models. This breakthrough accelerates translational research and multicenter studies, driving clinical adoption of real-time metabolic imaging in oncology, neurology, and cardiovascular disease.
		666-01-008. Multi Nuclei Small Animal Insert for in-vivo Hyperpolarized C13 Imaging on a Clinical MRI System Tobias Haase b. Lobmeyer, Miriam Kirst, Kristin Koetz, Sybille Reder, Martin Grashei, Franz Schilling, Volker Rasche Ulm University, Medical Center, Ulm, Germany Impact: The easy-to-use system shows adequate SNR (¹H and ¹³C) for imaging in small animals without modifying scanner hardware. Using the clinical scanners console, sequences, main magnetic field and gradient system, allow for a high degree of transferability to clinical trials.
		666-01-009. Optimization of [2-13C]Pyruvate Hyperpolarization Via the Addition of Gadolinium Zhuang Liu, Damian Tyler, Ladislav Valkovič, James Grist Oxford Centre for Clinical MR Research (OCMR), University of Oxford, Oxford, United Kingdom Impact: The liquid-state polarization level of [2-¹³C]pyruvate in the pre-clinical polarizer is possible to be nearly doubled with our optimized Gd concentration, which can significantly increase the signal-to-noise ratio (SNR) and is promising for metabolic imaging in clinical practice.
		666-01-010. Optimization of bSSFP passband periodicity for 13C metabolic MRSI at clinical field strengths Stefan Menzel, Julian Schüle, Fabian Bschorr, Tobias Speidel, Christoph Müller, Volker Rasche Ulm University, Medical Center, Ulm, Germany Impact: Optimization of passband periodicity in the bSSFP transient phase improves SNR and acquisition speed for hyperpolarized ¹³C-MRSI at clinical field strengths, enabling more efficient metabolite-separated imaging, and facilitating translation of optimized bSSFP techniques to preclinical and in-vivo metabolic studies.
		666-01-011. A Dual Multiband RF Pulse Strategy for 3D Volumetric Assessment of Saturable Hyperpolarized 13C Pyruvate Kinetics Abubakr Eldirdiri, Joshua Rogers, Dirk Mayer University of Maryland School of Medicine, Baltimore, United States of America Impact: Metabolic rates from first-order kinetic modeling in hyperpolarized ¹³C experiments are often dose-dependent, complicating comparisons across experiments. Our 3D acquisition strategy provides a metabolic metric ($V_{max}$) that is independent of substrate concentration, reducing variability in hyperpolarized ¹³C studies.
		666-01-012. Coil Combination of Hyperpolarized C-13 Imaging by Estimating L2-Optimized Sensitivity Maps Anna Bennett Haller, Minjie Zhu, Peder Larson, Jeremy Gordon, Nicholas Dwork University Of California, San Francisco (UCSF), United States of America Impact: Implementation of an L2-optimization-based sensitivity map estimator, using both substrate and product metabolite images as input, has been shown to improve SNR in HP C13 datasets.
		666-01-013. Dynamic Pyruvate-Lactate Exchange Simulation using Arbitrary Phase Encoding Schemes and Sliding-Window Reconstruction Pia Gebhard, Tobias Speidel, Fabian Bschorr, Julian Schüle, Volker Rasche Ulm University, Medical Center, Ulm, Germany Impact: A new BART-based simulation framework for dynamic 13-C metabolic imaging enables realistic pyruvate–lactate exchange studies for arbitrary phase encoding schemes. The combination of information-based undersampling and tiny golden angle refinement supports accurate, temporally resolved reconstructions using non-uniform FFT methods.
		666-01-014. Spectrally selective Seiffert Spirals for preclinical 13C metabolic MRSI at 11.7 T Julian Schüle, Fabian Bschorr, Tobias Speidel, Christoph Müller, Volker Rasche Ulm University, Medical Center, Ulm, Germany Impact: Spectrally selective Seiffert Spirals enable rapid, metabolite-specific imaging with high SNR and a lower number of readouts compared to other acquisition techniques, possibly enabling single-shot trajectories to be combined with high-field hyperpolarized ¹³C studies.
		666-01-015. Kinetic-Anchored IDEAL CSI for HP 13C Pyruvate: Center-k Estimation and Voxel-wise Metabolite Imaging Ching-Yi Hsieh, Ying-Chieh Lai, Kuan-Ying Lu, Gigin Lin Chang Gung University, Taoyuan, Taiwan Impact: This work establishes a kinetics-anchored IDEAL-CSI framework enabling accurate voxel-wise metabolic mapping in hyperpolarized $^{13}$C MRI, improving quantification of pyruvate–lactate dynamics and supporting robust, clinically adaptable assessment of metabolic alterations in irradiated and control cell models.