Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

Novel Approaches to Spectroscopy

Power Pitch

Contrast Mechanisms

Wednesday, 13 May 2026

Power Pitch Theatre 2

08:20 - 09:56

Moderators: Diana G. Rotaru & Dunja Simicic

Session Number: 552-01

No CME/CE Credit

Similar Sessions

This power pitch covers a wide range of spectroscopy techniques including proton and non-proton applications.

Skill Level: Intermediate

08:20		552-01-001. BasisREMY: From MRS Data to Study-Specific Basis Sets via Automated Metadata Extraction and Guided Simulation Julian Merkofer, Alessio Siviglia, Andrew Wright, Antonia Kaiser, Dunja Simicic, Festus Slade, Gizeaddis Simegn, Jessica Archibald, Jillian Eichstaedt, Kay Igwe, Kelley Swanberg, Mahrshi Jani, Zahra Shams, Saipavitra Murali-Manohar Eindhoven University of Technology, Eindhoven, Netherlands Impact: BasisREMY automates MRS basis set simulation, simplifying a complex, expert-dependent process. It guides non-experts in parameter selection and streamlines spectral fitting workflows. This will enable reliable metabolite quantification while improving accessibility, reproducibility, and efficiency in MRS research and clinical applications.
08:22		552-01-002. Impact of low-rank denoising on cerebral metabolic flux estimates from dynamic deuterium MRSI at 7T Anna Duguid, Wolfgang Bogner, Fabian Niess, Lukas Hingerl, Viola Bader, Sabina Frese, Aaron Osburg, Hauke Fischer, Martin Krssak, Ivan Petrović, Alessio Siviglia, Brayan Alves, Cristina Cudalbu, Bernard Lanz, Bernhard Strasser Medical University of Vienna, Vienna, Austria Impact: Dynamic deuterium-MRSI enables mapping of cerebral metabolic fluxes but suffers from low SNR. Monte Carlo simulations showed that two low-rank denoising strategies reduced the error and variance of fluxes, supporting more reliable flux mapping for studying, e.g., pathology-driven metabolic alterations.
08:24		552-01-003. Optimizing MRS tissue correction sensitized to aging-related neurometabolic differences in GABA+ and Glx Lisa Krishnamurthy, Venkatagiri Krishnamurthy Emory University School of Medicine, Atlanta, United States of America Impact: Refining MRS tissue correction methods to account for aging-related neurometabolic (not just structural) differences is critical for precise EIB estimation, which thereby improves clinical interpretation of aging-related neurometabolic differences.
08:26		552-01-004. In Vivo Characterization of the Redox Balance in IDH-Wildtype Glioblastomas using J-difference Edited MEGA-sLASER MRS at 3T Seyma Alcicek, Andrei Manzhurtsev, Dennis Thomas, Iris Divé, Katharina Weber, Vincent Prinz, Daniel Jussen, Dinesh Deelchand, Georg Oeltzschner, Michael Ronellenfitsch, Joachim Steinbach, Elke Hattingen, Ulrich Pilatus, Katharina Wenger Goethe University, University Hospital Frankfurt, Institute of Neuroradiology and Cooperative Brain Imaging Center - CoBIC, Frankfurt am Main, Germany Impact: This study establishes clinical feasibility of noninvasive redox metabolite assessment in glioblastoma using MEGA-sLASER MRS at 3T. The findings identify glutathione and cystathionine as promising biomarkers of oxidative stress and treatment response, enabling individualized strategies for redox-modulating therapies in glioblastoma.
08:28		552-01-005. Towards Dynamic MRSI at 10.5 Tesla: Analysis of Intra-Session Stability for Neurochemical Imaging Lukas Hingerl, Bernhard Strasser, Simon Schmidt, Korbinian Eckstein, Edward Auerbach, Andrew Wright, Fabian Niess, Pascal Baltzer, Wolfgang Bogner, Malgorzata Marjanska Medical University of Vienna, Vienna, Austria Impact: Our results demonstrate that dynamic FID-MRSI at 10.5T for the investigation of neurochemical pathways with an optimized Concentric-Ring-Trajectory-MRSI sequence for increased temporal stability is possible. This paves the way for functional studies or the characterization of metabolism via substrate administration.
08:30		552-01-006. Myocardial Energetics in Hypertrophic Cardiomyopathy: ³¹P-MRS Reveals Phenotypic Insights and Mechanical Performance Yifan Dong, Wenjing Yang, jianxiu lian, Dandan Zheng, Minjie Lu Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Impact: Our study integrates ³¹P-MRS–based energetic quantification with myocardial strain analysis to link metabolic impairment to functional performance in hypertrophic cardiomyopathy (HCM). It also reveals a more severe energetic impairment for obstructive HCM, holding promise for refining disease management.
08:32		552-01-007. Anterior Cingulate Creatine and Glutamate-GABA Balance in Relation to Anxiety and Obsessive and Compulsive Tendencies Wei Su, Qianwen Zhang, Xuan Li, LingYang Zeng, Zhengqi Zhu, Jiaxiang xin, Kaihua Zhang Shandong Normal University, Jinan, China Impact: This study highlights the neurobiochemical basis of anxiety-related obsessive–compulsive tendencies and provides a non-clinical framework for exploring how brain metabolites.
08:34		552-01-008. Longitudinal metabolic and microstructural changes in low-grade gliomas treated with vorasidenib Capucine Cadin, Lucia Nichelli, Malgorzata Marjanska, Mélanie Didier, Filip Szczepankiewicz, Markus Nilsson, Alberto Picca, Caroline Dehais, Bertrand Mathon, Stéphane Lehéricy, Franck Bielle, Marc Sanson, Mehdi Touat, Francesca Branzoli Paris Brain Institute - ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne University, Paris, France Impact: Complementary MRS and diffusion MRI biomarkers could non-invasively track early metabolic and microstructural changes induced by vorasidenib treatment in IDH-mutant gliomas, helping clinicians in predicting individual treatment responses and adjusting management.
08:36		552-01-009. Linear-combination modeling of long echo-time MRSI with maximum-echo readout for SNR-efficient metabolic imaging Helge Zöllner, Dunja Simicic, Georg Oeltzschner, Peter Barker Johns Hopkins University School of Medicine, Baltimore, United States of America Impact: Simultaneous linear-combination modeling of long-TE MRSI data with maximum-echo readout improves SNR-efficiency and metabolic image quality without increasing the scan time. The SNR-boost allows for long-TE metabolic imaging with 5 mm in-plane resolution in a clinically relevant timeframe.
08:38		552-01-010. Comparison of Deuterium Metabolic Imaging-based Methods for Assessment of the Hepatocellular Lipid Content Lorenz Pfleger, Viola Bader, Fabian Niess, Anna Tosin, Clemens Baumgartner, Peter Wolf, Anna Duguid, Bernhard Strasser, Thomas Scherer, Wolfgang Bogner, Martin Krssak Medical University of Vienna, Vienna, Austria Impact: The assessment of deuterium hepatocellular lipid content (²H-HCL) using deuterium metabolic imaging (DMI) is feasible and is a first step for setting up dynamic studies with administration of ²H-labeled substances to trace the hepatic lipid metabolism.
08:40		552-01-011. Frequency and Phase Correction of 2-Hydroxyglutarate-Edited MRS Data Christopher Wu, Anke Henning, Jia Guo, Kimberly Chan Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, United States of America Impact: Frequency and phase misalignment in 2HG-edited MRS data commonly arises during acquisition and complicates the interpretation of the data if not corrected. Existing correction methods demonstrate limited efficacy. This study introduces a new correction method tailored for 2HG-edited data.
08:42		552-01-012. Age-related Changes in Neurometabolite Levels during Early Infancy: Using HBCD MRS Data Release 1.0 Saipavitra Murali-Manohar, Helge Zöllner, Christopher Davies-Jenkins, Aaron Gudmundson, Steve Hui, Yulu Song, Gizeaddis Simegn, Zahra Shams, Abdelrahman Gad, Borjan Gagoski, M. Dylan Tisdall, Muhammad Saleh, Ralph Noeske, William Clarke, Timothy Hendrickson, Erik Lee, Heather Volk, Georg Oeltzschner, Jessica Wisnowski, Richard AE Edden Johns Hopkins University School of Medicine, Baltimore, United States of America Impact: This study unveils the developmental trajectory of neurometabolite levels, including the neurotransmitters glutamate and $\gamma$-aminobutyric acid (GABA) and the antioxidant glutathione (GSH), from 0–2 months of age based on a cross-sectional analysis of the first HBCD data release.
08:44		552-01-013. First demonstration of Human brain diffusion-weighted MRS at 11.7T Eloise Mougel, Franck Mauconduit, Caroline LeSter, Son Chu, Shajan Gunamony, Alfredo Lopez Kolkovsky, Nicolas Boulant, Julien Valette Université Paris-Saclay, Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Molecular Imaging Research Center (MIRCen), Fontenay aux Roses, France Impact: dMRS acquisition in vivo on an 11.7T clinical scanner offers high SNR in reasonable acquisition time. ADC for long diffusion times of several metabolites, such as, NAA, Ins, Glu, can be measured, opening a new way for exploring human microstructure.
08:46		552-01-014. High-Sensitivity 7T ³¹P Metabolic Mapping using A Conformal Birdcage ¹H/31P Coil Cheng Lai, Hanlin Yue, Jingtao Cao, Zipan Ran, Huabin Zhu, Zhentao Zuo Chinese Academy of Sciences, Beijing, China Impact: This conformal birdcage ¹H/31P Coil provides excellent decoupling, yielding high-resolution ³¹P maps. The integrated ¹H array enables robust, physiologically-consistent quantitative VOI analysis.
08:48		552-01-015. Feasibility of high-resolution Cardiac Deuterium Metabolic Imaging using a 2H-CRT-MRSI sequence at 7T Sabina Frese, Stefan Wampl, Lukas Hingerl, Bernhard Strasser, Viola Bader, Anna Duguid, Aaron Osburg, Martin Krssak, Thomas Scherer, Albrecht Schmid, Pascal Baltzer, Wolfgang Bogner, Fabian Niess Medical University of Vienna, Vienna, Austria Impact: High-resolution Deuterium Metabolic Imaging (DMI) at 7T enables non-invasive mapping of cardiac glucose metabolism, addressing a clinical need in providing complementary information to conventional ¹H-MRI via metabolic insight into cardiac pathophysiology and paving the way for clinical translation.
08:50		552-01-016. In vivo 2H-MRI Detection of AAV-Mediated Liver Gene Delivery Using the Human Thymidine Kinase-1 Reporter Gene Hyla Allouche-Arnon, Oded Singer, Elton Montrazi, Talia Harris, Amnon Bar-Shir Weizmann Institute of Science, Rehovot, Israel Impact: Upon successful implementation, this humanized immunocompatible ²H-MRI reporter system will profoundly impact the field by enabling safe, quantitative, and longitudinal monitoring of gene delivery efficiency, advancing non-radioactive molecular imaging, and accelerating the clinical translation of gene and cell therapies.
08:52		552-01-017. Characterization of Brain Tumors Using 23Na MRI with Inversion Recovery at 7T Sisi Li, Jianxun Qu, Letian Yuan, Chaofei He, Xiaoxiao Ma, Caohui Duan, Xin Lou MR Research Collaboration, Siemens Healthineers Ltd., Beijing, China Impact: This study demonstrates the potential of high-resolution ²³Na-MRI with inversion recovery at 7T for noninvasive distinction of WHO I-III and IV tumors by exploiting T1-relaxation differences of intra-/extra-cellular compartments. The improved pathological specificity holds promise for early detection and monitoring.
08:54		552-01-018. Principal component analysis (PCA) applied to ³¹P MR spectra from independent exams reveals reproducible metabolic signatures Fernando Arias-Mendoza, Pradeep Kumar Gupta, David Nelson, David Tischfield, Kavindra Nath, Mariusz Wasik, Ravi Srinivasan Advanced Imaging Research, Inc., Cleveland, United States of America Impact: Principal component analysis of ³¹P MR spectra from preclinical melanoma and clinical lymphoma exams revealed reproducible metabolic biomarkers that correlate, and therefore predict therapy response. This operator-free framework supports translational application of ³¹P MRS in precision oncology.