Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition • 09-14 May 2026

Digital Poster

Hyperpolarized Gases

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Hyperpolarized Gases
Digital Poster
Contrast Mechanisms
Monday, 11 May 2026
Digital Posters Row J
16:10 - 17:05
Session Number: 369-05
No CME/CE Credit
Similar Sessions
This session focuses on the acquisition and applications of hyperpolarized 129Xe gas.
  Figure 369-05-001.  Spatially Resolved Measurements Mapping 129Xe T2-Star in Pulmonary Membrane Tissue and Red Blood Cells
Anna Costelle, Suphachart Leewiwatwong, John Mugler, Seth Lee, David Mummy, Bastiaan Driehuys
Duke University, Durham, United States of America
Impact: By spatially mapping the $T_2^*$ of 129Xe in membrane tissue and RBCs, we measure the mean value more precisely and enable more accurate voxel-wise correction for transverse signal decay in gas exchange MRI.
  Figure 369-05-002.  129Xe and 1H MRI lung function assessment of PAH associated with systemic sclerosis
Laura Saunders, Guilhem Collier, Paul Hughes, Scarlett Strickland, Muad Almsaaid, Rebecca Burney, Ian Smith, Laurie Smith, Graham Norquay, Jemima Pilgrim-Morris, Helen Marshall, Alberto Biancardi, Mack Caraher, Shruti Kulkarni, Felicity Hitchcock, Neil Stewart, Andy Swift, Alexander Rothman, David Kiely, Robin Condliffe, Jim Wild, Roger Thompson
The University of Sheffield, Sheffield, United Kingdom
Impact: 129Xe-MRI gas transfer (RBC:M) is impaired in patients with systemic sclerosis (SSc) and pulmonary arterial hypertension (PAH), and correlates significantly with invasive markers of disease severity suggesting its potential as a non-invasive marker of PAH in patients with SSc.
  Figure 369-05-003.  Hybrid CNN-Transformer Architectures Enable Superior Acceleration in Hyperpolarized ¹²⁹Xe MRI Reconstruction
Ramtin Babaeipour, Alexei Ouriadov, Matthew Fox
Western University, London, Canada
Impact: KTMR enables clinically transformative 10-fold acceleration with minimal quality degradation, reducing breath-hold requirements from 15–20 seconds to 2–3 seconds. This dramatically expands hyperpolarized ¹²⁹Xe MRI accessibility for patients with respiratory compromise while establishing the first benchmark for transformer-based reconstruction approaches.
  Figure 369-05-004.  Open-Source Deep Learning Denoising and Gibbs Artifact Removal Improves SNR in Hyperpolarized ¹²⁹Xe Ventilation MRI
Rajagopalan Sundaresan, Alberto Biancardi, Guilhem Collier, Neil Stewart, Yves Brown, SUDHANYA Chatterjee, Ramesh Venkatesan, Jim Wild
The University of Sheffield, Sheffield, United Kingdom
Impact: This framework enables SNR improvement in ¹²⁹Xe ventilation imaging across field strengths. By demonstrating effective training using natural images, this approach increases accessibility by enabling cost-effective natural-abundance xenon imaging and opens pathways for cross-platform application in multi-centre clinical trials.
  Figure 369-05-005.  Conditional Diffusion Model for Hyperpolarized 129Xe MR Image Generation Based on Mask-Guided Cross-Attention
Muhong Li, Sa Xiao, Linxuan Han, Xin Zhou
State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China
Impact: We propose an augmentation method for 129Xe MRI data that combines lung mask with a cross-attention block, addressing the challenge of data scarcity caused by the difficulty in acquiring images due to the unique imaging approach of 129Xe MRI.
  Figure 369-05-006.  First In-Vivo Hyperpolarized Xenon-129 Imaging Utilizing an Asymmetrical Birdcage Coil
Wolfgang Loew, Matthew Willmering, Laura Walkup, Jason Woods, Charles Dumoulin
Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
Impact: An asymmetrical birdcage coil improves xenon-129 excitation uniformity across the thorax. By eliminating the need for size-specific transmit coils the design supports broader clinical adoption and multi-site standardization of functional lung imaging while also enabling phased array coil integration.
  Figure 369-05-007.  Improving the precision of hyperpolarized 129Xe MR spectroscopy using heart rate-based spectral averaging
Seth Lee, Anna Costelle, Suphachart Leewiwatwong, David Mummy, Bastiaan Driehuys
Duke University, Durham, United States of America
Impact: The variability of the RBC:M measurement caused by cardiogenic signal oscillations is minimized by averaging spectra over whole cardiac cycles. As a reasonable alternative, similar repeatability can be achieved by averaging for 1 second.
  Figure 369-05-008.  Resorcinarene trimer amine (R3A) – a hyperpolarized xenon-129 dual-contrast molecular imaging agent
Yurii Shepelytskyi, Viktoriia Batarchuk, Mackenzie Dillon, Rubiya Mohammed, Guillem Dayer, Carson Hasselbrink, Mitchell Albert
Lakehead University, Thunder Bay, Canada
Impact: The novel resorcinarene trimer amine is a unique source of strong dual T2* and HyperCEST contrast suitable for high-sensitivity molecular MRI imaging at clinically relevant 3.0T field strength.
  Figure 369-05-009.  Water Stable Multivariate Metal-Organic Framework for Enhanced Hyperpolarized Xenon MRI in Living Cells
Zhen Wang, Qingbin Zeng, Qianni Guo, Xinxin Yang, Xin Zhou
Innovation Academy for Precision Measurement Science and Technology,CAS, Wuhan, China
Impact: We developed an innovative multivariate strategy that enhances the Hyper-CEST MRI signal of Xe molecular cages by fine-tuning the Xe-host interaction. This method enabled successful Xe imaging in living cells and presents a generalizable approach for designing advanced Xe biosensors.
  Figure 369-05-010.  Exploring the Feasibility of Dissolved-Phase Hyperpolarized 129Xe MR at 0.5 T with Chemical Exchange MR
Benjamin LB Wilson, Graham Norquay, Jan Wolber, Jim Wild
The University of Sheffield, Sheffield, United Kingdom
Impact: These simulations indicate that dissolved-phase 129Xe MR spectroscopy in the lungs and other tissues will be feasible at the lower magnetic field strength of 0.5 T and form a basis for pulse sequence optimization for low-field 129Xe spectroscopic imaging.
  Figure 369-05-011.  Hyperpolarized 129Xe MRSI and RBC Oscillation Analysis for Assessing Pulmonary Embolism and Hyperoxic Vascular Response
Michael Væggemose, Sebastian Kridal, Mattias Kristensen, Maya Sanjuan, Buse Bor, Mark Ellegaard, Rolf Schulte, Esben Hansen, Mads Lyhne, Christoffer Laustsen
Aarhus University, Aarhus, Denmark
Impact: This study demonstrates that combining dissolved-phase ¹²⁹Xe imaging with RBC oscillation analysis provides complementary insights into embolic obstruction and oxygen-induced cardiopulmonary adaptation. FCM clustering highlights the complexity of regional embolism assessment in a controlled porcine model.
  Figure 369-05-012.  Deep Learning Reconstruction for 129Xe Diffusion-Weighted MRI Enables Shorter Scan Times and Use of Natural Abundant Xenon
Rajagopalan Sundaresan, Guilhem Collier, Neil Stewart, SUDHANYA Chatterjee, Ramesh Venkatesan, Jan Wolber, Jim Wild
The University of Sheffield, Sheffield, United Kingdom
Impact: Deep learning reconstruction enables faster acquisition times and use of natural-abundance xenon for 129Xe diffusion-weighted lung MRI, while maintaining quantitative accuracy. This will reduce the cost of advanced 129Xe MR lung morphometry, enable higher acceleration factors, and provide robust quantification.
  Figure 369-05-013.  Estimating 129Xe Dissolved-Phase Gas-exchange Dynamics in the Absence of Spectral Separation Using Blind Estimation
Yohn Taylor, Luis Loza, Rachel Brady, Mina Kim, Kai Ruppert, Geoff Parker
University College London, London, United Kingdom
Impact: 
Evaluating ¹²⁹Xe dissolved-phase exchange is challenging with spectral overlap. Using blind estimation and a kinetic exchange model, we quantified gas-exchange dynamics in radiation-injured and healthy rats, demonstrating strong agreement with the ground truth without requiring direct spectral separation.
  Figure 369-05-014.  Accelerating and Optimizing Stack-of-Spirals 129Xe Ventilation MRI with Ramped Flip Angles and Partial Fourier Reconstruction
Kylie Yeung, Anthony McIntyre, Fergus Gleeson, Rolf Schulte, Damian Tyler, James Grist
Oxford Centre for Clinical MR Research (OCMR), University of Oxford, Oxford, United Kingdom
Impact: The effects of sampling order, flip angle schemes and undersampling of stack-of-spirals hyperpolarized Xenon-129 ventilation imaging were investigated, first via simulations and subsequently in a healthy volunteer. Prospective undersampling shortened scan time by 30% whilst preserving image quality.
  Figure 369-05-015.  Initial Validation of 129Xe RBC oscillation phase mapping against DCE-MRI and blood flow modelling in patients with CTEPH
Jemima Pilgrim-Morris, Behdad Shaarbaf Ebrahimi, Evelyn Baldry, Laura Saunders, Paul Hughes, Scarlett Strickland, Roger Thompson, Guilhem Collier, Neil Stewart, Jim Wild
The University of Sheffield, Sheffield, United Kingdom
Impact: 129Xe RBC oscillation phase mapping showed reasonable agreement with DCE-perfusion MRI and numerical modelling in a small number of CTEPH patients. These preliminary results help validate oscillation phase mapping and demonstrate its potential sensitivity to changes in pulmonary microvascular function.
  Figure 369-05-016.  Establishing a Healthy Reference Distribution for Standardized Mapping of 129Xe Red Blood Cell Chemical Shift Heterogeneity
Anna Costelle, Suphachart Leewiwatwong, Seth Lee, David Mummy, John Mugler, Sudarshan Rajagopal, Bastiaan Driehuys
Duke University, Durham, United States of America
Impact: This study establishes a healthy reference distribution and corresponding thresholds for 129Xe RBC chemical shift mapping with CSI, permitting more rigorous and precise quantification of the heterogeneity observed in pulmonary hypertension.

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